Patents Assigned to CSL Limited
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Patent number: 7476389Abstract: A method of providing papilloma virus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in related to infections caused by papilloma virus. The method includes an initial step of constructing one or more recombinant DNA molecules which each encode papilloma virus L1 protein or a combination of papilloma virus L1 protein and papilloma virus L2 protein followed by a further step of transfecting a suitable host cell with one or more of the recombinant DNA molecules so that virus like particles (VLPs) are produced within the cell after expression of the L1 or the combination of L1 and L2 proteins. The VLPs are also claimed per se as well as vaccines incorporating the VLPs.Type: GrantFiled: July 20, 1992Date of Patent: January 13, 2009Assignees: The University of Queensland, CSL LimitedInventors: Ian Frazer, Jian Zhou
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Patent number: 7423016Abstract: The present invention provides methods of enhancing the immune response to an immunogen and to compositions for use in these methods. In particular the present invention provides a DNA molecule for use in raising an immune response to an antigen. The DNA molecule includes a first sequence encoding a targeting molecule, a second sequence encoding the antigen or an epitope thereof, and optionally a third sequence encoding a polypeptide which promotes dimerization or multimerization of the product encoded by the DNA molecule.Type: GrantFiled: June 28, 2002Date of Patent: September 9, 2008Assignee: CSL, LimitedInventors: Jeffrey Stephen Boyle, Jamie Louise Brady, Andrew Mark Lew
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Patent number: 7423023Abstract: The present invention provides methods of enhancing the immune response to an immunogen and to compositions for use in these methods. In particular the present invention provides a DNA molecule for use in raising an immune response to an antigen. The DNA molecule includes a first sequence encoding a targeting molecule, a second sequence encoding the antigen or an epitope thereof, and optionally a third sequence encoding a polypeptide which promotes dimerization or multimerization of the product encoded by the DNA molecule.Type: GrantFiled: June 28, 2002Date of Patent: September 9, 2008Assignee: CSL, LimitedInventors: Jeffrey Stephen Boyle, Jamie Louise Brady, Andrew Mark Lew
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Publication number: 20080214434Abstract: A method for the treatment of endothelial dysfunction in a diabetic patient, including both diabetes induced macrovascular disorders and diabetes induced microvascular disorders, comprises administration, preferably parenteral administration, to the patient of an effective amount of high density lipoprotein (HDL).Type: ApplicationFiled: March 1, 2007Publication date: September 4, 2008Applicant: CSL LimitedInventor: Erik S.G. Stroes
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Patent number: 7419671Abstract: The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.Type: GrantFiled: June 18, 2002Date of Patent: September 2, 2008Assignees: CSL Limited, The University of MelbourneInventors: Eric Charles Reynolds, Nada Slakeski, Chao Guang Chen, Ian George Barr
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Publication number: 20080175867Abstract: The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.Type: ApplicationFiled: March 27, 2007Publication date: July 24, 2008Applicants: CSL Limited, The University of MelbourneInventors: Eric C. Reynolds, Nada Slakeski, Chao Guang Chen, Ian George Barr
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Publication number: 20070248615Abstract: The present invention provides T helper cell epitopes and compositions for use in inducing an immune response comprising at least one of these epitopes.Type: ApplicationFiled: June 19, 2007Publication date: October 25, 2007Applicants: CSL Limited, The University of Melbourne, Commonwealth Scientific and Industrial Research Organisation, The Council of Queensland Institute of Medical Reseach, Walter and Eliza Hall Institute of Medical ResearchInventors: David Jackson, Souravi Ghosh, John Walker
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Patent number: 7262271Abstract: The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease.Type: GrantFiled: March 12, 2003Date of Patent: August 28, 2007Assignees: CSL Limited, The University of MelbourneInventors: Eric C. Reynolds, Neil Martin O'Brien-Simpson, Nada Slakeski
