• Patent number: 11684603
    Abstract: Disclosed are methods for ameliorating glycocalyx damage by administering a neuraminidase inhibitor. Also disclosed are methods for treating endothelial dysfunction and for improving flow mediated dilation.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: June 27, 2023
    Inventors: Luis A. Martinez-Lemus, Christopher A. Foote, Jaume Padilla
  • Patent number: 9771577
    Abstract: The present invention relates to compositions and methods useful for analyzing lariat RNA, which plays a role in the regulation of gene expression. A sample of RNA is specifically treated to remove linear mRNA and enrich for lariat RNA. The enriched lariat RNA sample may be analyzed further to identify introns, branch point sequences, alternative splicing patters, and gene transcription levels. The enriched lariat RNA sample may also be exploited as a detection or compound screening tool, as well as other uses.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: September 26, 2017
    Inventor: Thomas Matthew Menees
  • Patent number: 8501319
    Abstract: A composite material that includes a dopant comprised of pre-formed, three dimensional assemblies of skeletal structures that are comprised of solgel derived nanoparticles. The composite material includes a chemically bonded, in situ formed, polymer coating that at least partially coats mesoporous surfaces of the nanoparticles to provide enhancement of random dispersion of the dopant and to minimize or avoid agglomeration. Further, the polymer may be functionalized or the mesoporous surfaces of the nanoparticles may be treated to enable stronger chemical bonding between the dopant and the polymer.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: August 6, 2013
    Assignee: The Curators of the University of Missouri, University of Missouri System, Office of Technology and Special Projects
    Inventors: Nicholas Leventis, Chariklia Sotiriou-Leventis
  • Patent number: 8426154
    Abstract: Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an antibody that specifically binds to an antigenic site on venom present in the sample. Binding is then detected. The invention is illustrated by examples showing diagnosis of brown recluse spider bite, distinguishing it from other diagnoses with which it is often confused. This extremely sensitive test can detect venom antigens down to about 20 picograms even after the sample has been shipped and stored for periods of up to three weeks during the summer.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: April 23, 2013
    Assignees: SpiderTech, a Division of Stoecker & Associates, a Subsidiary of The Dermatology Center, LLC., The Regents of the University of Michigan, Office of Technology Transfer, The Curators of the University of Missouri, University Hall, The United States of America as Represented by the Secretary of the Air Force, Directorate of Intellectual Property Law
    Inventors: William V. Stoecker, Hernan F. Gomez, Jonathan A. Green, David L. McGlasson
  • Patent number: 7695450
    Abstract: A catheter for hemodialysis comprises a flexible catheter tube defining a plurality of separate lumens. The catheter defines an arc angle of generally U-shape in its natural, unstressed configuration. Thus, the catheter may be implanted with a distal catheter portion residing in a vein of the patient, the distal catheter portion being of substantially the shape of the vein in its natural, unstressed condition. Also, a proximal catheter portion resides in a surgically created tunnel extending from the vein and through the skin of the patient, this section of the catheter also being typically in its natural, unstressed condition. Thus blood may be removed from the vein through one lumen of the catheter, and blood may be returned to the vein through another lumen of the catheter, while the catheter is subject to long term indwelling in the body.
    Type: Grant
    Filed: March 28, 1995
    Date of Patent: April 13, 2010
    Assignee: Curators of the University of Missouri, The University of Missouri
    Inventors: Zbylut J. Twardowski, John C. Van Stone, W. Kirt Nichols