Patents Assigned to CVRx, Inc.
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Publication number: 20060111626Abstract: Electrode structures for implantation include an electrode, an elastic backing attached to the electrode, and a sequestered drug on the backing or the electrode which is released to control and/or limit the growth of scar tissue. The elastic backing includes a tissue contacting side which contacts a tissue structure, and an exposed side away from the tissue contacting side. The electrode structure can be used to activate baroreceptors, and the backing is elastic and can stretch and retract with the tissue structure, for example the carotid sinus. The electrode and the sequestered drug can be positioned on the tissue contacting side so the drug is released near the electrode. The backing can be made from an insulating material and limit diffusion of the drug toward the exposed side, permitting scar tissue to grow near the exposed side to maintain positioning of the electrode.Type: ApplicationFiled: December 29, 2005Publication date: May 25, 2006Applicant: CVRx, Inc.Inventors: Martin Rossing, Robert Kieval, Mary Cole
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Publication number: 20060074453Abstract: A method for treating heart failure in a patient involves activating a baroreflex system of the patient with at least one baroreflex activation device and resynchronizing the patient's heart with a cardiac resynchronization device. Activating the baroreflex system and resynchronizing the heart may be performed simultaneously or sequentially, in various embodiments. In some embodiments, one or more patient conditions are sensed, and such condition(s) may be used for setting and/or modifying the baroreflex activation and/or heart resynchronization. A device for treating heart failure includes a baroreflex activation member coupled with a cardiac resynchronization member. Some embodiments further include one or more sensors and a processor. In some embodiments, the device is fully implantable.Type: ApplicationFiled: October 4, 2004Publication date: April 6, 2006Applicant: CVRx, Inc.Inventors: Robert Kieval, Martin Rossing, Eric Irwin, John Brintnall
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Patent number: 6985774Abstract: Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, for example a baroreceptor in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption.Type: GrantFiled: September 26, 2001Date of Patent: January 10, 2006Assignee: CVRx, Inc.Inventors: Robert S. Kieval, Bruce J. Perrson, David J. Serdar, Peter T. Keith
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Publication number: 20060004420Abstract: A lockout connector arrangement for implantable medical devices having at least one port for receiving a non-cardiac lead connector selectively permits only certain electrical leads to be connected to the implantable medical device. A lead connector pin of a non-cardiac lead connector is specially designed to be larger than a DF-1 lead connector pin, but smaller than an IS-1 lead connector pin. A corresponding header of implantable pulse generator has a connector port for a non-cardiac lead with a proximal-most portion that is larger than the DF-1 lead connector pin, but smaller than the IS-1 lead connector pin; and otherwise generally consistent with the other dimensions of an ISO standard IS-1 pacemaker lead connector.Type: ApplicationFiled: June 27, 2005Publication date: January 5, 2006Applicant: CVRx, Inc.Inventors: Martin Rossing, Stephen Bolea, Aaron Hjelle, James Henry, Brad Pedersen
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Publication number: 20060004417Abstract: Devices, systems and methods provide baroreflex activation to prevent, or at least reduce the likelihood of occurrence of, cardiac arrhythmias. Various embodiments may additionally or alternatively promote recovery from arrhythmias. In one embodiment, a device for preventing or reducing the likelihood of occurrence of arrhythmias includes one or more baroreflex activation devices, one or more sensors coupled to the baroreflex activation device(s), and a processor for processing information from the sensor and activating and/or modulation the baroreflex activation device. Sensors, such as electrocardiogram devices, generally sense factors indicative of a potential, ensuing arrhythmia.Type: ApplicationFiled: June 27, 2005Publication date: January 5, 2006Applicant: CVRx, Inc.Inventors: Martin Rossing, Robert Kieval, Roy Martin, David Serdar, Eric Irwin
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Publication number: 20060004430Abstract: Connection structures on an extra-vascular electrode lead body improve strain relief and strengthen the transition region where electrical conductors carried by the lead body are joined to individual electrodes at the distal end of the lead. The electrodes include structure or mechanisms for externally securing the electrode assembly to a body part. A first connection structure is located on the lead body proximal the electrodes to anchor the lead body to a first anchor location in the body that generally moves in concert with the body part. A second connection structure is located on the lead body proximal to the first connection structure to anchor the lead body to a second anchor location that is at least partially independent of movement of the body part. The first and second anchor location are offset by a distance that is less than a distance between the first and second connection structures to provide strain relief for the electrodes.Type: ApplicationFiled: June 27, 2005Publication date: January 5, 2006Applicant: CVRx, Inc.Inventors: Martin Rossing, Stephen Bolea, David Mayer, Aaron Hjelle, Tom Crowley, Eric Irwin
