Abstract: A mobile robot system and method for determining the stiffness of a human arm while moving with a user during overground interaction as the user holds the robot's handle and exchanges forces with it. A mobile base moves with the user, a robot arm interacts with the user, and a controller determines the stiffness. The robot arm includes servomotors driving a linkage mechanism, an end effector including the handle supported by the linkage mechanism, and a force transducer measuring a force applied by the user to the handle. The controller causes the robot arm to generate a force perturbation at the handle, measure a peak velocity achieved by the human arm, determine the stiffness of the human arm as a function of force and displacement, and control operation of the system based on the determined stiffness. A robot body may allow for adjusting the height of the robot arm.

Abstract: The present invention is directed to processes for ionizing one or more lanthanide isotopes, processes for separating lanthanide isotopes, various apparatus and systems useful for these processes, and compositions prepared from these processes.

Abstract: Provided herein are methods and compositions for sensitizing a cancer cell to a cancer treatment, for example to an anticancer drug by the inhibition of at least two cancer biomarkers. Further provided are methods of treating and/or preventing a cancer including reducing the size of a tumor. Also provided are compositions comprising nanopartides associated with inhibitory molecules, such as siRNA, and/or anti-cancer drugs.

Abstract: Methods and compositions for treating cancer are provided. Compositions comprising ceramide nanoliposomes are administered to a subject in need of such treatment. The composition administration also enhances immunotherapy. Further administering compositions in combination with tumor antigen specific T-cells, and/or compositions in combination with tumor antigen expressing cells, and/or said compositions in combination with antagonists of PD-1 provides for enhanced results. Administration of the compositions provides for effective treatment of tumors including regression and eradication of established tumors.

Abstract: A class of design topologies in the field of nonlinear networks (NLN) or nonlinear transmission lines (NLTL) that re-utilize direct current (DC) and low-frequency (LF) signal content reflected from a load or an output filter to yield increased pulse to radio frequency conversion efficiency and increased overall system efficiency. A nonlinear transmission line topology comprises a plurality of series inductive elements and a plurality of nonlinear capacitive elements. The inductive elements and the capacitive elements are arranged in a periodic structure forming a nonlinear network. An output coupling circuit connected across an output of the nonlinear network is configured to transmit high-frequency content to a load and to reflect back direct current and low-frequency content into the nonlinear network.

Abstract: The present invention relates to various high quality n-type and p-type doped gallium-based semiconductor materials, electronic components incorporating these materials, and processes of producing these materials. In particular, The present invention relates processes to achieve high quality, uniform doping of a whole wafer or a thin layer of gallium-based semiconductor materials for various applications such as a vertical power transistor or diode.

Abstract: This invention is broadly concerned with compositions and processes for oilfield applications. More specifically, this invention relates to novel polymer constructed packages that, when pumped into a petroleum well, provide tunable characteristics of transformation and delayed self-assembly with each other under reservoir conditions to yield strong, elastic, bulk gel materials. The compositions comprise a polymer, assembling agents, and optional additives used for the re-assembly stage are uniformly-distributed within the initial gel particles. The polymer particle packages absorb water and swell upon exposure to water, thus exposing the “assembling agents” that enable re-assembly. Both swelling and re-assembly are proportionally controlled via compositions to be tunable to allow functional dispersion and subsequent self-assembly under various reservoir conditions.

Abstract: Ayurvedic encapsulated gold nanoparticles, methods of fabrication and methods of treatment are provided. A method of fabrication includes mixing dried gooseberry product or mango peel product or phytochemical existent therein, into a liquid medium to form a reducing agent solution. Gold salts are mixed into the reducing agent solution. Reaction of the gold salts proceeds, in the absence of any other reducing agent, to form a nanoparticle solution of stabilized, biocompatible Ayurvedic encapsulated gold nanoparticles. An Ayurvedic medicine consists of a non-radioactive gold nanoparticle encapsulated with phytochemical existent in mango peal or gooseberry in a capsule with curcumin extract and gum Arabic.

Abstract: An elastic wave cloaking lattice-based metamaterial for cloaking an object within a void includes a lattice of connected unit cells arranged to form a void, each unit cell comprising a mass and a plurality of connecting springs, the mass coupled by the plurality of connecting springs to masses in adjacent unit cells, the plurality of connecting springs comprising at least two large springs of a first length and at least two short springs of a second length, the first length greater than the second length, the springs and masses having relational and mechanical characteristics to facilitate elastic wave cloaking in the totality of the lattice. The lattice as a whole has metamaterial properties resulting from the positional relationship and mechanical properties of masses and connecting springs of the unit cells such that the lattice at least partially cloaks an object or material portioned within the void from elastic waves.

