Patents Assigned to Cytiva Sweden AB
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Patent number: 11969669Abstract: The invention relates to containers or bags for chromatographic media and methods of packing chromatography columns using such containers. The bags may be used for storing and/or transporting chromatographic media and can be inserted directly into the chamber of a chromatography column in readiness for use.Type: GrantFiled: March 9, 2022Date of Patent: April 30, 2024Assignee: Cytiva Sweden ABInventor: Klaus Gebauer
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Patent number: 11961295Abstract: A method of automated configuration in a bioprocess system and to verify a process defined by a flow path representation. The method comprises the steps of: capturing one image of the bioprocess system comprising tubing for the fluid communication between units of the bioprocess system; analyzing the captured image to identify the tubing connecting units of the bioprocess system; producing a processed representation from the captured image wherein at least a part of the tubing is identified; and comparing the processed representation with the flow path representation to verify their functional concordance.Type: GrantFiled: August 24, 2022Date of Patent: April 16, 2024Assignee: Cytiva Sweden ABInventors: Petra Bangtsson, Johan Arthursson, Key Hyckenberg, Lotta Hedkvist
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Patent number: 11938418Abstract: Certain embodiments of the invention provides a method for monitoring level of saturation of a chromatography media in a column, which method comprises measuring a first pressure at the inlet of an unloaded column; measuring a second pressure at the inlet from a loaded column; and comparing the first and second pressure measurement to determine the level of saturation of the chromatography media. Embodiments of the invention also provide related methods for controlling a chromatography system and methods for controlling a periodic counter current chromatography system, as well as a chromatography system suitable for use with the novel methods.Type: GrantFiled: December 15, 2015Date of Patent: March 26, 2024Assignee: Cytiva Sweden ABInventor: Karol Maciej Lacki
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Patent number: 11927503Abstract: The present invention relates to a computer implemented method for determining a weld integrity test result performed by a system configured to aseptically transferring cells to a container (BR), the method comprising welding (710) a vial to a connector to obtain a fluid-tight seal between the vial (V) and a connector (C), the connector being provided with a pair of conduits each having one end protruding through the connector and into the vial, sealing (720) an opposite end of one of the conduits, generating (730) a fluid pressure different to an ambient fluid pressure at an opposite end of the other conduit, measuring (740) a fluid pressure within at least one of the conduits, determining (750) a fluid pressure change based on the ambient pressure and the measured fluid pressure, determining (760) the weld integrity test result as pass or as fail based on the fluid pressure change.Type: GrantFiled: September 9, 2019Date of Patent: March 12, 2024Assignee: Cytiva Sweden ABInventors: Sameera Simha Hindupur, Manoj Kumar Ramakrishna, Andreas Castan, Swapnil Puranik, Klaus Gebauer
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Publication number: 20240076605Abstract: The present invention relates to a method for controlling process parameters in a bioreactor when producing a target product with a pre-determined critical to quality, CTQ, profile. The method comprises: monitoring (S20) at least one product quality attribute, PQA, for the target product; identifying (S30) trends and/or deviations by comparing the monitored at least one PQA to the CTQ profile of the target product; and controlling (S40) process parameters of the bioreactor based on the identified trends and/or deviations to maintain the target product within the CTQ profile.Type: ApplicationFiled: February 1, 2022Publication date: March 7, 2024Applicant: CYTIVA SWEDEN ABInventors: ANDREAS AXÉN, HELENA VESTERBERG, MAGNUS WETTERHALL, CAMILLA ESTMER NILSSON
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Patent number: 11886156Abstract: A system for providing an improved way of user intuitive visual management of bioprocess automation is disclosed. The system includes a processor and a memory. The processor is configured to present a graphical presentation of the bioprocess automation script and results associated with execution of the bioprocess automation script of a bioprocess, wherein the graphical presentation comprises an anticipated result and an anticipated flow path associated with the bioprocess; and modify the graphical presentation by varying at least one of the anticipated result and the anticipated flow path.Type: GrantFiled: December 22, 2020Date of Patent: January 30, 2024Assignee: Cytiva Sweden ABInventors: Dalesh Dharamshi, Sudheer Mygapula
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Patent number: 11867330Abstract: A connector for forming a substantially aseptic connection is provided, said connector having a connector member a coupling end with a coupling element for engaging a similar coupling element on a similar connector to form a seal. A method for connecting and disconnecting two such connectors is also provided.Type: GrantFiled: May 29, 2019Date of Patent: January 9, 2024Assignee: Cytiva Sweden ABInventor: Klaus Gebauer
