Patents Assigned to Cyano Biotech GmbH
  • Modified microcystins and nodularins
    Patent number: 11512114
    Abstract: A compound includes cytotoxic agents such as microcystin and nodularin. More specifically, a modified microcystin and/or nodularin compound contains one or more modified substrates, wherein one or more modified substrates include an anchor group directly accessible or transformable for use in conjugation chemistry (incl. click chemistry), for the attachment of a targeting moiety. This compound is useful for cancer treatment.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: November 29, 2022
    Assignee: Cyano Biotech GmbH
    Inventors: Heike Enke, Wolfram Lorenzen, Stefan Jahns, Dan Enke, Timo Niedermeyer, Julia Moschny
  • Method for modifying microcystins and nodularins
    Patent number: 11124818
    Abstract: A method is used for producing a modified non-ribosomal peptide, e.g. a modified microcystin and/or modified nodularin (together CA), including the steps of: a) growing a modified non-ribosomal peptide producing cyanobacteria strain in a culture media, h) adding one or more modified substrates, preferably modified amino acids to said culture, and c) inoculating the non-ribosomal peptide, producing strain the presence of said modified substrates. The thus modified non-ribosomal peptide may be used for the therapy of various diseases.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: September 21, 2021
    Assignee: Cyano Biotech GmbH
    Inventors: Heike Enke, Wolfram Lorenzen, Stefan Jahns, Dan Enke, Timo Niedermeyer, Julia Moschny
  • METHOD FOR MODIFYING MICROCYSTINS AND NODULARINS
    Publication number: 20200377922
    Abstract: A method is used for producing a modified non-ribosomal peptide, e.g. a modified microcystin and/or modified nodularin (together CA), including the steps of a) growing a modified non-ribosomal peptide producing cyanobacteria strain in a culture media, b) adding one or more modified substrates, preferably modified amino acids to said culture, and c) inoculating the non-ribosomal peptide, producing strain the presence of said modified substrates. The thus modified non-ribosomal peptide may be used for the therapy of various diseases.
    Type: Application
    Filed: May 9, 2018
    Publication date: December 3, 2020
    Applicant: Cyano Biotech GmbH
    Inventors: Heike Enke, Wolfram Lorenzen, Stefan Jahns, Dan Enke, Timo Niedermeyer, Julia Moschny
  • MODIFIED MICROCYSTINS AND NODULARINS
    Publication number: 20200087348
    Abstract: A compound includes cytotoxic agents such as microcystin and nodularin. More specifically, a modified microcystin and/or nodularin compound contains one or more modified substrates, wherein one or more modified substrates include an anchor group directly accessible or transformable for use in conjugation chemistry (incl. click chemistry), for the attachment of a targeting moiety. This compound is useful for cancer treatment.
    Type: Application
    Filed: May 9, 2018
    Publication date: March 19, 2020
    Applicant: Cyano Biotech GmbH
    Inventors: Heike Enke, Wolfram Lorenzen, Stefan Jahns, Dan Enke, Timo Niedermeyer, Julia Moschny
  • MICROGININ PRODUCING PROTEINS AND NUCLEIC ACIDS ENCODING A MICROGININ GENE CLUSTER AS WELL AS METHODS FOR CREATING NOVEL MICROGININS
    Publication number: 20110034680
    Abstract: The invention provides for nucleic acid molecules enabling the synthesis of microginin and microginin analogues. The invention also provides for methods for identifying microginins as well creating microginins which may not be found in nature.
    Type: Application
    Filed: October 22, 2010
    Publication date: February 10, 2011
    Applicants: CYANO BIOTECH GMBH, HUMBOLDT-UNIVERSITAET ZU BERLIN
    Inventor: Dan KRAMER
  • Microginin producing proteins and nucleic acids encoding a microginin gene cluster as well as methods for creating novel microginins
    Patent number: 7846686
    Abstract: The invention provides for nucleic acid molecules enabling the synthesis of microginin and microginin analogues. The invention also provides for methods for identifying microginins as well creating microginins which may not be found in nature.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: December 7, 2010
    Assignees: Cyano Biotech GmbH, Humboldt-Universitaet zu Berlin
    Inventor: Dan Kramer
  • MICROGININ PRODUCING PROTEINS AND NUCLEIC ACIDS ENCODING A MICROGININ GENE CLUSTER AS WELL AS METHODS FOR CREATING NOVEL MICROGININS
    Publication number: 20090220962
    Abstract: The invention provides for nucleic acid molecules enabling the synthesis of microginin and microginin analogues. The invention also provides for methods for identifying microginins as well creating microginins which may not be found in nature.
    Type: Application
    Filed: December 1, 2006
    Publication date: September 3, 2009
    Applicants: CYANO BIOTECH GmBH, HUMBOLDT-UNIVERSITAET ZU BERLIN
    Inventor: Dan Kramer