Patents Assigned to Currax Pharmaceuticals LLC
  • Low-Dose Doxepin For Treatment Of Sleep Disorders In Elderly Patients
    Publication number: 20220151975
    Abstract: Methods of treating sleep disorders, particularly certain aspects of insomnia, in elderly patients (65 years and older) by administering initial daily dosages of doxepin of 1-3 mg. These ultra-low initial dosages are more effective in elderly versus non-elderly patients in decreasing wake time during sleep, latency to persistent sleep and wake time after sleep, and are particularly efficacious in treating those conditions in the last hour of an 8-hour sleep cycle. Also, the dosages described herein are safe for elderly individuals.
    Type: Application
    Filed: January 31, 2022
    Publication date: May 19, 2022
    Applicants: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Roberta L. Rogowski, Susan Ellen Dube, Philip Jochelson, Neil B. Kavey
  • Low-Dose Doxepin Formulations And Methods Of Making And Using The Same
    Publication number: 20220110908
    Abstract: The invention disclosed herein generally relates to low-dose oral doxepin pharmaceutical formulations and the use of these formulations to promote sleep.
    Type: Application
    Filed: August 23, 2021
    Publication date: April 14, 2022
    Applicant: Currax Pharmaceuticals LLC
    Inventors: Luigi Schioppi, Brian Talmadge Dorsey, Michael Skinner, John Carter, Robert Mansbach, Philip Jochelson, Roberta L. Rogowski, Cara Baron Casseday, Meredith Perry, Bryan Knox
  • Low-dose doxepin for treatment of sleep disorders in elderly patients
    Patent number: 11234954
    Abstract: Methods of treating sleep disorders, particularly certain aspects of insomnia, in elderly patients (65 years and older) by administering initial daily dosages of doxepin of 1-3 mg. These ultra-low initial dosages are more effective in elderly versus non-elderly patients in decreasing wake time during sleep, latency to persistent sleep and wake time after sleep, and are particularly efficacious in treating those conditions in the last hour of an 8-hour sleep cycle. Also, the dosages described herein are safe for elderly individuals.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: February 1, 2022
    Assignee: Currax Pharmaceuticals LLC
    Inventors: Roberta L. Rogowski, Susan Ellen Dube, Philip Jochelson, Neil Barton Kavey
  • Methods Of Improving The Pharmacokinetics Of Doxepin
    Publication number: 20210393567
    Abstract: Methods of improving the pharmacokinetics of doxepin in a patient.
    Type: Application
    Filed: September 6, 2021
    Publication date: December 23, 2021
    Applicant: Currax Pharmaceuticals LLC
    Inventors: Cara Baron Casseday, Elizabeth Ludington, Michael Skinner, Susan E. Dubé, Roberta L. Rogowski, Philip Jochelson, Robert Mansbach
  • COMBINATION THERAPY USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP
    Publication number: 20210283094
    Abstract: A composition comprising doxepin, or a pharmaceutically acceptable salt, or prodrug thereof, and a compound that enhances sleep onset, sleep maintenance or reduces early morning awakenings. These compositions are useful for treating multiple manifestations of insomnia.