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Patent number: 11862335Abstract: A method, system, gateway and computer program for remote controlling and monitoring of at least one instrument, for example a bioproces sing instrument. The system can comprise: at least one instrument to be controlled and/or monitored; at least one instrument server connected to the at least one instrument, said instrument server comprising an instrument control software; at least one gateway connected to the at least one instrument server; a transferring means provided in the at least one instrument server, said transferring means being arranged to receive information from the at least one connected instrument and forward said information to the at least one gateway.Type: GrantFiled: December 28, 2022Date of Patent: January 2, 2024Assignee: Cytiva Sweden ABInventors: Key Hyckenberg, Kjell Karlsson, Stefan Willehadson, Orjan Bo Grelsson
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Patent number: 11850391Abstract: Aseptic connectors are described. An aseptic connector includes a first connection unit and a second connection unit provided with at least one first and second openings orientated to substantially coincide when said first and second connection units are connected to each other. The first and second openings are sealed by at least one film, so that the contact between the film and each connection unit is aseptic. The at least one film is adapted to be mated with a corresponding film on the other connection unit; and the mated films are adapted to be pulled out together two and two after mating such that corresponding first and second openings are mated aseptically.Type: GrantFiled: February 12, 2021Date of Patent: December 26, 2023Assignee: CYTIVA SWEDEN ABInventors: Eric Faldt, Klaus Gebauer
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Patent number: 11846635Abstract: The invention discloses an immunoglobulin-binding magnetic bead, comprising a porous matrix and one or more magnetic particles embedded in said matrix, wherein said matrix comprises a porous polymer and at least 10 mg/ml Fc-binding proteinaceous ligands covalently coupled to said porous polymer.Type: GrantFiled: December 21, 2017Date of Patent: December 19, 2023Assignee: CYTIVA SWEDEN ABInventors: Ola Lind, Klaus Gebauer, Eric Faldt, Nils Norrman, Ronnie Palmgren, Jesper Hedberg, Niklas Jungnelius, Karl Liderfelt, Anita Solbrand
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Patent number: 11820084Abstract: Disclosed is an automated method (54) which includes directing rays from a source (34) to a tube (38) disposed between relatively movable first and second sealing plates (20, 32), capturing an image (70) of at least a portion of the tube (38) by an image capturing device (26), and transferring the captured image (70) to a processing device (24). The method (54) also includes determining a plurality of tube parameters by the processing device (24) based on the captured image (70), using an image processing technique and determining a plurality of sealing parameters from a database (44) by the processing device (24) based on the determined plurality of tube parameters. Additionally, the method (54) includes controlling the drive unit (22) and a heater (36) by the processing device (24) influenced by the determined plurality of sealing parameters, to respectively compress the tube (36) and perform heat sealing of the tube (38).Type: GrantFiled: December 18, 2019Date of Patent: November 21, 2023Assignee: Cytiva Sweden ABInventors: Hanish Lakhani, Preetam Hosamani, Nishu Garg, Bhaskaran Savarimuthu, Srihari Kannuri, Juzar Mazhar Ezzy, Ramu Balaguru
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Patent number: 11815451Abstract: Disclosed is a method for measuring the absorbance of light of a substance in a solution in a measuring cell (23; 223?), said method comprising the steps of: transmitting (S1) a first light beam (27; 27?) from a light source (25; 25?) towards a beam splitter (29; 29?); dividing (S3) the first light beam (27; 27?) into a signal light ray (31; 31?) and a reference light ray (33; 33?) by the beam splitter (29; 29?); modulating (S5) the signal light ray (31; 31?); modulating the reference light ray (33; 33?); providing (S9) the measuring cell (23; 23?) such that the signal light ray (31; 31?) passes through the measuring cell; detecting (S11) a signal in a detector (39; 39?), which signal is the combined signal intensity of the signal light ray (31; 31?) and the reference light ray (33; 33?) detected by the detector (39; 39?); performing synchronous detection (S15) of the detected signal in order to reconstruct the intensities of the signal light ray (31; 31?) and the reference light ray (33; 33?) from the combinType: GrantFiled: June 27, 2017Date of Patent: November 14, 2023Assignee: Cytiva Sweden ABInventor: Mikael Anders Hornqvist
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Patent number: 11815075Abstract: A multiple cavity reciprocating positive displacement pump (200) comprises a plurality of pump cavities (222), each pump cavity (222) including at least an inlet valve (228) and an outlet valve (231), wherein respective inlet valves (228) are in fluid communication with a common inlet (224) and respective outlet valves (231) are in fluid communication with a common outlet (238), and wherein the pump cavities (222) are arranged about a pump axis (AR) and around said common inlet (224) and said common outlet (238).Type: GrantFiled: September 6, 2018Date of Patent: November 14, 2023Assignee: Cytiva Sweden ABInventors: Andreas Torbjorn Lundin, Klas Marteleur, Mats Lundkvist, Andreas Marcstrom, David Gronowitz
