Abstract: The present invention relates to an immunoglobulin preparation comprising immunoglobulin in a mass-volume percentage of at least 4%, wherein the concentration of oxygen dissolved in the preparation at room temperature is less than 40 ?mol/l.
Type:
Application
Filed:
July 14, 2022
Publication date:
March 16, 2023
Applicant:
CSL Behring AG
Inventors:
Werner Maeder, Reinhard Franz Bolli, Peter Lerch, Renzo Pedrussio, Liane Hoefferer
Abstract: The present invention relates to a method and a system of extracting a protein with high yield from a protein-comprising precipitate, in particular immunoglobulin, from human or non-human origins, such as blood plasma.
Abstract: The present invention relates to a method and system for extracting proteins from precipitates, particularly recombinant and/or plasma derived proteins including immunoglobulins (Ig) such as immunoglobulin G (IgG).
Type:
Application
Filed:
November 20, 2020
Publication date:
January 5, 2023
Applicant:
CSL BEHRING AG
Inventors:
Ibrahim EL MENYAWI, Marcus VON NORDHEIM
Abstract: The invention relates to methods for generating an aerosol by nebulization of a composition comprising polyclonal immunoglobulin (Ig). The selection of an efficient membrane nebulizer and a composition optimized for nebulization with such membrane nebulizer results in a particularly efficient method of generating an aerosol for administration of Ig to the respiratory tract.
Type:
Grant
Filed:
April 2, 2015
Date of Patent:
October 18, 2022
Assignees:
CSL BEHRING AG, PARI PHARMA GMBH, MEDIZINISCHE HOCHSCHULE HANNOVER
Inventors:
Cédric Pierre Vonarburg, Karin Steinfuehrer, Ulrich Baumann
Abstract: The present invention relates to an immunoglobulin preparation comprising immunoglobulin in a mass-volume percentage of at least 4%, wherein the concentration of oxygen dissolved in the preparation at room temperature is less than 40 ?mol/l.
Type:
Grant
Filed:
August 27, 2019
Date of Patent:
August 23, 2022
Assignee:
CSL Behring AG
Inventors:
Werner Maeder, Reinhard Franz Bolli, Peter Lerch, Renzo Pedrussio, Liane Hoefferer
Abstract: The present invention relates to a method and a system of extracting a protein with high yield from a protein-comprising precipitate, in particular immunoglobulin, from human or non-human origins, such as blood plasma.
Abstract: The present invention relates to a method and a system of extracting a protein with high yield from a protein-comprising precipitate, in particular immunoglobulin, from human or non-human origins, such as blood plasma.
Abstract: The present invention relates generally to a method of purifying proteins. More specifically, the present inventions relates to a method of purifying haptoglobin and hemopexin from the same starting material, and uses thereof.
Abstract: The invention relates to methods promoting the aggregation of Salmonella bacteria in the gut of subjects, thereby providing immune exclusion and limiting bacterial entry, therefore reducing mucosal and systemic infection.
Type:
Grant
Filed:
December 20, 2017
Date of Patent:
November 10, 2020
Assignees:
CSL BEHRING AG, CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Inventors:
Blaise Corthésy, Gilles Bioley, Cédric Pierre Vonarburg
Abstract: The present invention relates to an immunoglobulin preparation comprising immunoglobulin in a mass-volume percentage of at least 4%, wherein the concentration of oxygen dissolved in the preparation at room temperature is less than 40 ?mol/l.
Type:
Application
Filed:
August 27, 2019
Publication date:
February 20, 2020
Applicant:
CSL Behring AG
Inventors:
Werner Maeder, Reinhard Franz Bolli, Peter Lerch, Renzo Pedrussio, Liane Hoefferer
Abstract: The present invention relates to immunoglobulin products for use in the treatment of chronic inflammatory demyelinating polyneuropathy using immunoglobulin products. In particular, the present invention provides efficacious dosing regimens.
Type:
Application
Filed:
April 20, 2018
Publication date:
February 20, 2020
Applicant:
CSL BEHRING AG
Inventors:
ORELL MIELKE, JOHN-PHILIP LAWO, BILLIE DURN, MICHAEL TORTORICI, OTHMAR ZENKER, IVO VAN SCHAIK
Abstract: The invention relates to methods promoting the aggregation of Salmonella bacteria in the gut of subjects, thereby providing immune exclusion and limiting bacterial entry, therefore reducing mucosal and systemic infection.
Type:
Application
Filed:
December 20, 2017
Publication date:
November 14, 2019
Applicants:
CSL BEHRING AG, CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Inventors:
Blaise CORTHÉSY, Gilles BIOLEY, Cédric Pierre VONARBURG
Abstract: The present invention relates to an immunoglobulin preparation comprising immunoglobulin in a mass-volume percentage of at least 4%, wherein the concentration of oxygen dissolved in the preparation at room temperature is less than 40 ?mol/l.
Type:
Grant
Filed:
July 15, 2016
Date of Patent:
October 8, 2019
Assignee:
CSL Behring AG
Inventors:
Werner Maeder, Reinhard Franz Bolli, Peter Lerch, Renzo Pedrussio, Liane Hoefferer
Abstract: The invention relates to methods for preparing compositions comprising secretory-like immunoglobulin, in particular secretory-like IgA and/or secretory-like IgM, and compositions obtainable by the methods.
Type:
Grant
Filed:
March 8, 2013
Date of Patent:
March 5, 2019
Assignee:
CSL BEHRING AG
Inventors:
Blaise Corthésy, Stéphanie Longet, Marius Loetscher, Sylvia Miescher, Adrian Zuercher
Abstract: The invention relates to a modified process for the purification of IgG, improving the yield of IgG per liter of starting material without compromising the quality of the product.
Abstract: The present invention relates generally to a method of purifying proteins. More specifically, the present inventions relates to a method of purifying haptoglobin and hemopexin from the same starting material, and uses thereof.
Abstract: The invention relates to compositions and methods to prevent enteric infection in a subject at risk of such infection. In particular, the invention relates to the prevention of recurrence of infection by Clostridium difficile.
Type:
Grant
Filed:
March 8, 2013
Date of Patent:
April 3, 2018
Assignees:
CSL BEHRING AG, BETH ISRAEL DEACONESS MEDICAL CENTER INC
Inventors:
Ciaran Kelly, Xinhua Chen, Sylvia Miescher, Martin Spycher, Sandra Wymann, Adrian Zuercher