Patents Assigned to Cytonix Corporation
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Patent number: 7579056Abstract: Hydrophobic coating compositions are provided as are processes to coat articles with the compositions. Extremely hydrophobic coatings are provided by the compositions. Durable, weatherable and scratch-resistant coatings are provided by compositions comprising a fluorinated component and an adhesion promoter compound. The adhesion promoter compound can include an alkoxy group, a furfuryl-containing ring structure, and a reactive group.Type: GrantFiled: December 29, 2006Date of Patent: August 25, 2009Assignee: Cytonix CorporationInventor: James F. Brown
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Patent number: 7459315Abstract: A miniaturized assembly is provided whereby a fluid sample can be divided into a plurality of sample portions in retaining wells and the sample fluid can be displaced from open ends of the wells while simultaneously being sealed in the wells. A method of dividing a fluid sample using the assembly is also provided.Type: GrantFiled: April 25, 2002Date of Patent: December 2, 2008Assignees: Cytonix Corporation, The United States of America as represented by the Secretary of Health and Human ServicesInventor: James F Brown
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Publication number: 20070281110Abstract: Hydrophobic coating compositions are provided as are processes to coat articles with the compositions. Extremely hydrophobic coatings are provided by the compositions. Durable, weatherable and scratch-resistant coatings are provided by compositions comprising a fluorinated component and an adhesion promoter compound. The adhesion promoter compound can include an alkoxy group, a furfuryl-containing ring structure, and a reactive group.Type: ApplicationFiled: August 9, 2007Publication date: December 6, 2007Applicant: Cytonix CorporationInventor: James Brown
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Patent number: 7268179Abstract: Hydrophobic coating compositions are provided as are processes to coat articles with the compositions. Extremely hydrophobic coatings are provided by the compositions. Durable, weatherable and scratch-resistant coatings are provided by compositions comprising a fluorinated component and an adhesion promoter compound. The adhesion promoter compound can include an alkoxy group, a furfuryl-containing ring structure, and a reactive group.Type: GrantFiled: September 30, 2003Date of Patent: September 11, 2007Assignee: Cytonix CorporationInventor: James F. Brown
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Publication number: 20070110907Abstract: Hydrophobic coating compositions are provided as are processes to coat articles with the compositions. Extremely hydrophobic coatings are provided by the compositions. Durable, weatherable and scratch-resistant coatings are provided by compositions comprising a fluorinated component and an adhesion promoter compound. The adhesion promoter compound can include an alkoxy group, a furfuryl-containing ring structure, and a reactive group.Type: ApplicationFiled: December 29, 2006Publication date: May 17, 2007Applicant: Cytonix CorporationInventor: James Brown
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Publication number: 20060216426Abstract: A system and method is shown for coating an article, including a chamber that can be at least partially open to surrounding air to allow free flow of air through the chamber and recovery of vapor produced during a coating operation within the chamber. The chamber can include a support surface that is adapted to support the article during a coating process, and a coating device within the chamber can be adapted to selectively apply a coating of a fluorocarbon in a fluorinated solvent to at least a potion of an article supported on the support surface.Type: ApplicationFiled: March 22, 2005Publication date: September 28, 2006Applicant: Cytonix CorporationInventor: James Brown
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Publication number: 20050003203Abstract: Hydrophobic coating compositions are provided as are processes to coat articles with the compositions. Extremely hydrophobic coatings are provided by the compositions. Durable, weatherable and scratch-resistant coatings are provided by compositions comprising a trifluoromethyl-containing component and a hardenable material. Weatherable coatings are also provided by compositions comprising a mobile non-volatile fluorinated component and a hardenable material. Processes are also provided for forming hydrophobic coatings on articles.Type: ApplicationFiled: July 26, 2004Publication date: January 6, 2005Applicant: Cytonix CorporationInventor: James Brown
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Publication number: 20040171055Abstract: A miniaturized assembly is provided whereby a fluid sample can be divided into a plurality of sample portions in retaining wells and the sample fluid can be displaced from open ends of the wells while simultaneously being sealed in the wells. A method of dividing a fluid sample using the assembly is also provided.Type: ApplicationFiled: March 11, 2004Publication date: September 2, 2004Applicant: Cytonix CorporationInventor: James F. Brown
