Patents Assigned to CyGene, Inc.
  • Compositions and methods of synthesis and use of novel nucleic acid structures
    Patent number: 6831072
    Abstract: The present invention is directed to a method to produce 8-amino-2′deoxyadenosine by treating 8-azido-2′deoxyadenosine with an aqueous solution of methylamine or dimethylamine.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: December 14, 2004
    Assignee: Cygene, Inc.
    Inventors: Ramón Eritja, Ramón Güimil García
  • Methods and compositions for detection of disease
    Patent number: 6709829
    Abstract: The present invention is directed to methods and compositions for detection of target analytes, comprising proteins and nucleic acids, in multiple cellular compartments. Preferred embodiments comprise the use of complement-mediated assays. Methods and compositions for monitoring multiple stages of disease and infection are presented.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: March 23, 2004
    Assignee: Cygene, Inc.
    Inventor: Elliot R. Ramberg
  • Methods and compositions for detection of specific nucleotide sequences
    Patent number: 6458540
    Abstract: Methods and compositions are provided for the detection of specific nucleic acid sequences purified from cellular or tissue sources. More particularly, the present invention includes methods and compositions for the detection of nucleic acid sequences using a protection molecule that forms a protected nucleic acid sequence (PNAS) such as a triplex or duplex nucleic acid structure that includes the target nucleic acid sequence. An assay using the methods of the present invention may include one, two or three levels of specificity to minimize false positive signals. An assay using the methods or compositions of the present invention can be performed on large amounts of purified DNA in a single test, with high levels of sensitivity, thus eliminating the need for DNA amplification procedures.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: October 1, 2002
    Assignee: CyGene, Inc.
    Inventor: Elliot R. Ramberg
  • Methods and compositions for detection of specific nucleotide sequences
    Patent number: 6100040
    Abstract: Methods and compositions are provided for the detection of specific nucleic acid sequences purified from cellular or tissue sources. More particularly, the present invention includes methods and compositions for the detection of nucleic acid sequences using a protection molecule that forms a protected nucleic acid sequence (PNAS) such as a triplex or duplex nucleic acid structure that includes the target nucleic acid sequence. An assay using the methods of the present invention may include one, two or three levels of specificity to minimize false positive signals. An assay using the methods or compositions of the present invention can be performed on large amounts of purified DNA in a single test, with high levels of sensitivity, thus eliminating the need for DNA amplification procedures.
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: August 8, 2000
    Assignee: Cygene, Inc.
    Inventor: Elliot R. Ramberg
  • Methods and compositions for detection of specific nucleotide sequences
    Patent number: 5962225
    Abstract: Methods and compositions are provided for the detection of specific nucleic acid sequences purified from cellular or tissue sources. More particularly, the present invention includes methods and compositions for the detection of nucleic acid sequences using a protection molecule that forms a protected nucleic acid sequence (PNAS) such as a triplex or duplex nucleic acid structure that includes the target nucleic acid sequence. An assay using the methods of the present invention may include one, two or three levels of specificity to minimize false positive signals. An assay using the methods or compositions of the present invention can be performed on large amounts of purified DNA in a single test, with high levels of sensitivity, thus eliminating the need for DNA amplification procedures.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: October 5, 1999
    Assignee: CyGene, Inc.
    Inventor: Elliot R. Ramberg