Patents Assigned to CYFUSE BIOMEDICAL K. K.
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Publication number: 20220331483Abstract: A material for inducing nerve regeneration in a transplantation site, or a material for recovering the function of nerve tissues in a transplantation site, the material comprising a cell structure having a thickness of at least 300 ?m that is constructed by stacking the spheroids of bone marrow-derived cells, adipose tissue-derived cells, dental pulp-derived cells, amnion-derived cells, placenta-derived cells, umbilical cord-derived cells, or umbilical cord blood-derived cells, on a needle-shaped body arranged on a substrate.Type: ApplicationFiled: May 14, 2020Publication date: October 20, 2022Applicants: CYFUSE BIOMEDICAL K.K., Shinshu University National University CorporationInventors: Tetsuya IMAMURA, Mitsuru SHIMAMURA
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Publication number: 20220315899Abstract: Long awaited is a human liver-like three-dimensional construct that makes it possible to carry out evaluation of human-specific toxicity and the like accurately and in a simple manner. The present invention provides a human liver-like three-dimensional construct comprising a heterospheroid, in which human hepatic cells and other human-derived cells which are not human hepatic cells are aggregated. This human liver-like three-dimensional construct is characterized in that the other human-derived cells are at least one selected from human hepatic stellate cells and the like, and the other human-derived cell to the human hepatic cell count ratio is at least 0.01 but less than 1.Type: ApplicationFiled: February 21, 2020Publication date: October 6, 2022Applicant: CYFUSE BIOMEDICAL K.K.Inventors: Toshihiko MAEKAWA, Eri NAGAO, Izumi IDE, Sakura KAJIYAMA
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Publication number: 20210332318Abstract: The cell structure fixing and removing system includes: an alignment base made of a silicone resin, the alignment base including a flat sticking surface to which needles with skewed cell aggregates are to be stuck; and a cell structure removing tool placed on the sticking surface between the alignment base and the cell aggregate, the cell structure removing tool including: a frame extending to correspond to an outline of the sticking surface, the frame including a puncture opening in middle, a bottom surface of the frame forming an alignment surface parallel to the sticking surface; and a porous sheet stretched and arranged on the alignment surface to close the puncture opening of the frame, the porous sheet allowing penetration by the needle, wherein an outline edge of the puncture opening in the alignment surface of the frame of the cell structure removing tool is located in the outline of the sticking surface.Type: ApplicationFiled: February 1, 2019Publication date: October 28, 2021Applicant: Cyfuse Biomedical K.K.Inventor: Yasuto KISHII
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Publication number: 20210324319Abstract: The cell structure manufacturing system including a cabinet being a closed space capable of maintaining an inside at a high cleanness, a cultivation plate supplying device configured to supply one cultivation plate of a plurality of cultivation plates to a conveying device in a cultivation plate supplying area, a transfer device including a cell aggregate injection device configured to discharge and transfer, and a sticking device including a needle-like body clamping mechanism configured to remove one needle-like body from a needle-like body supplying mechanism storing a plurality of needle-like bodies and perform gripping of the one needle-like body.Type: ApplicationFiled: February 1, 2019Publication date: October 21, 2021Applicant: CYFUSE BIOMEDICAL K.K.Inventors: Yasuto KISHII, Norihiko TOKUNAGA
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Publication number: 20210293704Abstract: A method for quality evaluation includes emitting measurement light having a wavelength of 300 nm or more and 2,000 nm or less to a cell mass and acquiring a plurality of light intensity information corresponding to each of a plurality of measuring positions in the cell mass, generating a feature amount from a variation of the acquired plurality of light intensity information, and evaluating quality of the cell mass using the generated feature amount as an index.Type: ApplicationFiled: June 4, 2021Publication date: September 23, 2021Applicants: Sumitomo Electric Industries, Ltd., Cyfuse Biomedical K.K., National University Corporation Tokai National Higher Education and Research SystemInventors: Asako MOTOMURA, Yoko SUGIYAMA, Hiroshi SUGANUMA, Akinori KIMURA, Shizuka AKIEDA, Yudai MIYAZAKI, Ryuji KATO, Mayu SHIBUTA, Ryohei YAMAMOTO
