Abstract: A capillary dispenser includes at least one plunger-cylinder unit having a cylinder module and a plunger module disposed together on an axis. The cylinder module has an inner cylinder that is pneumatically connected to at least one capillary. The plunger module includes a hollow plunger that is closable on one side and is movable in the inner cylinder along the axis between an upper end position and a lower end position of the plunger module.

Abstract: A cold box having a cooling receptacle filled with a dry protective gas in which is accommodated a rack loaded with tube-shaped vessels. The cooling receptacle is covered by a displaceable lid which is associated with a lid part and which is preferably formed by an outer lid and a rotatable inner lid integrated in the outer lid so that the cooling receptacle is completely covered in every position of the lid. At least one of the through-holes provided in the inner lid can be arranged over a respective tube-shaped vessel by a coordinated displacement of the outer lid and rotation of the inner lid so that the tube-shaped vessel located under the through-hole in alignment therewith can be filled with a sample through the through-hole by means of a commercially available pipette tip/dispensing needle of an automated pipetting device.

Abstract: A suction device for a matrix array of pipette tips includes a tray configured to hold a liquid dispensed by the pipette tips. The tray includes an open-pore tray bottom. A suction tray cooperates with the open-pore tray bottom so as to form a vacuum chamber with the open-pore tray bottom forming a constituent of the vacuum chamber. A suction element is indirectly connected to the tray via the vacuum chamber so as to be configured to actively draw liquid over an entire surface into the vacuum chamber by suction via the tray bottom.

Abstract: A device for loading, storing and providing objects having standardized dimensions includes a storage unit with a carrier plate and four stackers. Each stacker includes a bottom surface disposed on top of the carrier plate. The stackers are configured to store objects stacked perpendicular to the carrier plate. The stackers are disposed symmetrically centered around a rotation axis that is perpendicular to the carrier plate and offset with respect to each other by an angle of 90°. A substructure is disposed underneath the carrier plate. An unloading device is configured to unload a selected object from a first of the stackers that is disposed in a transfer position. The storage unit is rotatable around the rotation axis so as to enable movement of each of the stackers into the transfer position.

Abstract: A capillary dispenser includes at least one plunger-cylinder unit having a cylinder module and a plunger module disposed together on an axis. The cylinder module has an inner cylinder that is pneumatically connected to at least one capillary. The plunger module includes a hollow plunger that is closable on one side and is movable in the inner cylinder along the axis between an upper end position and a lower end position of the plunger module.

Abstract: A pipetting apparatus including a pipetting head with a plurality of pipetting channels disposed in an arrangement pattern. Each pipetting channel includes a plunger and a cylinder. The plurality of pipetting channels includes at least two groups of pipetting channels with different diameters including a group of larger pipetting channels and a group of smaller pipetting channels. Each of the at least two groups of pipetting channels is disposed in an arrangement pattern in the pipetting head. Larger pipette tips communicate with the group of larger pipetting channels or smaller pipette tips communicate with the group of smaller pipetting channels.

Abstract: The invention relates to a sealing assembly for a metering device, in particular a multi-channel metering device. The sealing assembly serves to seal pipette tips with respect to the metering device. A multi-channel metering device comprises a multiplicity of openings arranged in one plane. A sealing plate with holes in the grid of the openings abuts this plane. Each pipette tip is provided with an annular collar which has an abutting face and is pressed against the sealing plate by force closure so as to enclose one hole.

Abstract: A device for loading, storing and providing objects having standardized dimensions includes a storage unit with a carrier plate and four stackers. Each stacker includes a bottom surface disposed on top of the carrier plate. The stackers are configured to store objects stacked perpendicular to the carrier plate. The stackers are disposed symmetrically centered around a rotation axis that is perpendicular to the carrier plate and offset with respect to each other by an angle of 90°. A substructure is disposed underneath the carrier plate. An unloading device is configured to unload a selected object from a first of the stackers that is disposed in a transfer position. The storage unit is rotatable around the rotation axis so as to enable movement of each of the stackers into the transfer position.

Abstract: A pipetting device, having a base plate, an elastic sealing plate that covers the outside of the base plate, and a plurality of pipetting channels arranged in a predetermined grid extending through the base plate and the sealing plate. A magazine is loaded in the same grid with the pipette tips, each pipette tip having a shoulder. The magazine is arranged in a magazine holder indirectly frictionally connected via the shoulders and the sealing plate with the base plate, and a drive motor, indirectly connected to the eccentric shafts of two identical eccentric drives that are permanently mounted on the support on the base plate. Each drive has an eccentric pin that is offset by a distance with respect to the axis of the eccentric shaft, and one T-shaped gravitational pendulum is suspended from each of the eccentric pins. The magazine holder is formed by a U-shaped magazine frame with a bearing surface on the inside.

Abstract: An integral molded part of a plastic material for the analysis and preparation of substances, having at least one surface region and an interior region, wherein said at least one surface region is an open-pore three-dimensional network.

