Abstract: The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of Streptomyces roseosporus. The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.
Type:
Grant
Filed:
September 2, 2014
Date of Patent:
June 7, 2016
Assignee:
Cubist Pharmaceuticals LLC
Inventors:
Thomas J. Kelleher, Jan-Ji Lai, Joseph P. DeCourcey, Paul D. Lynch, Maurizio Zenoni, Auro R. Tagliani
Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.
Type:
Application
Filed:
August 12, 2015
Publication date:
February 4, 2016
Applicant:
CUBIST PHARMACEUTICALS LLC
Inventors:
Sandra O'Connor, Sophie Sun, Gaauri Naik
Abstract: The present disclosure provides novel powder daptomycin formulations which have improved chemical stability and faster reconstitution times when in the solid state. Some examples of the compositions comprise daptomycin and sucrose.
Type:
Grant
Filed:
December 4, 2013
Date of Patent:
September 22, 2015
Assignee:
Cubist Pharmaceuticals LLC
Inventors:
Sandra O'Connor, Sophie Sun, Gaauri Naik