Patents Assigned to CyberLogic, Inc.
  • Patent number: 9615814
    Abstract: An invention is disclosed for locating a region of interest in the calcaneus. A pair of ultrasound transducers are positioned on the medial and lateral sides of the heel, respectively. The positioning is based on a size of a portion of the body of a subject upon whom the ultrasound assessment of the calcaneus is to be made. In a presently preferred embodiment, the length of the foot from the back to the head of the first metatarsal is used in conjunction with a proportionality constant and an angle, to position the pair of transducers. The positioning so obtained facilitates (i) reproducible measurements and (ii) comparisons of the results obtained in one person with another, because relatively analogous portions of the highly heterogeneous calcanei are assessed in both. In an alternative embodiment, a single transducer is positioned similarly on the heel, operating in pulse-echo mode.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: April 11, 2017
    Assignee: CyberLogic, Inc.
    Inventors: Gangming Luo, Jonathan J. Kaufman
  • Patent number: 9532761
    Abstract: A method and system for quantitatively evaluating bone fracture risk in a living being are provided that generate a value for an index indicative of a degree of bone fracture risk. In one embodiment, the method includes the step of acquiring values for a height H, a weight W, and a bone mineral density BMD of the living being. The method further includes the step of calculating a quantitative bone fracture risk index QI associated with the living being in accordance with the formula QI=H?*W?/BMD? where ?, ?, and ? are constants selected based on previously obtained data indicative of bone fracture risk.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: January 3, 2017
    Assignee: CyberLogic, Inc.
    Inventors: Gangming Luo, Jonathan J. Kaufman
  • Patent number: 9039616
    Abstract: An invention is disclosed for locating a region of interest (ROI) in the radius. A method and apparatus are disclosed that use a pair of ultrasound transducers for ultrasound assessment of various properties of bone. The invention includes positioning the transducers on the anterior-posterior (dorsal and ventral) sides of a forearm of an individual. The positioning is based on the forearm length, and a selected percentage of this length at which the ROI is desired. In a presently preferred embodiment of the invention, the ROI is defined as the ?rd location. An arm is placed in an ultrasound fixture which has a first surface, a second surface with a raised portion against which the ulna styloid process is placed, and a third surface on which the elbow is placed. The distance between the raised portion of the second surface and the centerlines of the pair of ultrasound transducers is adjustable.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: May 26, 2015
    Assignee: CyberLogic, Inc.
    Inventors: Gangming Luo, Jonathan J. Kaufman
  • Patent number: 8202219
    Abstract: A method for the assessment of various properties of bone is provided. The method includes applying a pair of ultrasound transducers to skin on opposite sides of the bone and generating an ultrasound signal and directing the signal through both the bone to obtain a bone output signal. The method further includes establishing a set of parameters associated with the bone output signal and then further processing the parameters in order to obtain the desired bone property. Two novel parameters are also disclosed, namely the net time delay (NTD) and mean time duration (MTD) parameters. An apparatus for the assessment of various properties of bone is also provided. The apparatus includes a pair of ultrasound transducers which may be single-element transducers or array transducers in any combination. The apparatus further includes various computer hardware components and computer software for generating and directing the ultrasound signal, establishing the parameter set and performing the processing.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: June 19, 2012
    Assignee: CyberLogic, Inc.
    Inventors: Gangming Luo, Robert S. Siffert, William A. Johnson, Ronald L. Altman, Jonathan J. Kaufman
  • Publication number: 20120010509
    Abstract: A method and apparatus for non-invasive and quantitative assessment of the status of a lumbar vertebral body in a living being for at least one of several quantities (e.g., bone-mineral density, bone mass, etc.) is provided. The method includes the steps of acoustically coupling first and second transducers to nearby skin on opposite sides of a torso of the living being and generating an ultrasound signal and directing the ultrasound signal from the first transducer to the second transducer through the torso. At least a portion of the ultrasound signal passes through the lumbar vertebral body and the second transducer generates an output signal responsive to receipt of the ultrasound signal. The method further includes the step of processing the output signal to obtain an estimate of the at least one quantity.
