Patents Assigned to Cytokinetics
  • Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
    Patent number: 8299248
    Abstract: Provided are methods for treating myasthenia gravis in a patient, comprising administering to the patient an effective amount of at least one chemical entity chosen from compounds of Formula I and compounds of Formula II: and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: May 14, 2010
    Date of Patent: October 30, 2012
    Assignee: Cytokinetics, Incorporated
    Inventors: Aaron Hinken, Fady Malik, Malar Pannirselvam, Alan Russell
  • Certain chemical entities, compositions and methods
    Patent number: 8293761
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: October 23, 2012
    Assignee: Cytokinetics, Inc.
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, Jr.
  • Modulating skeletal muscle
    Patent number: 8227603
    Abstract: Methods of identifying skeletal muscle activators are provided. Methods of activating skeletal muscle using skeletal muscle activators are also provided.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: July 24, 2012
    Assignee: Cytokinetics, Inc.
    Inventors: Alan Russell, Fady Malik, Jim Hartman, Richard Hansen
  • Imidazopyridinyl benzamide mitotic kinesin inhibitors
    Patent number: 8207340
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: June 26, 2012
    Assignee: Cytokinetics, Incorporated
    Inventors: Xiangping Qian, Andrew I. McDonald, Han-Jie Zhou, Luke W. Ashcraft, Bing Yao, Hong Jiang, Jennifer Kuo Chen Huang, Jianchao Wang, David J. Morgans, Jr., Bradley P. Morgan, Gustave Bergnes, Dashyant Dhanak, Steven D. Knight, Nicholas D. Adams, Cynthia A. Parrish, Kevin Duffy, Duke Fitch, Rosanna Tedesco
  • Heterocyclic sulfonamides
    Patent number: 8202859
    Abstract: Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: June 19, 2012
    Assignee: Cytokinetics, Inc.
    Inventors: Bradley Paul Morgan, Fady Malik, Erica Anne Kraynack, Alexander Ramon Muci, Xiangping Qian, David J. Morgans, Jr.
  • Imidazopyridinyl benzamide mitotic kinesin inhibitors
    Patent number: 8163919
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: April 24, 2012
    Assignee: Cytokinetics, Incorporated
    Inventors: Xiangping Qian, Andrew I. McDonald, Han-Jie Zhou, Luke W. Ashcraft, Bing Yao, Hong Jiang, Jennifer Kuo Chen Huang, Jianchao Wang, David J. Morgans, Jr., Bradley P. Morgan, Gustave Bergnes, Dashyant Dhanak, Steven D. Knight, Nicholas D. Adams, Cynthia A. Parrish, Kevin Duffy, Duke Fitch, Rosanna Tedesco
  • Compounds, compositions and methods
    Patent number: 8119678
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: February 21, 2012
    Assignee: Cytokinetics, Incorporated
    Inventors: Andrew McDonald, Gustave Bergnes, Bainian Feng, David J. Morgans, Jr., Steven David Knight, Kenneth A. Newlander, Dashyant Dhanak, Christopher A. Brook
  • Ureas and their use in the treatment of heart failure
    Patent number: 8110595
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: June 16, 2005
    Date of Patent: February 7, 2012
    Assignee: Cytokinetics, Inc.
    Inventors: Bradley Paul Morgan, Alex Muci, Pu-Ping Lu, Erica Anne Kraynack, Todd Tochimoto, David J. Morgans, Jr.
  • Heterocyclic sulfonamides
    Patent number: 8101620
    Abstract: Provided is a compound of the following formula: wherein: R3 is an aryl or heteroaryl group, which is optionally substituted with a halogen, lower alkoxy, aryl or heteroaryl group; R4 is halogen; R5 is hydrogen, halogen, hydroxy, or lower alkyl; R6 and R7 are independently selected from hydrogen, halogen, hydroxy, and lower alkyl; and R8 is hydrogen, alkyl, halogen, hydroxy, alkoxy, alkylenedioxy, carboxy, acyloxy, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbonylamino, aminocarbonyl, aminocarbonylamino, cyano, acyl, oxo, nitro, amino, sulfanyl, sulfinyl, sulfonyl, aminosulfonyl, amidino, phenyl, benzyl, heteroaryl, heterocyclyl, aryloxy, arallkoxy, heteroaryloxy, or heteroaralkoxy, wherein the amino(s) in the alkoxycarbonylamino, alkylcarbonylamino, aminocarbonyl, aminocarbonylamino, amino, or aminosulfonyl is optionally substituted with alkyl; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: January 24, 2012
    Assignee: Cytokinetics, Inc.
