Abstract: The present invention relates to oral pharmaceutical compositions comprising nitisinone, or a pharmaceutically acceptable salt thereof, their use in the treatment of tyrosinemia, such as Hereditary Tyrosinemia type-1 (HT-1), or alkaptonuria. The compositions have improved stability characteristics. The invention also relates to processes for producing nitisinone.
Type:
Grant
Filed:
January 5, 2015
Date of Patent:
June 25, 2019
Assignee:
CYCLE PHARMACEUTICALS LTD
Inventors:
James Harrison, Stephen Fuller, Tobias Josef Brown