Abstract: The invention provides a method of printing, onto a substrate (12), an array (14) of spots of reagent compositions for use in a chemical and/or biochemical analysis. The method includes displacing an array of reagent composition containing capillary tubes (22) arranged alongside one another from an inoperative position to an operative position in which open ends of the capillary tubes (22) simultaneously impinge against a substrate and thereafter displacing the array of tubes (22) from the operative position back to the inoperative position. The invention extends to a printing apparatus (10), a method of printing a layered array of spots of reagent compositions, a method of introducing reagent compositions into the tubes, a reagent introducing device for introducing reagent compositions into the tubes and a printing installation which includes the printing apparatus (10) and the reagent introducing device.

Abstract: This invention relates to protein and/or polypeptide production, particularly improved production of extracellular heterologous polypeptides and proteins. In particular, the invention relates to compositions of cell populations capable of improved levels of extracellular secretion relative to control populations, kits containing such compositions, methods of producing heterologous proteins of interest and recombinant microorganisms capable of improved extracellular heterologous protein production.

Abstract: The invention provides compounds of formula (I), in which R1 and R2 are independently selected from H, alkyl, aryl and heteroaryl, or R1 and R2 together form a C5-C7 ring, R3-R7 are independently selected from H, halogen, alkyl and alkoxy, X is (CH2)n in which n is 0-5, Y is selected from CH2, NR8, O or S in which R8 is H or alkyl, salts thereof and stereoisomers thereof, for the prophylaxis or treatment of malaria.

Abstract: Laser apparatus includes an output coupler, a gain medium for generating laser light, a rear optical element, and an input coupler. The input coupler is arranged to direct a pump beam to the gain medium and to define an optical path between the output coupler and the rear optical element. The rear optical element is a spatial light modulator arranged to act as an intra-cavity digital holographic mirror which can be digitally addressed. The spatial light modulator displays selectively a gray-scale image of a hologram thereby to phase-modulate laser light in the cavity, thus making it possible to generate an output laser beam having a desired characteristic. The apparatus includes a computer arranged to generate at least one hologram corresponding to a desired output beam characteristic, and a driver circuit responsive to an output from the computer to generate a corresponding gray-scale image of the hologram on the spatial light modulator.

Abstract: The invention comprises an oligonucleotide selected from the group comprising SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3; SEQ ID NO: 4; SEQ ID NO: 5 and SEQ ID NO: 6. The invention also comprises a complementary oligonucleotide of the oligonucleotide selected from the group comprising SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3; SEQ ID NO: 4; SEQ ID NO: 5 and SEQ ID NO: 6, an oligonucleotide being at least 80% homologous thereto, a truncated portion of any of the aforementioned, or a pairing of any of the aforementioned.

Abstract: The invention relates to a system for monitoring the condition of elongate structural elements and more particularly but not exclusively, to a system for monitoring and detecting cracks and breaks in railway rails. The invention furthermore extends to the methodology of designing and developing such a system. The method includes the steps of identifying modes of propagation and signal frequencies that can be expected to travel large distances through an elongate structural element; selecting a suitable mode of propagation and frequency of operation; designing a transducer that is adapted to excite the selected mode at the selected frequency; numerically modelling the transducer as attached to the elongate structural element; and analyzing a harmonic response of the selected mode of propagation to excitation by the transducer in order to validate the transducer design.

Abstract: The invention provides a crystalline Ti powder produced in a molten salt medium, said powder comprising predominantly particles of single ?-Ti crystals that are directly applicable in powder metallurgy.

Abstract: The invention provides a method of printing, onto a substrate (12), an array (14) of spots of reagent compositions for use in a chemical and/or biochemical analysis. The method includes displacing an array of reagent composition containing capillary tubes (22) arranged alongside one another from an inoperative position to an operative position in which open ends of the capillary tubes (22) simultaneously impinge against a substrate and thereafter displacing the array of tubes (22) from the operative position back to the inoperative position. The invention extends to a printing apparatus (10), a method of printing a layered array of spots of reagent compositions, a method of introducing reagent compositions into the tubes, a reagent introducing device for introducing reagent compositions into the tubes and a printing installation which includes the printing apparatus (10) and the reagent introducing device.

Abstract: This invention relates to a method for the production of proteins, preferably, heterologous proteins, under the regulation of the hp4d promoter, in Yarrowia lipolytica. In particular, this invention describes a method for manipulating the growth rate of Y. lipolytica by regulating the carbon and/or nitrogen supply. A growth rate of less than 0.045 h?1 was found to be optimal for increasing Y. lipolytica biomass and increasing the amount of heterologous proteins of interest produced.

