Patents Assigned to Cynvenio Biosystems, Inc.
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Patent number: 10130951Abstract: Provided are devices for recovery of cells from a microfluidic device. In particular, provided are open-ended conical tubes for recovery of cells from a microfluidic device and methods of use. In some embodiments, the open-ended conical tubes comprise: i) a nipple portion (7), wherein the nipple portion (7) comprises a length in the range of 0.2 to 0.3 inches, a diameter in the range of 0.2 to 0.3 inches, wherein the nipple portion (7) comprises a narrow orifice; ii) a conical portion (5) attached to and in fluid communication with the nipple portion, wherein the conical portion (5) has a length in the range of 1.0 to 1.Type: GrantFiled: September 11, 2013Date of Patent: November 20, 2018Assignee: Cynvenio Biosystems, Inc.Inventors: Robert Shartle, Behrad Vahidi, William M. Strauss
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Patent number: 9988686Abstract: Provided are stimulus-sensitive microparticles and their use, e.g., in tracking the efficiency of recovery of a rare cell population (e.g., circulating tumor cells) from a mixture of cells; and in supplying control nucleic acids to index a molecular assay independent of the rare cell selection steps.Type: GrantFiled: September 27, 2013Date of Patent: June 5, 2018Assignee: Cynvenio Biosystems, Inc.Inventor: William M. Strauss
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Patent number: 9802197Abstract: Provided herein are fluid reservoirs or hoppers for controlled delivery of liquid biological sample to a microfluidic device.Type: GrantFiled: September 11, 2013Date of Patent: October 31, 2017Assignee: Cynvenio Biosystems, Inc.Inventors: Behrad Vahidi, Bernard Strong, Samuel Ferguson
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Publication number: 20150231632Abstract: Provided are devices for recovery of cells from a microfluidic device.Type: ApplicationFiled: September 11, 2013Publication date: August 20, 2015Applicant: CYNVENIO BIOSYSTEMS, INC.Inventors: Robert SHARTLE, Behrad VAHIDI, William M. STRAUSS
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Publication number: 20150224501Abstract: Provided herein are fluid reservoirs or hoppers for controlled delivery of liquid biological sample to a microfluidic device.Type: ApplicationFiled: September 11, 2013Publication date: August 13, 2015Applicant: CYNVENIO BIOSYSTEMS, INC.Inventors: Behrad Vahidi, Bernard Strong, Samuel Ferguson
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Publication number: 20150211072Abstract: Provided are stimulus-sensitive microparticles and their use, e.g., in tracking the efficiency of recovery of a rare cell population (e.g., circulating tumor cells) from a mixture of cells; and in supplying control nucleic acids to index a molecular assay independent of the rare cell selection steps.Type: ApplicationFiled: September 27, 2013Publication date: July 30, 2015Applicant: CYNVENIO BIOSYSTEMS, INC.Inventor: William M. STRAUSS
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Publication number: 20150167070Abstract: Provided are methods for validating the presence and character of genomic mutations, particularly single nucleotide polymorphisms (SNPs), by parallel amplification of a portion or the whole genome with at least two different DNA polymerases.Type: ApplicationFiled: July 18, 2013Publication date: June 18, 2015Applicant: CYNVENIO BIOSYSTEMS, INC.Inventor: William M. Strauss
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Publication number: 20120301883Abstract: The invention relates generally to fluid processing and, in particular aspects, processing fluids for detection, selection, trapping and/or sorting of particulate moieties. Sheath flow devices described allow isolation of target species from fluid samples while avoiding non-specific binding of unwanted species to the surfaces of the separation device. Biological fluid processing, detection, sorting or selection of cells, proteins, and nucleic acids is described. The invention finds particular use in diagnostic settings, analyzing a patient's medical condition, monitoring and/or adjusting a therapeutic regimen and producing cell based products.Type: ApplicationFiled: August 3, 2012Publication date: November 29, 2012Applicant: CYNVENIO BIOSYSTEMS, INC.Inventors: Paul Pagano, Yanting Zhang, Jiangrong Karen Qian, Hyongsok Tom Soh, Paul W. Dempsey, Andre' De Fusco
