Abstract: A buffer management system includes at least one workstation configured to support a supply of concentrated buffer solution and an inline dilution skid having a manifold and at least one workstation to support delivery of diluted (surge) buffers from the inline dilution skid. The latter workstation also serves to supply ready-made (diluted) buffers to a bioprocessing unit. The manifold is in fluid communication with the supply of concentrated buffer solution and is adapted to be placed in fluid communication with a source of water for injection (WFI). The inline dilution skid is configured to variably mix the supply of concentrated buffer solution and the source of WFI to obtain a range of diluted buffer solutions. Processes for automatically identifying the arrangement of buffer solutions in a bioprocessing application use signals from various sensors to identify the fluid connections between components of the system.

Abstract: A dissolution system includes a dissolution line and a bypass line. The dissolution line fluidly couples a biocontainer, a pump, a cartridge, an upstream filter, and a downstream filter in a circulation loop. The bypass line is in fluid communication with the dissolution line at an upstream junction and a downstream junction such that the bypass line is in parallel relationship with the cartridge. A flow control system is configured to control the flow of fluid through the cartridge such that the flow of fluid through at least one of the dissolution line and the bypass line is selectively controlled based upon a pressure in the dissolution line downstream of the cartridge between the cartridge and the biocontainer.

Abstract: A buffer management system includes at least one workstation configured to support a supply of concentrated buffer solution and an inline dilution skid having a manifold and at least one workstation to support delivery of diluted (surge) buffers from the inline dilution skid. The latter workstation also serves to supply ready-made (diluted) buffers to a bioprocessing unit. The manifold is in fluid communication with the supply of concentrated buffer solution and is adapted to be placed in fluid communication with a source of water for injection (WFI). The inline dilution skid is configured to variably mix the supply of concentrated buffer solution and the source of WFI to obtain a range of diluted buffer solutions. Processes for automatically identifying the arrangement of buffer solutions in a bioprocessing application use signals from various sensors to identify the fluid connections between components of the system.

Abstract: A filtration assembly is provided, comprising a reservoir for holding a sample to be filtered, the reservoir having open top and bottom ends, and inwardly facing arms arranged at the bottom end, the reservoir having an elastic side wall; a fluid port in fluid communication with the reservoir; a porous microorganism-capturing filter element disposed across a flow path between the reservoir and the port, the filter element being releasably retained by the inwardly facing arms; an absorbent pad arranged below the filtration element and the inwardly facing arms, disposed across the flow path between the reservoir and the port; a base detachably mounted to the reservoir, the base including the port, and a support surface for supporting the pad; wherein compressing the elastic side wall releases the filter element from the inwardly facing arms after the base is detached from the reservoir.

Abstract: A fluid distribution system includes single use distributor manifolds each having a distributor manifold inlet and a plurality of distributor manifold outlets in fluid communication with the distributor manifold inlet. A set of single use filler manifolds can be sequentially connected to a respective one of the outlets of a single use distributor manifold immediately upstream of the connection point of the set of single use filler manifolds. In embodiments, an upstream distributor manifold can be used to feed fluid to a set of intermediary distributor manifolds where the set of intermediary distributor manifolds corresponds to the number of outlets of the upstream distributor manifold.

Abstract: A connector is provided comprising a hollow connector body having a central aperture and a hollow tube that is rotatable within the central aperture without rotating the hollow connector body.

Abstract: A fluid distribution system includes single use distributor manifolds each having a distributor manifold inlet and a plurality of distributor manifold outlets in fluid communication with the distributor manifold inlet. A set of single use filler manifolds can be sequentially connected to a respective one of the outlets of a single use distributor manifold immediately upstream of the connection point of the set of single use filler manifolds. In embodiments, an upstream distributor manifold can be used to feed fluid to a set of intermediary distributor manifolds where the set of intermediary distributor manifolds corresponds to the number of outlets of the upstream distributor manifold.

Abstract: Tubing retainers use with sensors, sensing systems including the tubing retainers, and methods of using the tubing retainers and sensing systems are disclosed.

Abstract: Methods and systems for determining the integrity of a filter device are provided.

Abstract: Tubing retainers use with sensors, sensing systems including the tubing retainers, and methods of using the tubing retainers and sensing systems are disclosed.

Abstract: Methods and systems for recovering retained filtered fluid are provided.

Abstract: A tank with a door locking mechanism for use in bioprocessing, and methods of using the door locking mechanism, is provided.