Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of a gene that weakens the function of the immune cell.
Type:
Grant
Filed:
March 22, 2022
Date of Patent:
April 29, 2025
Assignees:
CUROCELL INC., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Chan Hyuk Kim, Young-Ho Lee, Yujean Lee, HyeongJi Lee, Sang Hoon Lee
Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of a gene that weakens the function of the immune cell.
Type:
Application
Filed:
May 15, 2023
Publication date:
November 30, 2023
Applicants:
CUROCELL, INC., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Chan Hyuk KIM, Young-Ho LEE, Yujean LEE, HyeongJi LEE, Sang Hoon LEE
Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of a gene that weakens the function of the immune cell.
Type:
Grant
Filed:
January 10, 2019
Date of Patent:
June 20, 2023
Assignees:
CUROCELL, INC., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Chan Hyuk Kim, Young-Ho Lee, Yujean Lee, HyeongJi Lee, Sang Hoon Lee
Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of a gene that weakens the function of the immune cell.
Type:
Application
Filed:
March 22, 2022
Publication date:
November 3, 2022
Applicants:
CUROCELL INC., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Chan Hyuk KIM, Young-Ho LEE, Yujean LEE, HyeongJi LEE, Sang Hoon LEE, Sang Hoon LEE
Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of two genes that weaken the function of the immune cell.
Type:
Application
Filed:
July 16, 2020
Publication date:
November 3, 2022
Applicants:
CUROCELL INC., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Gun Soo KIM, Mi Kyung KIM, Chan Hyuk KIM, Young-Ho LEE, HyeongJi LEE
Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of a gene that weakens the function of the immune cell.
Type:
Application
Filed:
March 18, 2021
Publication date:
August 26, 2021
Applicants:
CUROCELL INC., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Chan Hyuk KIM, Young-Ho LEE, Yujean LEE, HyeongJi LEE, Sang Hoon LEE
Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present invention generally relates to an immune cell comprising a genetically engineered antigen receptor that specifically binds to a target antigen and a genetic disruption agent that reduces or is capable of reducing the expression in the immune cell of a gene that weakens the function of the immune cell.
Type:
Application
Filed:
January 10, 2019
Publication date:
March 4, 2021
Applicants:
CUROCELL INC., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Chan Hyuk KIM, Young-Ho LEE, Yujean LEE, HyeongJi LEE, Sang Hoon LEE