Abstract: The disclosure relates to devices and methods for analyzing particles in a sample. In various embodiments, the present disclosure provides devices and methods for cytometry and additional analysis. In various embodiments, the present disclosure provides a cartridge device and a reader instrument device, wherein the reader instrument device receives, operates, and/or actuates the cartridge device. In various embodiments, the present disclosure provides a method of using a device as disclosed herein for analyzing particles in a sample.

Abstract: Methods and apparatuses for measuring parameters based on the presence or absence of fluid at a plurality of fluid sensing zones in a disposable cassette are described herein. In an embodiment, a fluidic device includes a disposable cartridge including a fluid channel, an instrument configured to receive the disposable cartridge, the instrument including at least one sensor having a plurality of fluid sensing zones spaced along the fluid channel when the disposable cartridge is received by the disposable cartridge, each fluid sensing zone configured to determine a presence or absence of fluid at a respective portion of the fluid channel, and a control unit configured to determine at least one of a fluid volume, a volume displacement, a flow rate, a flow velocity or a volume ratio of gas bubbles of the fluid based on the presence or absence of the fluid at each of the fluid sensing zones.

Abstract: A fluidic device for a cartridge for testing biological samples is disclosed herein. In an embodiment, the fluidic device includes a fluidic chamber, at least one microfluidic channel in fluid communication with the fluidic chamber, a venting port configured to apply a pneumatic force to the fluidic chamber, at least one passive valve located within the at least one microfluidic channel and configured to allow or stop fluid flow through the at least one microfluidic channel based on a pressure difference, and a controller configured to control the pneumatic force applied to the fluidic chamber via the venting port.