Abstract: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
Type:
Grant
Filed:
December 4, 2001
Date of Patent:
July 19, 2005
Assignee:
CV Theapeutics, Inc.
Inventors:
Michael Campbell, Prabha N. Ibrahim, Jeff A. Zablocki, Richard Lawn