Abstract: This invention relates to protein and/or polypeptide production, particularly improved production of extracellular heterologous polypeptides and proteins. In particular, the invention relates to compositions of cell populations capable of improved levels of extracellular secretion relative to control populations, kits containing such compositions, methods of producing heterologous proteins of interest and recombinant microorganisms capable of improved extracellular heterologous protein production.

Abstract: The present invention relates to a pharmaceutical composition for preventing and/or treating dementia comprising extracts of Monsonia sp.; a food composition for preventing and/or improving dementia comprising extracts of Monsonia sp.; and a method of preparing an extract of Monsonia sp. with excellent inhibitory effect on the formation of ?-amyloid. The plant extract can inhibit the formation of ?-amyloid which has been known as a factor causing the dementia, especially Alzheimer's disease, thereby being used for preventing, improving and/or treating the dementia.

Abstract: A process for the production of a substance or composition for the therapeutic or prophylactic treatment of erectile dysfunction or the enhancement of libido in a male human or animal subject comprises the step of formulating the substance or composition from at least one of plant material and an extract of plant material of at least one plant species of the family Geraniaceae.

Abstract: This invention relates to a method for the production of proteins, preferably, heterologous proteins, under the regulation of the hp4d promoter, in Yarrowia lipolytica. In particular, this invention describes a method for manipulating the growth rate of Y. lipolytica by regulating the carbon and/or nitrogen supply. A growth rate of less than 0.045 h?l was found to be optimal for increasing Y. lipolytica biomass and increasing the amount of heterologous proteins of interest produced.

Abstract: An in-shell egg pasteurization installation includes a temperature raising stage having a microwave cavity or microwave cavity portion into which microwaves can be radiated and a pasteurization stage having a microwave cavity or microwave cavity portion into which microwaves can be radiated. The installation is configured so as to provide radiant or conductive heat to an in-shell egg located in the temperature raising stage and to an in-shell egg located in the pasteurization stage, and to provide relative displacement between an in-shell egg and the microwave cavities or microwave cavity portions.

Abstract: A method of upgrading a titaniferous material includes nitriding and reducing a titaniferous material which includes TiO2 and Fe oxides in the presence of nitrogen and carbon to convert the TiO2 to TiN and to reduce most of the Fe oxides to Fe. The Fe is oxidised in preference to the TiN to form Fe2+ ions, whereafter the Fe2+ ions are removed to produce an upgraded low-Fe TiN bearing material.

Abstract: The invention provides a theft-inhibiting carrier which includes a body 12 having a chassis 16 on which three wheels 18 20 and 22 are mounted. The carrier 10 includes theft deterrent means 12. The theft deterrent means is configured, when activated, to dismount the wheels 20, 22 from their respective axles 44 but to retain them connected to the chassis 16 by an elongate flexible tether to impede the movement of the carrier. Two containers 60, 62 are provided and contain chemicals which are fed via pistons 68 to a mixing device 76 and into a valuables receiving chamber in which they foam and set thereby encasing valuables contained therein. A pair of arms 88 are pivotally displaced from a retracted position to an extended position in which they protrude from the containers 60, 62. Sharpened teeth 94 are provided on the arms to further inhibit displacement of the carrier.

Abstract: The invention provides a process for the production of nanoparticle carriers for drug delivery, said nanoparticles being produced by preparing a double emulsion of water-oil-water including one or more polymer which forms the basis of the nanoparticle carrier, blending the drug to be delivered into one of the emulsion phases, doping either the oil-phase or the outer-water phase with a carbohydrate, and spray drying the emulsion to form nanoparticles of a narrow particle size distribution of 100 nm to 1000 nm, which nanoparticles are substantially spherical.

Abstract: A method for assessing the integrity of a rock mass, the method including impacting the rock mass, capturing an acoustic signal generated as a result of the impact, deriving a frequency distribution for the captured acoustic signal, processing data from the frequency distribution by means of a neural network process applying artificial intelligence to assess the inputted data, and presenting a signal from the neural network process which is indicative of the integrity of the rock mass.

Abstract: The invention provides compounds of formula A or B which are useful in the treatment of a subject infected with HIV.

Abstract: An emulsion-derived particle comprises a lattice of polymeric strands cross-linked by means of a cross-linking agent, and interstitial openings adjacent and around the strands. Functional groups are provided on the lattice and proteins and/or modified proteins can react with these, thereby to be bonded to the lattice and hence immobilised.