Abstract: A method for forming crystalline solid dispersions (CSDs) of a pharmaceutical agent with low water solubility is described. The properties of the CSDs are described. Also described is the enhancement of bioavailability of the pharmaceutical agent resulting from formation of the CSD.

Abstract: One aspect of the present invention is directed to a granular filter media for removing contaminants from water or other liquids. The media comprise granular materials comprising aggregate and remediation materials. Other aspects of the invention are directed to methods of making and using the granular filter media of the invention.

Abstract: Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion.

Abstract: Doped nitride-based semiconductor materials and methods of producing these materials are described herein.

Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.

Abstract: Methods and apparatuses for using the impedance inhomogeneity pattern (IIP) of a transmission line, or one or more segments thereof, to verify the identity of the transmission line and/or detect whether or not the transmission line has been altered or tampered with. Because the impedance inhomogeneity pattern of a transmission line is unique, unpredictable, and uncontrollable, it can be used as a physical unclonable function (PUF). The IIP can be obtained by a method such as frequency domain reflectometry or time domain reflectometry, and is then compared with a previously stored intrinsic IIP obtained from a transmission line (or segment(s)) prior to first use through the use of, for example, correlation or coherence functions. The method can be used on any transmission line, including electrical, optical and acoustic transmission lines.

Abstract: A water production system including a radiative cooling/heating unit comprising an oscillating heat pipe (OHP) heat spreader. The radiative cooling/heating unit lowers the temperature of the OHP heat spreader below the temperature of the ambient environment. The system additionally including a first OHP heat exchanger thermally connected to the OHP heat spreader such that the first OHP heat exchanger will acquire substantially the same temperature as the OHP heat spreader, a second OHP heat exchanger thermally connected to the OHP heat spreader such that the second OHP heat exchanger will acquire substantially the same temperature as the OHP heat spreader, and a rotatable OHP water absorption bed disposed in thermal contact with the radiative cooling/heating unit such that the OHP absorption bed will acquire substantially the same temperature as the OHP heat spreader.

Abstract: This disclosure relates to synthetic ligands for detecting PD-L1 in a sample or subject. The ligand can be labeled with a variety of detectable labels allowing of visualization and quantification. The ligand provides an alternative PD-L1 binding molecule with advantages over current antibody technologies for detecting PD-L1.

Abstract: Improved sensor compositions comprising a dye are provided. The compositions are generally characterized by at least partially immobilizing the dye on polymeric microparticles and dispersing in a dispersion medium. The dye may comprise an oxygen, humidity, carbon dioxide, temperature, or pH-responsive dye. Also provided is a sensor patch comprising a substrate and the sensor composition comprising a dye.

Abstract: The present disclosure generally relates to smart bandages comprising a dressing and pressure sensor. The pressure sensor measures at least one pressure reading at a wound area while the dressing bandages the wound area. The pressure sensor includes a force sensitive film configured to generate a pressure signal based on pressure applied thereto and is operably coupled to the dressing such that pressure applied to the wound area is coupled to the force sensitive film via the dressing. A near field communication device of the pressure sensor is operably coupled to the force sensitive film for reporting the pressure signal. The smart bandage may include a user interface that is configured to display reported signals to a user for comparing the pressure at the wound area with a threshold pressure. The disclosure further provides a method of treating the wound area by applying the smart bandage to the wound area.

Abstract: A method for forming encapsulated gold nanoparticles mixes mangiferin into a liquid medium to form a reducing agent solution. Gold salts are mixed into the reducing agent solution. Reaction of the gold salts is permitted, in the absence of any other reducing agent, to form a nanoparticle solution of stabilized, biocompatible gold nanoparticles coated with mangiferin. The gold salts can consist of AuCl4, or can consist of radioactive gold salts. A cancer therapy method injects a solution of mangiferin encapsulated gold nanoparticles directly into a solid tumor. A solution consisting of an aqueous or alcoholic medium and mangiferin encapsulated gold nanoparticles is provided. The mangiferin encapsulated gold nanoparticles can have core sizes of ˜5-20 nm and total sizes of ˜20-120 nm.