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Publication number: 20070189981Abstract: The present invention relates to isolated Porphorymonas gingivalis polypeptides and nucleotides. The polypeptides include; an amino acid sequence selected from the group consisting of SEQ. ID. NO. 265 to SEQ. ID. NO. 528, SEQ. ID. NO. 531 and SEQ. ID. NO. 532; or an amino acid sequence at least 85%, preferably at least 95%, identical to an amino acid sequence selected from the group consisting of SEQ. ID. NO. 265 to SEQ. ID. NO. 528, SEQ. ID. NO. 531 and SEQ. ID. NO. 532; or at least 40 amino acids having a contiguous sequence of at least 40 amino acids identical to a contiguous amino acid sequence selected from the group consisting of SEQ. ID. NO. 265 to SEQ. ID. NO. 528, SEQ. ID. NO. 531 and SEQ. ID. NO. 532.Type: ApplicationFiled: October 30, 2006Publication date: August 16, 2007Applicant: CSL LimitedInventors: Bruce Ross, Ian Barr, Michelle Patterson, Catherine Agius, Linda Rothel, Mai Margetts, Dianna Hocking, Elizabeth Webb
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Publication number: 20070129320Abstract: The invention relates to TLR ligand formulations that comprise immune stimulating complexes and their use in inducing innate immunity.Type: ApplicationFiled: July 18, 2005Publication date: June 7, 2007Applicants: Coley Pharmaceutical Group, Ltd., CSL LimitedInventors: Heather Davis, Michael McCluskie, Debra Drane
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Patent number: 7204991Abstract: The present invention relates to soluble P. gingivalis polypeptides derived from PG32 and PG33 and to polynucleotides encoding these polypeptides. The P. gingivalis polypeptides and nucleotides can be used in compositions for use in raising an immune response in a subject against P. gingivalis and treating or preventing or reducing the severity of the condition known as periodontitis or in other conditions related to infection with P. gingivalis.Type: GrantFiled: October 28, 2002Date of Patent: April 17, 2007Assignee: CSL LimitedInventors: Ian George Barr, Larissa Czajkowski, Bruce Carter Ross
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Patent number: 7169585Abstract: A method of providing papillomavirus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in relation to infections causd by papillomavirus. The method includes an initial step of constructing one or more recombinant DNA molecules which each encode papillomavirus L1 protein or a combination of papillomavirus L1 protein and papillomavirus L2 protein followed by a further step of transfecting a suitable host cell with one or more of the recombinant DNA molecules so that virus like particles (VLPs) are produced within the cell after expression of the L1 or combination of L1 and L2 proteins. The VLPs are also claimed per se as well as vaccines incorporating the VLPs.Type: GrantFiled: December 11, 2003Date of Patent: January 30, 2007Assignees: University of Queensland, CSL LimitedInventors: Ian Frazer, Jian Zhou
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Patent number: 7114617Abstract: A container for a relatively brittle product, such as a haemostatic bandage, including a body and a lid for closing the container to hermetically seal the product therein. A sealing rim of the lid includes a layer of elastomeric material which sealingly engages with a sealing rim of the container body to provide a first, static, seal and a second, dynamic, seal. The elastomeric sealing material extends into the interior of the container beneath the lid to provide an elastomeric formation operative to engage an upper surface of the product within the container so as to apply a resilient bias thereto to hold a lower face of the product against the base of the container. The elastomeric formation thereby acts to inhibit substantial movement of the product within the container.Type: GrantFiled: July 2, 2003Date of Patent: October 3, 2006Assignee: CSL LimitedInventors: Gary Wayne Yewdall, Jillian Louise Isabel Mahon, Paul Murray Malouf, Mark Simon Bayly, Peter Kinglsey Bayly
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Publication number: 20060204514Abstract: Methods are disclosed for the design of non-native (i.e. heterologous) polypeptides comprising a proportion of hydrophobic amino acids which have an increased probability of being efficiently expressed in an expression system such as a bacterial host (e.g. E. coli). The methods involve identifying one or more hydrophobic peptide sequences within a polypeptide of interest, and arranging or re-locating at least one of the hydrophobic peptide sequences within said polypeptide so as to generate a candidate polypeptide with reduced amplitude in hydrophobicity and/or length of any hydrophobic region(s). Such methods are particularly useful for designing polyepitope polypeptides, and specific examples of such are described for Epstein-Barr virus (EBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV).Type: ApplicationFiled: July 14, 2003Publication date: September 14, 2006Applicants: CSL Limited, The Council of the Queensland Institute of Medical ResearchInventors: Elizabeth Webb, Peter Schoofs