    Type: Application
    Filed: July 7, 2011
    Publication date: January 12, 2012
    Applicant: CyberLogic, Inc.
    Inventors: Jonathan J. Kaufman, Gangming Luo
  • Publication number: 20110313289
    Abstract: An invention is disclosed for locating a region of interest (ROI) in the radius. A method and apparatus are disclosed that use a pair of ultrasound transducers for ultrasound assessment of various properties of bone. The invention includes positioning the transducers on the anterior-posterior (dorsal and ventral) sides of a forearm of an individual. The positioning is based on the forearm length, and a selected percentage of this length at which the ROI is desired. In a presently preferred embodiment of the invention, the ROI is defined as the ?rd location. An arm is placed in an ultrasound fixture which has a first surface, a second surface with a raised portion against which the ulna styloid process is placed, and a third surface on which the elbow is placed. The distance between the raised portion of the second surface and the centerlines of the pair of ultrasound transducers is adjustable.
    Type: Application
    Filed: February 11, 2010
    Publication date: December 22, 2011
    Applicant: CyberLogic, Inc.
    Inventors: Gangming Luo, Jonathan J. Kaufman
  • Publication number: 20110125015
    Abstract: An invention is disclosed for locating a region of interest in the calcaneus. A pair of ultrasound transducers are positioned on the medial and lateral sides of the heel, respectively. The positioning is based on a size of a portion of the body of a subject upon whom the ultrasound assessment of the calcaneus is to be made. In a presently preferred embodiment, the length of the foot from the back to the head of the first metatarsal is used in conjunction with a proportionality constant and an angle, to position the pair of transducers. The positioning so obtained facilitates (i) reproducible measurements and (ii) comparisons of the results obtained in one person with another, because relatively analogous portions of the highly heterogeneous calcanei are assessed in both. In an alternative embodiment, a single transducer is positioned similarly on the heel, operating in pulse-echo mode.
    Type: Application
    Filed: January 27, 2011
    Publication date: May 26, 2011
    Applicant: Cyberlogic, Inc.
    Inventors: Gangming Luo, Jonathan J. Kaufman
  • Patent number: 7901356
    Abstract: An invention is disclosed for locating a region of interest in the calcaneus. A pair of ultrasound transducers are positioned on the medial and lateral sides of the heel, respectively. The positioning is based on a size of a portion of the body of a subject upon whom the ultrasound assessment of the calcaneus is to be made. In a presently preferred embodiment, the length of the foot from the back to the head of the first metatarsal is used in conjunction with a proportionality constant and an angle, to position the pair of transducers. The positioning so obtained facilitates (i) reproducible measurements and (ii) comparisons of the results obtained in one person with another, because relatively analogous portions of the highly heterogeneous calcanei are assessed in both. In an alternative embodiment, a single transducer is positioned similarly on the heel, operating in pulse-echo mode.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: March 8, 2011
    Assignee: Cyberlogic, Inc.
    Inventors: Gangming Luo, Jonathan J. Kaufman
  • Patent number: 7862510
    Abstract: An apparatus and method for the assessment of various properties of bone is provided. A pair of ultrasound transducers are applied to skin on opposite sides of a bony member. The transducers may be single-element or array transducers. An ultrasound signal is generated and directed through the bony member to obtain a bone output signal. A set of parameters associated with the bone output signal is established and processed to obtain the desired bone property including two net time delay (NTD) parameters indicative of differences in transit time for signals taking different paths through bone and soft tissue. Also disclosed is a novel means for acoustically coupling the transducers to skin, as well as a means for establishing bone mineralization through use of both ultrasound and x-ray measurements.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: January 4, 2011
    Assignee: Cyberlogic, Inc.