    Inventors: Bradley Paul Morgan, Fady Malik, Erica Anne Kraynack, Alexander Ramon Muci, Xiangping Qian, David J. Morgans, Jr.
  • Certain chemical entities, compositions, and methods
    Patent number: 8088793
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: January 3, 2012
    Assignee: Cytokinetics, Inc.
    Inventors: Xiangping Qian, Chihyuan (Grace) Chuang, Pu-Ping Lu, Bing Yao, Qing (Kevin) Lu, Hong Jiang, Wenyue Wang, Bradley P. Morgan, David J. Morgans, Jr.
  • Certain chemical entities, compositions, and methods
    Patent number: 8071625
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: December 6, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Xiangping Qian, Pu-Ping Lu, Chihyuan (Grace) Chuang, Bradley P. Morgan, David J. Morgans, Jr.
  • Certain chemical entities, compositions, and methods
    Patent number: 8063082
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: November 22, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Xiangping Qian, Jeffrey T. Finer, Pu-Ping Lu, Chihyuan (Grace) Chuang, Bradley P. Morgan, David J. Morgans, Jr.
  • Methods and compostions utilizing quinazolinones
    Patent number: 8008311
    Abstract: Quinazolinones of formulae (a, b, c and d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: August 30, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Bainian Feng, Whitney W. Smith, John C. Chabala
  • Certain chemical entities, compositions and methods
    Patent number: 7998976
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: August 16, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Alex R. Muci, Gustave Bergnes, Bradley P. Morgan
  • Certain chemical entities, compositions, and methods
    Patent number: 7989469
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle wasting, claudication, frailty, metabolic syndrome, muscle atrophy associated with disuse, and muscle fatigue, and other indications.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: August 2, 2011
    Assignee: Cytokinetics, Incorporated
    Inventors: Zhe Yang, Scott Collibee, Alex R. Muci, Jianchao Wang, Luke W. Ashcraft, Jeff Gardina, Brian Stoltz, Gustave Bergnes, Bradley P. Morgan
  • Compounds, compositions and methods
    Patent number: 7989455
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: August 2, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Bradley P. Morgan, David J. Morgans, Jr., Alex Muci, Pu-Ping Lu, Erica A. Kraynack, Todd Tochimoto
  • Certain 1H-imidazo[4,5-B]pyrazin-2(3H)-ones and 1H-imidazo[4,5-B]pyrazin-2-ols, compositions thereof, and methods for their use
    Patent number: 7956056
    Abstract: Provided is at least one chemical entity chosen from compounds of Formula I and Formula II: and pharmaceutically acceptable salts thereof, compositions thereof, and methods for their use in modulating one or more of skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, skeletal muscle, and skeletal sarcomere.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: June 7, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, Jr.
  • Certain chemical entities, compositions, and methods
    Patent number: 7939534
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: May 10, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Pu-Ping Lu, Xiangping Qian, Chihyuan (Grace) Chuang, Bradley P. Morgan, David J. Morgans, Jr.
  • Certain chemical entities, compositions, and methods
    Patent number: 7939548
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: May 10, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Pu-Ping Lu, Xiangping Qian, Chihyuan (Grace) Chuang, Bradley P. Morgan, David J. Morgans, Jr.
  • Certain chemical entities, compositions, and methods
    Patent number: 7932270
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: April 26, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Pu-Ping Lu, Xiangping Qian, Jeffrey T. Finer, Chihyuan (Grace) Chuang, Bradley P. Morgan, David J. Morgans, Jr.