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Publication number: 20060199177Abstract: The present invention provides T helper cell epitopes and compositions for use in inducing an immune response comprising at least one of these epitopes. The epitopes are contained within a peptide sequence selected from the group consisting of EPINQALTLMTKNVKPL (SEQ ID NO: 12); FAGVVLAGVALGVATAA (SEQ ID NO: 13); NLNAQAIQSLRTSLEQS (SEQ ID NO: 17) and TELLSIFGPSLRDPISA (SEQ ID NO: 20).Type: ApplicationFiled: May 4, 2006Publication date: September 7, 2006Applicants: CSL Limited, The University of Melbourne, Commonwealth Scientific and Industrial Research Organisation, The Council of Queensland Institute of Medical Research, Walter and Eliza Hall Institute of Medical ResearchInventors: David Jackson, Souravi Ghosh, John Walker
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Patent number: 7097844Abstract: The present invention provides T helper cell epitopes and compositions for use in inducing an immune response comprising at least one of these epitopes. The epitopes are contained within a peptide sequence selected from the group consisting of PRTSDRPVSYTMNRTRS (SEQ ID NO: 4); TRSRKQTSHRLKNIPVH (SEQ ID NO: 5); SHQYLVIKLIPNASLIE (SEQ ID NO: 6); and SPDKLLTFIASDTCPLV (SEQ ID NO: 25).Type: GrantFiled: November 13, 2003Date of Patent: August 29, 2006Assignees: CSL Limited, The University of Melbourne, Commonwealth Scientific and Industrial Research Organisation, The Council of Queensland Institute of Medical Research, Walter and Eliza Hall Institute of Medical ResearchInventors: David Charles Jackson, Souravi Ghosh, John Walker
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Patent number: 7089001Abstract: A method of automatically establishing a roaming service for a mobile telephone, that includes a pre-programmed SIM card, performs a Location Update in the following order. 1. Registered Public Land Mobile Network (“RPLMN”), i.e. the last registered network as stored in the SIM directory EFLOCI (EF6F7E). 2. Home PLMN (“HPLMN”) 3. PLMNs contained in a “PLMN Selector” data field based on the “Operator List”. 4. User-defined preferred PLMN 5. Other PLMNs with received signal level above a predetermined strength in random order; and 6. All other PLMNs in order of descending signal strength.Type: GrantFiled: September 11, 2001Date of Patent: August 8, 2006Assignee: Hong Kong CSL LimitedInventors: Edward Yan Tao Leung, Richard Midgett, Kwok Wing Yau
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Patent number: 7037507Abstract: The present invention provides T helper cell epitopes and compositions for use in inducing an immune response comprising at least one of these epitopes. The epitopes are contained within a peptide sequence selected from the group consisting of SSKTQTHTQQDRPPQPS (SEQ ID NO: 1); QPSTELEETRTSRARHS (SEQ ID NO: 2); QSLRTSLEQSNKAIEEI (SEQ ID NO: 18); and DESSCVFVSESAICSQN (SEQ ID NO: 23).Type: GrantFiled: September 8, 2004Date of Patent: May 2, 2006Assignees: CSL Limited, The University of MelbourneInventors: David Charles Jackson, Souravi Ghosh, John Walker
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Publication number: 20060019923Abstract: The invention relates to TLR ligand formulations that comprise immune stimulating complexes and their use in inducing innate immunity.Type: ApplicationFiled: July 18, 2005Publication date: January 26, 2006Applicants: Coley Pharmaceutical Group, Ltd., CSL LimitedInventors: Heather Davis, Michael McCluskie, Debra Drane
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Patent number: 6962706Abstract: This invention relates to a peptide selected from the group: FLLDADHNTFGSVIPATGPLFTGTASS LYSANFESLIPANADPVVTTQNIIVTG LYSANFEYLIPANADPVVTTQNIIVTG TNPEPASGKMWIAGDGGNQP RYDDFTFEAGKKYTFTMRRAGMGDGTD DDYVFEAGKKYHFLLLMKKMGSGDGTE TNPEPASGKMWIAGDGGNQPARYDDFTFEAGKKYTFTMRRAGMGDGTD NTFGSVIPATGPL PASGKMWIAGDG EAGKKYTFTMRRA EAGKKYHFLMKKM. It also relates to compositions and use of these peptides for treating and testing Porphyromonas gingialis.Type: GrantFiled: March 1, 2000Date of Patent: November 8, 2005Assignees: The University of Melbourne, CSL Limited, Victorian Dairy Industry AssociationInventors: Neil Martin O'Brien-Simpson, Eric Charles Reynolds