Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
Type:
Grant
Filed:
December 16, 2021
Date of Patent:
March 19, 2024
Assignee:
Cyteir Therapeutics, Inc.
Inventors:
Jean-Marc Lapierre, Casey Cameron McComas, Joseph Vacca
Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula: in combination with a PARP inhibitor, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
Type:
Grant
Filed:
March 25, 2020
Date of Patent:
March 21, 2023
Assignee:
Cyteir Therapeutics, Inc.
Inventors:
Alfredo C. Castro, Melinda Day, Tyler Maclay, Casey Cameron McComas, Kevin Mills, Joseph Vacca
Abstract: This application is directed to inhibitors of RAD51, and methods for their use, such as to treat or prevent conditions involving mitochondrial defects.
Type:
Grant
Filed:
July 11, 2018
Date of Patent:
April 5, 2022
Assignee:
Cyteir Therapeutics, Inc.
Inventors:
Alfredo C. Castro, Casey Cameron McComas, Joseph Vacca
Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
Type:
Grant
Filed:
March 12, 2020
Date of Patent:
February 15, 2022
Assignee:
Cyteir Therapeutics, Inc.
Inventors:
Jean-Marc Lapierre, Casey Cameron McComas, Joseph Vacca
Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
Type:
Grant
Filed:
January 6, 2020
Date of Patent:
August 10, 2021
Assignee:
Cyteir Therapeutics, Inc.
Inventors:
Alfredo C. Castro, Casey Cameron McComas, Joseph Vacca, Tyler Maclay
Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
Type:
Grant
Filed:
September 11, 2018
Date of Patent:
March 17, 2020
Assignee:
Cyteir Therapeutics, Inc.
Inventors:
Alfredo C. Castro, Casey Cameron McComas, Joseph Vacca, Tyler Maclay
Abstract: This application is directed to inhibitors of RAD51 represented by the following structural formula, and methods for their use, such as to treat cancer, autoimmune diseases, immune deficiencies, or neurodegenerative diseases.
Type:
Grant
Filed:
December 31, 2018
Date of Patent:
July 2, 2019
Assignee:
Cyteir Therapeutics, Inc.
Inventors:
Alfredo C. Castro, Casey Cameron McComas, Joseph Vacca, Tyler Maclay