    Type: Application
    Filed: May 24, 2021
    Publication date: September 16, 2021
    Applicants: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Philip Jochelson, Robert Mansbach, Michael Skinner, Neil B. Kavey
  • Methods of improving the pharmacokinetics of doxepin
    Patent number: 11110074
    Abstract: Methods of improving the pharmacokinetics of doxepin in a patient.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: September 7, 2021
    Assignee: Currax Pharmaceuticals LLC
    Inventors: Cara Baron Casseday, Elizabeth Ludington, Michael Skinner, Susan E. Dubé, Roberta L. Rogowski, Philip Jochelson, Robert Mansbach
  • Low-dose doxepin formulations and methods of making and using the same
    Patent number: 11096920
    Abstract: The invention disclosed herein generally relates to low-dose oral doxepin pharmaceutical formulations and the use of these formulations to promote sleep.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: August 24, 2021
    Assignee: Currax Pharmaceuticals LLC
    Inventors: Luigi Schioppi, Brian Talmadge Dorsey, Michael Skinner, John Carter, Robert Mansbach, Philip Jochelson, Roberta L. Rogowski, Cara Baron Casseday, Meredith Perry, Bryan Knox
  • Methods of treating insomnia using a combination therapy of low-dose doxepin and zolpidem
    Patent number: 11013712
    Abstract: A composition comprising doxepin, or a pharmaceutically acceptable salt, or prodrug thereof, and a compound that enhances sleep onset, sleep maintenance or reduces early morning awakenings. These compositions are useful for treating multiple manifestations of insomnia.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: May 25, 2021
    Assignee: Currax Pharmaceuticals LLC
    Inventors: Philip Jochelson, Robert Mansbach, Michael Skinner, Neil B. Kavey
  • Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 11007168
    Abstract: The invention relates to use of the trans-(E) isomer or isomeric mixtures containing specified ratios of the trans-(E) and cis-(Z) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: May 18, 2021
    Assignees: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep
    Publication number: 20200345680
    Abstract: Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
    Type: Application
    Filed: May 18, 2020
    Publication date: November 5, 2020
    Applicants: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Roberta L. Rogowski, Susan E. Dubé, Philip Jochelson, Neil B. Kavey
  • Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 10758510
    Abstract: The invention relates to use of the cis-(Z) isomer or isomeric mixtures containing specified ratios of the cis-(Z) and trans-(E) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: September 1, 2020
    Assignees: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • Low-Dose Doxepin Formulations And Methods Of Making And Using The Same
    Publication number: 20200170991
    Abstract: The invention disclosed herein generally relates to low-dose oral doxepin pharmaceutical formulations and the use of these formulations to promote sleep.
    Type: Application
    Filed: February 3, 2020
    Publication date: June 4, 2020
    Applicant: Currax Pharmaceuticals LLC
    Inventors: Luigi Schioppi, Brian Talmadge Dorsey, Michael Skinner, John Carter, Robert Mansbach, Philip Jochelson, Roberta L. Rogowski, Cara Baron Casseday, Meredith Perry, Bryan Knox
  • Methods of using low-dose doxepin for the improvement of sleep
    Patent number: 10653662
    Abstract: Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: May 19, 2020
    Assignees: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Roberta L. Rogowski, Susan E. Dubé, Philip Jochelson, Neil B. Kavey
  • Methods of improving the pharmacokinetics of doxepin
    Patent number: 10653660
    Abstract: Methods of improving the pharmacokinetics of doxepin in a patient.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: May 19, 2020
    Assignee: Currax Pharmaceuticals LLC
    Inventors: Cara Baron Casseday, Elizabeth Ludington, Michael Skinner, Susan E. Dubé, Roberta L. Rogowski, Philip Jochelson, Robert Mansbach
  • Low-dose doxepin formulations and methods of making and using the same
    Patent number: 10548871
    Abstract: The invention disclosed herein generally relates to low-dose oral doxepin pharmaceutical formulations and the use of these formulations to promote sleep.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: February 4, 2020
    Assignee: Currax Pharmaceuticals LLC
    Inventors: Luigi Schioppi, Brian Talmadge Dorsey, Michael Skinner, John Carter, Robert Mansbach, Philip Jochelson, Roberta L. Rogowski, Cara Baron Casseday, Meredith Perry, Bryan Knox
  • Ultra low dose doxepin and methods of using the same to treat sleep disorders
    Patent number: 10507193
    Abstract: The invention relates to doxepin, pharmaceutically acceptable salts and prodrugs of doxepin; compositions containing the same, and the use of any of the aforementioned for the treatment of sleep disorders.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: December 17, 2019
    Assignees: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Philip Jochelson, Neil B. Kavey
  • Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 10493053
    Abstract: The invention relates to use of the trans-(E) isomer or isomeric mixtures containing specified ratios of the trans-(E) and cis-(Z) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: December 3, 2019
    Assignees: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey