Abstract: Disclosed are (1) nucleic acid sequences, amino acid sequences, homologies, structural features and various other data characterizing a morphogen cell surface receptors particularly OP-1-binding cell surface receptors ALK-2, ALK-3, and ALK-6; (2) methods for producing receptor proteins, including fragments thereof, using recombinant DNA technology; (3) methods for identifying novel morphogen receptors and their encoding DNAS; (4) methods and compositions for identifying compounds capable of modulating endogenous morphogen receptor levels; and (5) methods and compositions for identifying morphogen receptor binding analogs useful in the design of morphogen agonists and antagonists for therapeutic, diagnostic and experimental uses.

Abstract: There is described a conditioning composition for conditioning, lightening and highlighting hair which comprises: (i) a peroxygen compound; and (ii) a conditioning agent, said composition having a pH of 5 or less. There is also described a method for conditioning lightening and highlighting hair which comprises treating said hair with a composition of the invention.

Abstract: The invention relates to an aqueous cleansing composition which comprises a combination of short and long chain anionic surfactants that provide mild cleansing and good lathering.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.

Abstract: A sprayhead for example for an aerosol or pumpspray container comprises a support, a fluid outlet mounted on the support, a passageway connected to the fluid outlet at a first end and connectable to a fluid source at a second end, the passageway being movable between a first non-operative position and a second position in which, in use, it is connected to a fluid source such that fluid can pass through the passageway to the fluid outlet, a member secured relative to the support, the member being movable between a non-operative position and a further position in which it allows the passageway to attain its second position, and a lock selectively operable to lock the member in its first position, thereby preventing the member from urging the passageway to its second position unless the lock is released.

Abstract: Cosmetic composition for use in personal care applications comprising a carrier and a polymeric biguanide, characterised in that the polymeric biguanide is in the form of its salt with an organic acid containing from 4 to 30 carbon atoms.

Abstract: The invention relates to aqueous hair care compositions including conditioners, shampoos, and mousses. The invention also relates to methods of treating hair, and more particularly to treating hair with aqueous hair care compositions which contain one or more elastomeric resinous materials. These materials when tested at the same concentration that could be incorporated into a product exhibit a G′ modulus between 1×102 and 1×105 dynes/cm2. Furthermore these resins when mixed with a hydrophilic or hydrophobic diluent at a ratio of 1:95 to 95:1% and this mixture then incorporated into an aqueous emulsion in the range of 0.1 to 10% have been demonstrated to deliver a consumer perceptible increase in hair body without sacrificing conditioning attributes.

Abstract: There is described a conditioning composition for conditioning, lightening and highlighting hair which comprises:

Abstract: Hair spray compositions containing a carboxylated polyurethane resin, and having a low volatile organic content, are disclosed. The compositions have a low viscosity, and can be applied as a pump spray or as an aerosol, to hold the hair and impart excellent hair set retention properties. The hair spray compositions can be used with a curling iron or a blow dryer to style the hair.

Abstract: The present invention is directed to an aqueous hair dressing or hair styling composition which comprises from about 1.5 to about 5.0 weight % polyquaternium 37/propylene glycol dicaprylate dicaprate and ppg-1 trideceth-6, also known as polyquat 37, and also known as Salcare 96. The compositions of the invention have good hair styling and manageability properties without tackiness.

Abstract: An aqueous conditioning shampoo composition comprising, in addition to water: i) at least one surfactant chosen from anionic, nonionic, zwitterionic or amphoteric surfactants or mixtures thereof: ii) emulsified particles of an insoluble, nonvolatile silicone; iii) a soluble cationic hair conditioning polymer having a cationic charge density of about +3.0 meq/gram or less, in which the emulsified particles of insoluble, nonvolatile silicone are incorporated into the shampoo composition as a preformed aqueous emulsion having an average silicone particle size in the emulsion and in the shampoo composition of from 2 to 30 microns.

Abstract: Hair spray compositions containing a carboxylated polyurethane resin, and having a low volatile organic content, are disclosed. The compositions have a low viscosity, and can be applied as a pump spray or as an aerosol, to hold the hair and impart excellent hair set retention properties. The hair spray compositions can be used with a curling iron or a blow dryer to style the hair.

Abstract: Hair styling gels containing a carboxylated polyurethane resin, a viscosity enhancer, and an optional second hair fixative resin, in an aqueous carrier, are disclosed. The styling gel compositions impart excellent hair styling, conditioning, and hair set retention properties to treated hair.

Abstract: The invention provides a washing composition for washing a surface to deposit thereon a solid active agent, the washing composition comprising an emulsion of silicone droplets, the silicone droplets comprising:

Abstract: The use of at least 0.5% by weight water as an additive in a hairspray composition for the purpose of inducing or enhancing autophobic behavior in the hairspray composition.

Abstract: Water-based, hair care products containing homogeneous terpolymers having both hair styling and conditioning properties is described.

Abstract: Foaming propellant compositions for use in hair mousse compositions described. These compositions contain hydrofluorocarbon 152A and a suitable hydrocarbon in a ratio of about 30 to 70; to about 50 to 50; more preferably about 40 to 60. These compositions comprise the hydrofluorocarbon 152A; and a hydrocarbon, selected from the group consisting of propane, isobutane, and n-butane in the above recited ratios. The above propellant mixture is about 4 to 9 wt. % of total foaming, hair care composition.

Abstract: Improved conditioning performance from a surfactant-based shampoo composition can be achieved by the inclusion in the shampoo composition of a specific combination of silicones, namely amino functionalised silicone and high viscosity non-amino functionalised silicone. Accordingly, the invention provides an aqueous shampoo composition comprising, in addition to water: i) at least one surfactant chosen from anionic, nonionic, zwitterionic or amphoteric surfactants or mixtures thereof; ii) an amino functionalised silicone; and iii) emulsified particles of an insoluble, non-amino functionalised silicone, in which the viscosity of the silicone itself is at least 500,000 cst, preferably at least 1,000,000 cst.

Abstract: The invention provides a washing composition for washing a surface to deposit thereon a solid active agent, the washing composition comprising an emulsion of silicone droplets, the silicone droplets comprising: (a) a continuous silicone phase, and; (b) a dispersed phase of solid particulate active agent. Preferably the solid active agent is a solid antimicrobial such as zinc pyridinethione.

Abstract: The present invention relates an opaque conditioner which comprises a monoalkyl quat from C16 to higher Carbon chain lengths (preferably C16 to C22) and a dialkyl quat from C16 to higher Carbon chain lengths (preferably C16 to C18). Also included is an amount of fatty alcohol necessary to opacify the conditioner. The monoalkyl quat is necessary in a ratio to the dialkyl quat of about not less than 2:1. The fatty alcohol is present in an amount from about 1% to about 4%.