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Patent number: 11801456Abstract: A system for preparing solutions for chromatography application is disclosed. The system comprises a T-joint for preparing a buffer solution by mixing at least one first solution and a second solution. The T-joint receives the second solution from a solution supply unit connected to the T-joint. Further one or more low pressure pumps supply the one or more first solutions into the T-joint. The high pressure pump collects the buffer solution and delivers it to a chromatography apparatus.Type: GrantFiled: January 25, 2021Date of Patent: October 31, 2023Assignee: Cytiva Sweden ABInventor: Bjorn Markus Olovsson
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Patent number: 11802297Abstract: The present invention relates to an improved method for cell line development (CLD) which is generally applicable to production of any therapeutic protein that can be produced using mammalian Cell lines and in particular Chinese Hamster Ovary (CHO) cells. The method combines site-directed integration (SDI), expression construct components improving the post-transcriptional processing of the gene of interest (GOI) and the introduction of a onetime pre-CLD host cell line selection workflow to generate a production competent cell line that can then be used in multiple CLD efforts using SDI from that point on.Type: GrantFiled: February 23, 2018Date of Patent: October 31, 2023Assignee: Cytiva Sweden ABInventors: Daniel Ivansson, Andreas Castan
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Patent number: 11796536Abstract: The present invention provides a method of assaying a sample solution for the presence of a first analyte comprising: (a) providing a sensor surface having a ligand immobilized thereto; (b) flowing the sample solution over the sensor surface; and (c) detecting the presence or absence of binding of the analyte to the ligand on the sensor surface; wherein the contact time between the sample solution and the immobilized ligand is less than 15 seconds.Type: GrantFiled: July 17, 2020Date of Patent: October 24, 2023Assignee: Cytiva Sweden ABInventor: Olof Karlsson
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Patent number: 11781659Abstract: A method for controlling at least one valve provided to a tube in a bioprocess flow system, said method comprising the steps of: —controlling the at least one valve to be in a first state, which is an open state when a flow through the tube should be allowed; —controlling the at least one valve to be in a second state during some parts of a process run in the system, said second state is a closed state were a first closing force is provided; and—controlling the at least one valve to be in a third state during some parts of a process run in the system, said third state is a closed state were a second closing force is provided which is a higher force than the first closing force.Type: GrantFiled: March 21, 2019Date of Patent: October 10, 2023Assignee: CYTIVA SWEDEN ABInventor: Klaus Gebauer
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Publication number: 20230313100Abstract: A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.Type: ApplicationFiled: March 28, 2023Publication date: October 5, 2023Applicant: CYTIVA SWEDEN ABInventors: KLAUS GEBAUER, NAGARAJ RAGHAVENDRA RAO, ANINDYA KANTI DE, ANINDYA SENGUPTA, MATS OLSSON, COLIN R. TUOHEY, JONATHAN A. KENNEY, RICHARD LEE DAMREN, RALPH STANKOWSKI, NIRMAL KUMAR THANIKACHALAM
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Patent number: 11773358Abstract: A method for controlling at least one culture parameter in a bioreactor bag (1; 31 a, 31 b) provided in a bioreactor system, the method comprising the steps of: providing bioreactor information to a control unit (5; 35) controlling the bioreactor system; controlling the at least one culture parameter in dependence of the bioreactor information.Type: GrantFiled: April 30, 2019Date of Patent: October 3, 2023Assignee: Cytiva Sweden ABInventors: Klaus Gebauer, Eva Lindskog, Lars Magnusson
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Patent number: 11740210Abstract: Disclosed is a chromatography system (100) comprising: plural modules (1-25) including at least one pump and a column valve unit (8) connectable to plural chromatography columns; and a controller (600), the controller being operable to control the or each pump and the column valve to perform different chromatographic processes, including chromatography employing just one column, as well as chromatography employing two or more columns by selective valve opening in said unit. The system includes a housing (110) into which the plural modules (1-25) are interchangeably mountable in apertures of one generally vertical face of housing, the modules are adapted for selective fluidic interconnection by tubing substantially at said one face such that in use the modules and tubing occupy a generally vertically extending volume to minimize the footprint of the system.Type: GrantFiled: September 21, 2018Date of Patent: August 29, 2023Assignee: CYTIVA SWEDEN ABInventors: Nils Stafstrom, Lars Olof Nils Rosengren, Kerstin Elisabet Erickson, Tomas Yngve Agren, Yngve L. Hareland, Tim Francois, Anita Jonsson, Jeanne Cheng, Anna Andersson