Patents Assigned to Curtis, Inc.
  • Morphogenic protein-specific cell surface receptors and uses therefor
    Patent number: 6632618
    Abstract: Disclosed are (1) nucleic acid sequences, amino acid sequences, homologies, structural features and various other data characterizing a morphogen cell surface receptors particularly OP-1-binding cell surface receptors ALK-2, ALK-3, and ALK-6; (2) methods for producing receptor proteins, including fragments thereof, using recombinant DNA technology; (3) methods for identifying novel morphogen receptors and their encoding DNAS; (4) methods and compositions for identifying compounds capable of modulating endogenous morphogen receptor levels; and (5) methods and compositions for identifying morphogen receptor binding analogs useful in the design of morphogen agonists and antagonists for therapeutic, diagnostic and experimental uses.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 14, 2003
    Assignees: Curtis, Inc., Ludwig Institute for Cancer Research
    Inventors: Peter ten Dijke, Carl-Henrik Heldin, Kohei Miyazono, Kuber T. Sampath
  • Mediators of hedgehog signaling pathways, compositions and uses related thereto
    Patent number: 6545005
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: April 8, 2003
    Assignee: Curtis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Stephen Price, Lee D. Rubin