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Patent number: 10961495Abstract: The cell structure producing apparatus including needles, a sticking unit configured to detachably hold an end portion of each of the needles, descend the each of the needles with respect to a cell tray in which cell aggregates are held, stick and penetrate each of the cell aggregates with the tip end, and ascend the needle after sticking, at least one time or more, a base unit, and a control unit configured to move the sticking unit so that for the each of the needles, each of the needles sticking the cell aggregates is positioned at a predetermined position over the base unit, descend each of the needles by a predetermined amount to stick the tip end into the base unit at the predetermined position on the base unit, and control the sticking unit.Type: GrantFiled: October 30, 2017Date of Patent: March 30, 2021Assignee: CYFUSE BIOMEDICAL K.K.Inventors: Yasuto Kishii, Norihiko Tokunaga
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Publication number: 20210079333Abstract: The connection support device includes a rod-shaped member insertable into respective hollow portions of two or more cell structures, the rod-shaped member being inserted into the hollow portions, the rod-shaped member including a circular cross section having an outer diameter capable of adhering to inner surfaces of the cell structures when the rod-shaped member contracts after maturing, and a total length longer than a sum of respective lengths of the two or more cell structures, and two presser devices including clamp portions capable of being fixed to the rod-shaped member by clamping and fitting to the rod-shaped member, the rod-shaped member being made of a material with oxygen permeability.Type: ApplicationFiled: April 9, 2018Publication date: March 18, 2021Applicant: CYFUSE BIOMEDICAL K.K.Inventors: Kumika MATSUBAYASHI, Yasuto KISHII
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Publication number: 20210032585Abstract: It is solved by the rod-shaped tubular cell structure maintaining support device for cultivating a tubular cell structure including a hollow portion inside for a predetermined period of time while maintaining the hollow portion, the tubular cell structure maintaining support device including an outer diameter insertable into the hollow portion of the cell structure, and when inserted into the hollow portion, capable of allowing the tubular cell structure maintaining support device to adhere to an inner surface of the cell structure, and a penetration conduit including openings at both ends of the tubular cell structure maintaining support device, and penetrating between the openings, wherein the tubular cell structure maintaining support device has an oxygen permeable structure from the penetration conduit to an outer surface of the tubular cell structure maintaining support device.Type: ApplicationFiled: April 9, 2018Publication date: February 4, 2021Applicant: CYFUSE BIOMEDICAL K.K.Inventors: Satoshi GOJO, Daisuke KAMI, Kumika MATSUBAYASHI, Shizuka AKIEDA
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Publication number: 20200095530Abstract: The cell structure producing apparatus capable of properly piercing a cell aggregate and a cell tray are demanded. The object of the present invention is achieved by a cell structure producing apparatus that includes a movable needle-shaped body and sticks and penetrates a cell aggregate held on a cell tray, wherein the cell tray includes a frame having an opening, and a porous member that is supported at the opening by the frame and on which the cell aggregate is placeable, and a tip of the needle-shaped body is capable of penetrating through the porous member when the needle-shaped body sticks and penetrates the cell aggregate.Type: ApplicationFiled: October 10, 2017Publication date: March 26, 2020Applicant: CYFUSE BIOMEDICAL K.K.Inventors: Yasuto KISHII, Norihiko TOKUNAGA
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Publication number: 20190359929Abstract: The cell structure producing apparatus including needles, a sticking unit configured to detachably hold an end portion of each of the needles, descend the each of the needles with respect to a cell tray in which cell aggregates are held, stick and penetrate each of the cell aggregates with the tip end, and ascend the needle after sticking, at least one time or more, a base unit, and a control unit configured to move the sticking unit so that for the each of the needles, each of the needles sticking the cell aggregates is positioned at a predetermined position over the base unit, descend each of the needles by a predetermined amount to stick the tip end into the base unit at the predetermined position on the base unit, and control the sticking unit.Type: ApplicationFiled: October 30, 2017Publication date: November 28, 2019Applicant: Cyfuse Biomedical K.K.Inventors: Yasuto KISHII, Norihiko TOKUNAGA
