Abstract: Embodiments of this disclosure comprise of an optical cube, a light source, a cube holder connection point, a plurality of pins, a plurality of cavities sized and configured to receive said pins, a magnet, and a magnetic element located to attract and adhere to said magnet. An optical device with coaxial illumination for reflected light and fluorescence detection includes one or more optical cubes to redirect light along the optical axis. The cube holder connection point can be in a fixed position, moved translationally, or moved rotationally to engage a cube within the optical device. An optical cube can be attached to the cube holder connection point utilizing locating pins and magnetic coupling to constrain all 6 degrees of freedom. Use of such devices reduces the need to use screws or other locking hardware and permits a larger number of optical cubes to be inserted in the same area and makes it easier to exchange optical cubes.

Abstract: Embodiments of the present invention relate to devices and methods for detecting cellular products using detection particles having product-specific detection reagents and having a characteristic spectral feature. In particular, devices and methods are provided for measuring secreted cellular products including cytokines. Detection substrates, include microwells having product-specific capture reagents thereon or comprising hydrophobic membranes are described having greater capability to detect products from individual cells in a mixture of heterogeneous cells. With the use of multiple detection particles, multiple cellular products can be detected in a single well. Additionally, using the inherent spectral properties of detection particles, no enzymatic reactions are needed to visualize a secreted product, thereby increasing the sensitivity, reproducibility and ease of use.

Abstract: Embodiments include systems and methods for summoning help and locating a person, comprising transmitting information over a wireless network in response to a user action; wherein the information includes the geographic location of the user.

Abstract: Embodiments of the present invention relate to devices and methods for detecting cellular products using detection particles having product-specific detection reagents and having a characteristic spectral feature. In particular, devices and methods are provided for measuring secreted cellular products including cytokines. Detection substrates, include microwells having product-specific capture reagents thereon or comprising hydrophobic membranes are described having greater capability to detect products from individual cells in a mixture of heterogeneous cells. With the use of multiple detection particles, multiple cellular products can be detected in a single well. Additionally, using the inherent spectral properties of detection particles, no enzymatic reactions are needed to visualize a secreted product, thereby increasing the sensitivity, reproducibility and ease of use.