Abstract: The purpose of the invention is to promote diffusion of an active ingredient contained in a supplied liquid agent under a surface layer, using a compact configuration. A diffusion promotion device comprises a first cylindrical member and a second cylindrical member. In a state in which a liquid agent has been or is being supplied to an object from a liquid agent supply unit of a liquid agent supply device accommodated in an internal accommodation space of the diffusion promotion device, when a current path is formed between a first electrode formed on a side surface of the first cylindrical member and a second electrode formed on a tip end portion of the second cylindrical member through a surface layer portion of the object, diffusion of the active ingredient contained in the liquid agent under the surface layer of the object (for example, the surface of the skin) is promoted is promoted.

Abstract: The purpose of the present invention is to provide a therapeutic agent for demyelinating diseases in which a culture supernatant of immortalized mesenchymal stem cells into which specific genes are incorporated serves as an active ingredient. Provided is a therapeutic agent for demyelinating diseases in which a culture supernatant of immortalized mesenchymal stem cells into which either the hTERT or pTERT gene and the bmi-1 gene, the HPV-E6 gene, and the HPV-E7 gene are incorporated serves as an active ingredient. The mesenchymal stem cells are preferably of human or porcine origin, and the culture supernatant is preferably obtained by culturing the mesenchymal stem cells for 24-96 hours and contains a component that acts on the receptor c-MET of hepatocyte growth factor (HGF).

Abstract: The object of the present invention is to provide a preventive and/or therapeutic agent for pressure ulcers comprising a conditioned medium of immortalized mesenchymal stem cells to which specific genes are introduced as an active ingredient. The present invention provides the preventive and/or therapeutic agent for pressure ulcers comprising the conditioned medium of immortalized mesenchymal stem cells, to which hTERT or pTERT gene, bmi-1 gene, HPV-E6 gene, and HPV-E7 gene are introduced, as an active ingredient. Here, the mesenchymal stem cells are preferably obtained from either human or swine.