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Publication number: 20050251212Abstract: Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, for example a baroreceptor in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption.Type: ApplicationFiled: July 20, 2005Publication date: November 10, 2005Applicant: CVRx, Inc.Inventors: Robert Kieval, Bruce Persson, David Serdar, Peter Keith
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Publication number: 20050096710Abstract: Devices, systems and methods are described for controlling, preventing and/or treating epileptic seizures by activating baroreceptors. By selectively and controllably activating baroreceptors, the present invention reduces seizure activity, thereby minimizing the effects of epilepsy. A baroreceptor activation device is positioned near a baroreceptor on the patient's arterial or venous vasculature, for example in the carotid sinus, aortic arch, inferior vena cava, or the like. One or more optional sensors, such as EEG sensors, detect neurological activity to help determine when to activate baroreceptors to reduce or prevent seizures.Type: ApplicationFiled: September 21, 2004Publication date: May 5, 2005Applicant: CVRx, Inc.Inventor: Robert Kieval
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Patent number: 6850801Abstract: Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably in the carotid sinus. A mapping method permits the baroreceptor activation device to be precisely located to maximize therapeutic efficacy.Type: GrantFiled: September 26, 2001Date of Patent: February 1, 2005Assignee: CVRx, Inc.Inventors: Robert S. Kieval, Bruce J. Persson, David J. Serdar, Peter T. Keith
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Publication number: 20040254616Abstract: Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval, establishing a plurality of dose intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of at least some dose intervals. Another method comprises establishing a series of therapy interval portions, during at least some therapy intervals, establishing a plurality of burst intervals (perhaps having durations commensurate with an interval between heartbeats), and generating an electrical output signal.Type: ApplicationFiled: April 5, 2004Publication date: December 16, 2004Applicant: CVRx, Inc.Inventors: Martin A. Rossing, Robert S. Kieval, David J. Serdar, Bruce J. Persson
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Publication number: 20040019364Abstract: Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize RF-coupled or other electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.Type: ApplicationFiled: March 27, 2003Publication date: January 29, 2004Applicant: CVRX, Inc.Inventors: Robert S. Kieval, Bruce J. Persson, David J. Serdar, Peter T. Keith, Martin A. Rossing
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Publication number: 20040010303Abstract: Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.Type: ApplicationFiled: March 27, 2003Publication date: January 15, 2004Applicant: CVRx, Inc.Inventors: Stephen L. Bolea, Robert S. Kieval, Bruce J. Persson, David J. Serdar, Peter T. Keith, Eric D. Irwin, Martin A. Rossing
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Publication number: 20030199806Abstract: Devices, systems and methods by which the real or apparent renovascular perfusion and intrarenal pressure may be selectively and controllably increased. By selectively and controllably increasing renovascular perfusion and interstitial hydrostatic pressure when the heart is unable to pump sufficient blood or when renal perfusion is suboptimal, the present invention reduces or reverses neurohormonal activation and fluid retention, and thereby minimizes their deleterious effects on the heart, vasculature, kidneys and other body systems.Type: ApplicationFiled: June 2, 2003Publication date: October 23, 2003Applicant: CVRx, Inc.Inventor: Robert S. Kieval
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Patent number: 6616624Abstract: Devices, systems and methods by which the real or apparent renovascular perfusion and intrarenal pressure may be selectively and controllably increased. By selectively and controllably increasing renovascular perfusion and interstitial hydrostatic pressure when the heart is unable to pump sufficient blood or when renal perfusion is suboptimal, the present invention reduces or reverses neurohormonal activation and fluid retention, and thereby minimizes their deleterious effects on the heart, vasculature, kidneys and other body systems.Type: GrantFiled: October 30, 2000Date of Patent: September 9, 2003Assignee: CVRX, Inc.Inventor: Robert S. Kieval
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Patent number: 6522926Abstract: Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. By selectively and controllably activating baroreceptors, the present invention reduces excessive blood pressure, sympathetic nervous system activity and neurohormonal activity, thereby minimizing their deleterious effects on the heart, vasculature and other organs and tissues. A baroreceptor activation device is positioned near a baroreceptor, preferably in the carotid sinus and/or the aortic arch. The baroreceptor activation device may comprise a wide variety of devices which utilize mechanical, electrical, thermal, chemical or biological means to activate the baroreceptor. A control system may be used to generate a control signal to modulate the baroreceptor activation device.Type: GrantFiled: September 27, 2000Date of Patent: February 18, 2003Assignee: CVRx, Inc.Inventors: Robert S. Kieval, Peter T. Keith, Matthew M. Burns, Thomas R. Hektner, Gina L. Hansen