    Inventors: Gangming Luo, Jonathan J. Kaufman
  • Patent number: 6570955
    Abstract: Non-invasive quantitative plain radiographic evaluation of bone in a bony locale of a body is performed by subjecting the bony locale to a broadband collimated x-ray beam having energy in the range of about 20 keV to 150 keV. Alongside the bony locale is a composite phantom. The composite phantom is comprised of at least two materials, superimposed on one another. An energy-selective multiple-film detector cassette containing at least two films is placed under the body and composite phantom to receive the transmitted x-ray beam. The films in the cassette are developed and digitally scanned to produce sets of composite phantom data and sets of bone data. The data sets are then numerically processed using interpolation whereby to generate the indicated estimate of bone status, namely, bone-mineral density. In an alternative embodiment, an independent measurement is made of the total tissue thickness, and the bone status is determined using interpolation based only on a single film.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: May 27, 2003
    Assignee: Cyberlogic, Inc.
    Inventors: Robert S. Siffert, Jonathan J. Kaufman
  • Patent number: 6329963
    Abstract: In a presently preferred embodiment of the invention, a three-dimensional scene is reproduced on a specialized light display which offers full multiviewpoint capability and auto-stereoscopic views. The displayed image is produced using a set of M two-dimensional images of the scene collected at a set of distinct spatial locations. These M two-dimensional images are processed through a specialized mathematical encoding scheme to obtain a set of N×K display-excitation electrical-input signals, where K is the number of pixels in the display, and N≦M is the number of individual light-radiating elements within one pixel. The display is thus comprised of a total of N×K light-radiating elements. Each of the K pixels is adapted for control of their associated radiance patterns. The display is connected for response to the set of N×K display-excitation electrical-input signals.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: December 11, 2001
    Assignee: CyberLogic, Inc.
    Inventors: Alessandro Chiabrera, Bruno Bianco, Jonathan J. Kaufman
  • Patent number: 6324252
    Abstract: Non-invasive quantitative plain radiographic evaluation of bone in a bony locale of a body is performed by subjecting the bony locale to a broadband collimated x-ray beam having energy in the range of about 20 keV to 150 keV. Alongside the bony locale is a composite phantom. The composite phantom is comprised of at least two materials, superimposed on one another. An energy-selective multiple-film detector cassette containing at least two films is placed under the body and composite phantom to receive the transmitted x-ray beam. The films in the cassette are developed and digitally scanned to produce sets of composite phantom data and sets of bone data. The data sets are then numerically processed using interpolation whereby to generate the indicated estimate of bone status, namely, bone-mineral density. In an alternative embodiment, an independent measurement is made of the total tissue thickness, and the bone status is determined using interpolation based only on a single film.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: November 27, 2001
    Assignee: CyberLogic, Inc.
    Inventors: Robert S. Siffert, Jonathan J. Kaufman
  • Publication number: 20010004394
    Abstract: Non-invasive quantitative plain radiographic evaluation of bone in a bony locale of a body is performed by subjecting the bony locale to a broadband collimated x-ray beam having energy in the range of about 20 keV to 150 keV. Alongside the bony locale is a composite phantom. The composite phantom is comprised of at least two materials, superimposed on one another. An energy-selective multiple-film detector cassette containing at least two films is placed under the body and composite phantom to receive the transmitted x-ray beam. The films in the cassette are developed and digitally scanned to produce sets of composite phantom data and sets of bone data. The data sets are then numerically processed using interpolation whereby to generate the indicated estimate of bone status, namely, bone-mineral density. In an alternative embodiment, an independent measurement is made of the total tissue thickness, and the bone status is determined using interpolation based only on a single film.
    Type: Application
    Filed: November 30, 2000
    Publication date: June 21, 2001
    Applicant: CyberLogic, Inc.
    Inventors: Robert S. Siffert, Jonathan J. Kaufman
  • Publication number: 20010002925
    Abstract: Non-invasive quantitative plain radiographic evaluation of bone in a bony locale of a body is performed by subjecting the bony locale to a broadband collimated x-ray beam having energy in the range of about 20 keV to 150 keV. Alongside the bony locale is a composite phantom. The composite phantom is comprised of at least two materials, superimposed on one another. An energy-selective multiple-film detector cassette containing at least two films is placed under the body and composite phantom to receive the transmitted x-ray beam. The films in the cassette are developed and digitally scanned to produce sets of composite phantom data and sets of bone data. The data sets are then numerically processed using interpolation whereby to generate the indicated estimate of bone status, namely, bone-mineral density. In an alternative embodiment, an independent measurement is made of the total tissue thickness, and the bone status is determined using interpolation based only on a single film.