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Patent number: 10087415Abstract: Provided are: a cell tray provided with a concave part for supporting a cell aggregate and a hole formed on the bottom of the concave part; and a device for producing a cell structure, said device being provided with the cell tray and a puncture part passing through the cell tray and the cell aggregate, characterized in that the puncture part passes through the cell aggregate supported by the concave part until the tip thereof intrudes into the hole.Type: GrantFiled: September 25, 2015Date of Patent: October 2, 2018Assignee: CYFUSE BIOMEDICAL K.K.Inventors: Koji Kuchiishi, Tadashi Tamura
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Publication number: 20160348066Abstract: Provided are: a cell tray provided with a concave part for supporting a cell aggregate and a hole formed on the bottom of the concave part; and a device for producing a cell structure, said device being provided with the cell tray and a puncture part passing through the cell tray and the cell aggregate, characterized in that the puncture part passes through the cell aggregate supported by the concave part until the tip thereof intrudes into the hole.Type: ApplicationFiled: September 25, 2015Publication date: December 1, 2016Applicant: CYFUSE BIOMEDICAL K.K.Inventors: Koji KUCHIISHI, Tadashi TAMURA
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Patent number: 9469833Abstract: The present invention provides a transplantation guide which is formed into a bottomed cylinder having a base material that allows communication of a culture fluid, wherein: a cell mass supplied from the open end side is placed on the base material, and the guide is used as a mold for forming a three-dimensional cell construct by culturing the cell mass placed on the base material by immersing the base material side in an excessive amount of a culture fluid.Type: GrantFiled: February 3, 2012Date of Patent: October 18, 2016Assignee: CYFUSE BIOMEDICAL K. K.Inventor: Koichi Nakayama
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Patent number: 9441194Abstract: A device 2 for producing a three-dimensional structural body has an accommodating plate 3 in which an accommodating recess portion 3a for accommodating a cell mass 1 is formed, a support body 4 provided with a plurality of needle-shaped bodies 6 penetrating the cell mass, a suction nozzle 19 for adsorbing/holding the cell mass, and structure 20 for moving the suction nozzle.Type: GrantFiled: June 19, 2012Date of Patent: September 13, 2016Assignees: NATIONAL UNIVERSITY CORPORATION SAGA UNIVERSITY, CYFUSE BIOMEDICAL K.K., SHIBUYA KOGYO CO., LTD.Inventors: Koichi Nakayama, Kenji Yoneda, Masahiro Sakamoto, Ichiro Koshida, Masaharu Shomura, Isao Fukamura
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Publication number: 20160022870Abstract: Provided is a method for producing a cardiac tissue spheroid or vascular tissue spheroid formed from a mixture of a myocardial cell or smooth muscle cell and at least one type of cell selected from a vascular endothelial cell and fibroblast, and a three dimensional cardiac tissue structure or three dimensional vascular tissue structure which are characterized by combining or laminating said spheroid.Type: ApplicationFiled: October 24, 2013Publication date: January 28, 2016Applicants: CYFUSE BIOMEDICAL K.K., SAGA UNIVERSITYInventors: Ryo NOGUCHI, Tadashi TAMURA, Koichi NAKAYAMA, Shigeki MORITA, Koichi NODE
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Publication number: 20140283356Abstract: A device for manufacturing a support for fixing cells of the present invention is capable of easily manufacturing a support that has needle-like bodies arranged on a base. The manufacturing device 2 is provided with a base 10, a holder 4, an insertion guide 6 and an alignment mechanism. The base 10 is retained by a holder 4. The base 10 is provided with a plurality of openings 15, into which needle-like bodies 20 are inserted and fixed. An insertion guide 6 is provided next to the holder 4 and includes slots 12 for placing a plurality of needle-like bodies 20 generally parallel to each other. The insertion guide 6 is provided with a plurality of slots 12 for placing the needle-like bodies 20 at corresponding positions to the openings 15, so that the alignment mechanism moves the insertion guide 6 such that the feed openings 12a are positioned adjacent to the openings 15.Type: ApplicationFiled: November 16, 2012Publication date: September 25, 2014Applicants: SAGA UNIVERSITY, CYFUSE BIOMEDICAL K.K.Inventor: Koichi Nakayama
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Publication number: 20130337553Abstract: The present invention provides a transplantation guide which is formed into a bottomed cylinder having a base material that allows communication of a culture fluid, wherein: a cell mass supplied from the open end side is placed on the base material, and the guide is used as a mold for forming a three-dimensional cell construct by culturing the cell mass placed on the base material by immersing the base material side in an excessive amount of a culture fluid.Type: ApplicationFiled: February 3, 2012Publication date: December 19, 2013Applicant: CYFUSE BIOMEDICAL K. K.Inventor: Koichi Nakayama