Abstract: A cell separation control apparatus may include a separation disc having a plurality of chambers and configured to separate a target material from a sample by means of a centrifugal force generated by a rotation, a printed circuit board coupled to the separation disc and having heating terminals configured to transfer heat to valves in channels that connect the plurality of chambers of the separation disc, and a plurality of pressing parts provided on the printed circuit board and configured to transfer heat from the heating terminals to the valves by pressing the heating terminals toward the valves.
Abstract: The present invention relates to a cytokine trimer domain in which a first monomer and a second monomer linked by linker (dimer) and a third monomer are coupled by a knob-into-hole and a novel type of fusion protein in which antibody and cytokine trimer domains are linked (receptor-antibody conjugated (cell) engager, RACE) prepared by replacing a constant region (Fc) of an antibody with the cytokine trimer domain, and RACE according to the present invention exhibits superior binding ability to the target receptor than the parent antibody as well as excellent simultaneous binding ability to the antigen and the target receptor, which can be usefully utilized as a bispecific pharmaceutical composition.
Type:
Grant
Filed:
June 22, 2022
Date of Patent:
October 22, 2024
Assignee:
CTCELLS, INC.
Inventors:
Kka Bi Son, Jeong Hyeon Bak, Dae Hee Lee, Se Il Jang, Jung Min Lee, Ji Hye Yoon, Jong Gwan Jeong