Patents Assigned to Cygnus Therapeutic Systems
  • Ultrasound-enhanced delivery of materials into and through the skin
    Patent number: 5115805
    Abstract: A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultrasound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: May 26, 1992
    Assignees: Cygnus Therapeutic Systems, The Regents of the University of California
    Inventors: Durairaj Bommannan, Hirohisa Okuyama, Richard H. Guy, Paul Stauffer, Gordon L. Flynn
  • Biphasic transdermal drug delivery device
    Patent number: 5091186
    Abstract: A transdermal drug delivery system in which drug delivery is biphasic is provided. Drug is delivered at a therapeutically effective rate during an initial, delivery phase, typically of about 10 to 14 hours, followed by a subsequent, secondary phase during which virtually no drug is delivered. Substantially all of the drug initially loaded into the device is delivered within the initial, delivery phase.
    Type: Grant
    Filed: August 15, 1989
    Date of Patent: February 25, 1992
    Assignee: Cygnus Therapeutic Systems
    Inventors: Jesus Miranda, Gary W. Cleary
  • Transdermal administration of buprenorphine
    Patent number: 5069909
    Abstract: Method and laminated composite for administering buprenorphine transdermally to treat pain. The composite comprises an impermeable backing layer and a reservoir layer containing buprenorphine and optionally a permeation enhancer combined with a pressure-sensitive adhesive with the amounts of buprenorphine and optional enhancer being sufficient to cause the buprenorphine to pass through the skin at a rate in excess of about 0.05 mcg/cm.sup.2 /hr.
    Type: Grant
    Filed: June 20, 1990
    Date of Patent: December 3, 1991
    Assignee: Cygnus Therapeutic Systems
    Inventors: Kuldeepak Sharma, Samir D. Roy, Eric J. Roos
  • Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
    Patent number: 5059426
    Abstract: Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The composition contains diethylene glycol monoethyl or monomethyl ether in addition to an ester component such as propylene glycol monolaurate, methyl laurate or the like. The compositions are particularly useful in conjunction with the transdermal administration of steroid drugs such as progestogens and estrogens. Methods and drug delivery systems for using the enhancer compositions are provided as well.
    Type: Grant
    Filed: June 12, 1990
    Date of Patent: October 22, 1991
    Assignee: Cygnus Therapeutic Systems
    Inventors: Chia-Ming Chiang, Gary W. Cleary
  • Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
    Patent number: 5053227
    Abstract: Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The composition contains diethylene glycol monoethyl or monomethyl ether in addition to an ester component such as propylene glycol monolaurate, methyl laurate or the like. The compositions are particularly useful in conjunction with the transdermal administration of steroid drugs such as progestogens and estrogens. Methods and drug delivery systems for using the enhancer compositions are provided as well.
    Type: Grant
    Filed: June 12, 1990
    Date of Patent: October 1, 1991
    Assignee: Cygnus Therapeutic Systems
    Inventors: Chia-Ming Chiang, Gary W. Cleary