Patents Assigned to Cyclex Co., Ltd.
  • Kit for determining the acetylation level of a peptide based on sensitivity of the peptide to peptidase
    Patent number: 7256013
    Abstract: The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method can be used for measuring activities of deacetylase and acetylase, and also enables screening for substances that influence the activity of these enzymes. The deacetylase activity can be measured by a simple procedure according to the present invention.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: August 14, 2007
    Assignee: Cyclex Co., Ltd.
    Inventors: Katsuyuki Tamai, Toshiaki Miyazaki, Emi Wada, Ayumi Tatsuzawa
  • Methods for determining the acetylation level of a peptide based on sensitivity of the peptide to peptidase
    Patent number: 7033778
    Abstract: The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method can be used for measuring activities of deacetylase and acetylase, and also enables screening for substances that influence the activity of these enzymes. The deacetylase activity can be measured by a simple procedure according to the present invention.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: April 25, 2006
    Assignee: Cyclex Co., Ltd.
    Inventors: Katsuyuki Tamai, Toshiaki Miyazaki, Emi Wada, Ayumi Tatsuzawa