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Patent number: 6767587Abstract: Hydrophobic coating compositions are provided as are processes to coat articles with the compositions. Extremely hydrophobic coatings are provided by the compositions. Durable, weatherable and scratch-resistant coatings are provided by compositions comprising a trifluoromethyl-containing component and a hardenable material. Weatherable coatings are also provided by compositions comprising a mobile non-volatile fluorinated component and a hardenable material. Processes are also provided for forming hydrophobic coatings on articles.Type: GrantFiled: October 17, 2002Date of Patent: July 27, 2004Assignee: Cytonix CorporationInventor: James F. Brown
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Patent number: 6663941Abstract: Hydrophobic coating compositions are provided as are processes to coat articles with the compositions. Extremely hydrophobic coatings are provided by the compositions. Durable, weatherable and scratch-resistant coatings are provided by compositions comprising a trifluoromethyl-containing component and a hardenable material. Processes are also provided for forming hydrophobic coatings on articles without any substantial loss of fluorocarbon solvent used in the coating composition. Articles are coated on a surface thereof with a hydrophobic coating reactant or reaction product which forms a coating having an exposed surface populated with 30% by area or more terminal trifluoromethyl groups.Type: GrantFiled: September 5, 2002Date of Patent: December 16, 2003Assignee: Cytonix CorporationInventors: James F. Brown, Richard A. Schneider
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Patent number: 6495624Abstract: Hydrophobic coating compositions are provided as are processes to coat articles with the compositions. Extremely hydrophobic coatings are provided by the compositions. Durable, weatherable and scratch-resistant coatings are provided by compositions comprising a trifluoromethyl-containing component and a hardenable material. Weatherable coatings are also provided by compositions comprising a mobile non-volatile fluorinated component and a hardenable material. Processes are also provided for forming hydrophobic coatings on articles.Type: GrantFiled: March 30, 2001Date of Patent: December 17, 2002Assignee: Cytonix CorporationInventor: James F. Brown
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Patent number: 6447919Abstract: Hydrophobic coating compositions are provided as are processes to coat articles with the compositions. Extremely hydrophobic coatings are provided by the compositions. Durable, weatherable and scratch-resistant coatings are provided by compositions comprising a trifluoromethyl-containing component and a hardenable material. Processes are also provided for forming hydrophobic coatings on articles without any substantial loss of fluorocarbon solvent used in the coating composition. Articles are coated on a surface thereof with a hydrophobic coating reactant or reaction product which forms a coating having an exposed surface populated with 30% by area or more terminal trifluoromethyl groups.Type: GrantFiled: June 14, 2000Date of Patent: September 10, 2002Assignee: Cytonix CorporationInventors: James F. Brown, Richard A. Schneider
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Patent number: 6391559Abstract: Methods of detecting and quantifying genomic nucliec acid molecule sequences are provided using the simultaneous amplification of a plurality of discrete nanoliter-sized samples. A miniaturized closed assembly is also provided for carrying out amplification of a nucleic acid molecule by polymerase chain reaction in multiple nanoliter-sized samples. Methods of filling miniaturized sample chambers are also provided as are methods for determining the number of template molecules in a sample by conducting replicate nucleic acid sequence amplification reactions on a set of terminally diluted samples and counting the number of positive amplification reactions. The methods can be used to detect a single starting nucleic acid target molecule.Type: GrantFiled: May 2, 2000Date of Patent: May 21, 2002Assignee: Cytonix CorporationInventors: James F. Brown, Jonathan E. Silver, Olga V. Kalinina
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Patent number: 6362246Abstract: A coating formulation for making a porous coating on a laboratory apparatus is provided. The formulation comprises 100 parts by weight hardenable resinous material, and from about 0.1 to about 50 parts by weight blowing agent based on the 100 parts by weight resinous material. The resinous material has a hardening time which is sufficiently short such that gas generated by the blowing agent is entrapped within the resinous material. The coating formulation is hardenable upon application to a surface of a laboratory apparatus to form a porous coating which is used for marking purposes or for the retention of biological samples. Methods of retaining a biological sample on a coated laboratory apparatus having a surface made of the coating formulation are also provided.Type: GrantFiled: January 4, 2001Date of Patent: March 26, 2002Assignee: Cytonix CorporationInventor: James F. Brown
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Patent number: 6265015Abstract: A coating formulation for making a porous coating on a laboratory apparatus is provided. The formulation comprises 100 parts by weight hardenable resinous material, and from about 0.1 to about 50 parts by weight blowing agent based on the 100 parts by weight resinous material. The resinous material has a hardening time which is sufficiently short such that gas generated by the blowing agent is entrapped within the resinous material. The coating formulation is hardenable upon application to a surface of a laboratory apparatus to form a porous coating which is used for marking purposes or for the retention of biological samples. Methods of retaining a biological sample on a coated laboratory apparatus having a surface made of the coating formulation are also provided.Type: GrantFiled: October 14, 1999Date of Patent: July 24, 2001Assignee: Cytonix CorporationInventor: James F. Brown
