Abstract: The present invention is concerned with an improved process for the resolution of racemic 2-(o-chlorophenyl)-2-methylaminocyclohexanone (ketamine).
Type:
Grant
Filed:
November 10, 1998
Date of Patent:
March 21, 2000
Assignees:
Goedecke Aktiengesellschaft, Cu Chemie Uetikon GmbH
Inventors:
Klaus Steiner, Stefan Gangkofner, Jean-Marie Grunenwald
Abstract: A crystalline polymorphous terazosine monohydrochloride is obtained by suspending and treating a crystalline addition product of terazosine hydrochloride and methanol in a polar solvent which is an alcohol with 2 to 6 carbon atoms or a ketone with 2 to 6 carbon atoms or a mixture thereof. The thus obtained crystalline polymorphous terazosine hydrochloride is characterized by a reduced hygroscopicity and solvent residue retention capacity.
Type:
Grant
Filed:
June 10, 1998
Date of Patent:
September 28, 1999
Assignee:
Cu Chemie Uetikon GmbH
Inventors:
Christophe Bauer, Jean-Marie Grunenwald