    Type: Application
    Filed: November 30, 2000
    Publication date: June 7, 2001
    Applicant: CyberLogic, Inc.,
    Inventors: Robert S. Siffert, Jonathan J. Kaufman
  • Patent number: 6173038
    Abstract: Non-invasive quantitative plain radiographic evaluation of bone in a bony locale of a body is performed by subjecting the bony locale to a broadband collimated x-ray beam having energy in the range of about 20 keV to 150 keV. Alongside the bony locale is a composite phantom. The composite phantom is comprised of at least two materials, superimposed on one another. An energy-selective multiple-film detector cassette containing at least two films is placed under the body and composite phantom to receive the transmitted x-ray beam. The films in the cassette are developed and digitally scanned to produce sets of composite phantom data and sets of bone data. The data sets are then numerically processed using interpolation whereby to generate the indicated estimate of bone status, namely, bone-mineral density. In an alternative embodiment, an independent measurement is made of the total tissue thickness, and the bone status is determined using interpolation based only on a single film.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: January 9, 2001
    Assignee: CyberLogic, Inc.
    Inventors: Robert S. Siffert, Jonathan J. Kaufman
  • Patent number: 6064716
    Abstract: Non-invasive quantitative plain radiographic evaluation of bone in a bony locale of a body is performed by subjecting the bony locale to a broadband collimated x-ray beam having energy in the range of about 20 keV to 150 keV. Alongside the bony locale is a material phantom. An energy-selective multiple-film detector cassette containing at least two films is placed under the body and material phantom to receive the transmitted x-ray beam. The films in the cassette are developed and digitally scanned to produce sets of material phantom data and sets of bone data. The data sets are then processed with a feedforward neural network whereby to generate the indicated estimate of bone status, namely, bone-mineral density. In an alternative embodiment, an independent measurement is made of the total tissue thickness, and input to the neural network to achieve higher accuracy and precision.
    Type: Grant
    Filed: March 2, 1999
    Date of Patent: May 16, 2000
    Assignee: CyberLogic, Inc.
    Inventors: Robert S. Siffert, Alessandro Chiabrera, Jonathan J. Kaufman
  • Patent number: 5917877
    Abstract: Non-invasive quantitative plain radiographic evaluation of bone in a bony locale of a body is performed by subjecting the bony locale to a broadband collimated x-ray beam having energy in the range of about 20 keV to 150 keV. Alongside the bony locale is a multiple-material phantom containing at least two distinct materials. An energy-selective multiple-film detector cassette containing at least two films is placed under the body and multiple-material phantom to receive the transmitted x-ray beam. The films in the cassette are developed and digitally scanned to produce sets of multiple-material phantom data and sets of bone data. The data sets are then processed with a nonlinear algorithm whereby to generate the indicated estimate of bone status, namely, bone-mineral density.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: June 29, 1999
    Assignee: Cyberlogic, Inc.
    Inventors: Alessandro Chiabrera, Robert S. Siffert, Jonathan J. Kaufman
  • Patent number: 5782763
    Abstract: Non-invasive quantitative in-vivo electromagnetic evaluation of bone is performed by subjecting bone to an electrical excitation wave-form supplied to a pair of electrodes on opposite sides of a bony member, and involving a repetitive finite duration signal consisting of plural frequencies that are in the range 0 Hz-200 MHz. Signal-processing of a bone-current response signal and a bone-voltage response signal is operative to sequentially average the most recently received given number of successive bone-current and bone-voltage response signals to obtain an averaged per-pulse bone-current signal and an averaged per-pulse bone-voltage signal, and to produce their associated Fourier transforms. These Fourier transforms are further processed to obtain the frequency-dependent bone-admittance function.
    Type: Grant
    Filed: July 1, 1997
    Date of Patent: July 21, 1998
    Assignee: Cyberlogic Inc.
    Inventors: Bruno Bianco, Alessandro Chiabrera, Jonathan J. Kaufman