Abstract: An arrangement and process for calibrating and/or equilibrating single-channel and multi-channel liquid handling devices, wherein a dispensing volume of a liquid is dispensed via the dispensing channels of a liquid handling device into a measurement chamber of a measurement chamber carrier, each measurement chamber being associated with a dispensing channel, and the individual measurement chambers are hermetically sealed successively relative to the environment and are connected to a pressure chamber under an operating pressure so that an equilibrium pressure occurs that is relevant to the respective dispensing volume.

Abstract: The invention concerns an automatic pipetting unit with a replaceable pipetting head. The pipetting head includes two head rails located on opposite sides. The pipetting unit also has two horizontal guide channels located in the interior of the pipetting unit for supporting the two head rails. Two frame-mounted, double-sided slider crank mechanisms are vertically arranged in the pipetting unit. Each double-sided slider crank mechanism includes two crank mechanisms each connected to a common articulated thrust joint by a thrust couple. The horizontal guide channels are formed in the articulated thrust joint and the crank mechanisms are connected indirectly to a head cover of the pipetting unit, so that with the opening and closing motion of the head cover the two slider crank mechanisms are moved between two end positions so that the pipetting head can be moved vertically between a lower end working position and an upper end replacement position.

Abstract: Procedure for equilibration of the delivery volumes of a multi-channel metering apparatus with an arrangement of independently controlled dispensing channels 1.1-1.n, delivering individual volumes of dispensing fluid to cavities 3.1.1-3.n.n, where measured values relevant to the individual delivery volumes are measured for the same control value and from which an adjustment value is specified with a tolerance band and the control value is adjusted for dispensing channels 1.1-1.n, the measured values of which lie outside the tolerance band. The invention also applies to an apparatus for implementing the procedure.

Abstract: An automatic pipetting and analyzing device for the preparation and analysis of samples in the wells of a microtitration plate has a work platform on which positioning areas for auxiliary devices and a movement area for the sample plate are provided, a passive mechanical table without its own drive unit, the sample plate lying within the inner passive slide of the passive mechanical table, and an active mechanical table which is arranged above the passive mechanical table and by which a pipetting head can be moved in X-Y direction over the work platform in order to extract, transport and dispense liquids by at least one pipetting channel and in order to displace the sample plate by a coupling connection with the inner passive slide, for example, to place the sample plate in an incubator or to position it with the individual wells in an analysis device.

Abstract: A method for characterizing highly parallelized liquid handling technology using microplates and test kit for carrying out the method. Possibilities for characterizing a multi-channel or many-channel handling technology are known in principle. However, especially with regard to more highly parallelized devices and very small volumes, particularly under conditions corresponding to the actual application conditions, these possibilities were relatively expensive and presented problems especially with respect to the accuracy of evaluation and with respect to correctness and precision. The present method enables a more economical and very exact characterization for applications of this kind.

Abstract: Multi-channel metering apparatus with automatic calibration, where the individual dispensing channels 1, the micro-valves 4 of which are connected with the outlets of a distributor 8, 13 or 15 whose inlet is filled with fluid by a vessel 9, 14 or 17 thus connected, are able to be calibrated in relation to each other in that between the vessel 9, 14 or 17 and the inlet of the distributor 8, 13 or 15 a flow sensor 10 is arranged which for calibration during delivery of the fluid via a respective nozzle 2 of a respective dispensing channel 1 records the flow and generates signals which are respectively assigned to a defined opening time of a micro-valve 4 and a specific dispensing channel 1 and thus stored allows for individual control of the micro-valves 4 in order to equalize the tolerances of the dispensing channels 1.

Abstract: The invention is directed to a device for dispensing and observing the luminescence of individual specimens in multi-specimen arrangements, particularly for the examination of biological, chemical or cytobiological assays with high specimen throughput. It is the object of the invention to find a novel possibility for dispensing in multi-specimen arrangements (microplates) and for observing the luminescence of the individual specimens, particularly for examining biological assays with high specimen throughput, which permits an immediate observation of the course of luminescence while dispensing proceeds at the same time without being limited to a determined type of microplate.

Abstract: An automatic tip changer for an automatic multichannel pipettor comprises a plurality of pipettes arranged in a pipetting head. Each of the pipettes arranged in the pipetting head is directly connected to a tip. A magazine which is outfitted with tips and lying in a magazine frame is pressed against the pipetting head. A supply carousel is provided for storing a plurality of stacking boxes in which magazines outfitted with tips are deposited. A lifting group which is arranged in a stationary manner relative to the supply carousel and the magazines are positioned successively in a mounting plane which is determined by the position of the magazine frame. A sliding group is included which is arranged in a stationary manner relative to the lifting group and by which the magazines are displaceable back and forth successively between the stacking box and the magazine frame.

Abstract: Device for automatically implementing the SPE method, with a two-dimensional needle arrangement which is suitable for removing substances from different two-dimensional specimen vessel arrangements and dispensing them under pressure into a two-dimensional cartridge arrangement.

Abstract: The invention is directed to a device for optical analytic measurement in a multisample carrier, particularly for measuring fluorescence or bioluminescence.