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Patent number: 8263387Abstract: The invention relates generally to fluid processing and, in particular aspects, processing fluids for detection, selection, trapping and/or sorting of particulate moieties. Sheath flow devices described allow isolation of target species from fluid samples while avoiding non-specific binding of unwanted species to the surfaces of the separation device. Biological fluid processing, detection, sorting or selection of cells, proteins, and nucleic acids is described. The invention finds particular use in diagnostic settings, analyzing a patient's medical condition, monitoring and/or adjusting a therapeutic regimen and producing cell based products.Type: GrantFiled: June 10, 2010Date of Patent: September 11, 2012Assignee: Cynvenio Biosystems, Inc.Inventors: Paul Pagano, Yanting Zhang, Jiangrong Karen Qian, Hyongsok Tom Soh, Paul W. Dempsey, Andreā² De Fusco
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Publication number: 20110137018Abstract: A system for sorting and trapping magnetic target species includes a microfluidic chamber designed to receive and then temporarily hold magnetic particles in place within the module. A pre-processing module may mix a sample and magnetic particles to cause certain species in the sample to be labeled. The micorfluidic chamber may include a mechanism to move magnetic particles within the chamber. A post-processing module or the microfluidic chamber may be used to separate the labeled species from the magnetic particles by adding a release reagent. The magnetic particles and/or their payloads may be released and separately collected at an outlet of the chamber or the post-processing module.Type: ApplicationFiled: April 16, 2009Publication date: June 9, 2011Applicant: CYNVENIO BIOSYSTEMS, INC.Inventors: David A. Chang-Yen, Jafar Darabi, Yanting Zhang, Paul Pagano, Frederick W. Gluck
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Publication number: 20110127222Abstract: A system for sorting and trapping magnetic target species includes a microfluidic trapping chamber designed to receive and then temporarily hold magnetic particles in place within the module. An external magnetic source moves relatives to the fluid chamber as the magnetic particles flow the device in the fluidic medium. The magnetic particles flowing into the module are trapped there while the other sample components (non-magnetic) continuously flow through and out of the station, thereby separating and concentrating the species captured on the magnetic particles. The magnetic particles and/or their payloads may be released and separately collected at an outlet after the sample passes through the trapping module.Type: ApplicationFiled: March 19, 2009Publication date: June 2, 2011Applicant: CYNVENIO BIOSYSTEMS, INC.Inventors: David A. Chang-Yen, Jafar Darabi, Yanting Zhang, Paul Pagano
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Publication number: 20110003303Abstract: The invention relates generally to fluid processing and, in particular aspects, processing fluids for detection, selection, trapping and/or sorting of particulate moieties. Sheath flow devices described allow isolation of target species from fluid samples while avoiding non-specific binding of unwanted species to the surfaces of the separation device. Biological fluid processing, detection, sorting or selection of cells, proteins, and nucleic acids is described. The invention finds particular use in diagnostic settings, analyzing a patient's medical condition, monitoring and/or adjusting a therapeutic regimen and producing cell based products.Type: ApplicationFiled: June 10, 2010Publication date: January 6, 2011Applicant: CYNVENIO BIOSYSTEMS, INC.Inventors: Paul Pagano, Yanting Zhang, Jiangrong Karen Qian, Hyongsok Tom Soh, Paul W. Dempsey, Andre' De Fusco
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Publication number: 20100317093Abstract: Flexible pouch and flexible cartridge devices for fluid sample processing, related methods of making and using, related manufacturing systems and related instrumentation systems are described. Flexible pouches provide broad advantage in a wide variety of fields by overcoming the need for complex instrumentation, dedicated devices, and relatively high cost in conventional fluid sample devices. Flexible cartridge devices are particularly advantageous in control of fluid handling, rapid adaptation to a number of configurations by the end user, multiple uses for a single configuration, and in cost and ease of manufacture.Type: ApplicationFiled: June 10, 2010Publication date: December 16, 2010Applicant: CYNVENIO BIOSYSTEMS, INC.Inventors: Marek Turewicz, Paul Pagano, Andre' De Fusco, David Sauvageau