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Patent number: 6156389Abstract: Hydrophobic coating compositions are provided as are processes to coat articles with the compositions. Extremely hydrophobic coatings are provided by the compositions. Durable, weatherable and scratch-resistant coatings are provided by compositions comprising a trifluoromethyl-containing component and a hardenable material. Processes are also provided for forming hydrophobic coatings on articles without any substantial loss of fluorocarbon solvent used in the coating composition. Articles are coated on a surface thereof with a hydrophobic coating reactant or reaction product which forms a coating having an exposed surface populated with 30% by area or more terminal trifluoromethyl groups.Type: GrantFiled: December 28, 1998Date of Patent: December 5, 2000Assignee: Cytonix CorporationInventors: James F. Brown, Richard A. Schneider
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Patent number: 6143496Abstract: Methods of detecting and quantifying genomic nucleic acid molecule sequences are provided using the simultaneous amplification of a plurality of discrete nanoliter-sized samples. A miniaturized closed assembly is also provided for carrying out amplification of a nucleic acid molecule by polymerase chain reaction in multiple nanoliter-sized samples. Methods of filling miniaturized sample chambers are also provided as are methods for determining the number of template molecules in a sample by conducting replicate nucleic acid sequence amplification reactions on a set of terminally diluted samples and counting the number of positive amplification reactions. The methods can be used to detect a single starting nucleic acid target molecule.Type: GrantFiled: April 17, 1997Date of Patent: November 7, 2000Assignees: Cytonix Corporation, The United States of America as represented by the Department of Health and Human ServicesInventors: James F. Brown, Jonathan E. Silver, Olga V. Kalinina
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Patent number: 6037168Abstract: A microbiological assembly is provided having a resealable seal between a support and a cover. The support has a surface which includes a patterned layer and defines at least one sample retention well. The cover has a surface which contacts a sealant and the sealant is disposed on at least one of the support and the cover. The sealant is adapted to releasably bond and resealably seal the cover to the support. The sealed assembly minimizes contamination and drying of liquid sample retained by the sample retention well. A method of examining a biological culture is also provided and includes the steps of retaining a biological sample within the sample retention well of the assembly, sealing the cover to the support with the sealant between the sealing surface and the support surface, physically separating the cover from the support surface, and then either resealing the cover or sealing a second cover to the support using the same sealant.Type: GrantFiled: December 31, 1997Date of Patent: March 14, 2000Assignee: Cytonix CorporationInventor: James F. Brown
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Patent number: 5989692Abstract: A coating formulation for making a porous coating on a laboratory apparatus is provided. The formulation comprises 100 parts by weight hardenable resinous material, and from about 0.1 to about 50 parts by weight blowing agent based on the 100 parts by weight resinous material. The resinous material has a hardening time which is sufficiently short such that gas generated by the blowing agent is entrapped within the resinous material. The coating formulation is hardenable upon application to a surface of a laboratory apparatus to form a porous coating which is used for marking purposes or for the retention of biological samples. Methods of retaining a biological sample on a coated laboratory apparatus are also provided.Type: GrantFiled: September 2, 1997Date of Patent: November 23, 1999Assignee: Cytonix CorporationInventor: James F. Brown
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Patent number: 5853894Abstract: Laboratory vessels are coated on an operational surface thereof with a hydrophobic coating polymer or reactive monomer to form a coating having an exposed surface populated with 30% by area or more terminal trifluoromethyl groups. Laboratory vessels coated with such coating solutions are provided having extremely low surface energies and high resistance to solvent attack. Methods of forming hydrophobic coatings on laboratory vessels are also provided and include methods of forming exposed coating surfaces having populations of from about 30% by area to 100% by area trifluoromethyl groups. The hydrophobic coatings may be prepared from solutions, suspensions or powdered materials containing a fluoroalkyl ethylenically unsaturated monomer substantially free of any crosslinking, having from about 3 to about 20 carbon atoms, and containing at least one terminal trifluoromethyl group, or containing a polymerization product of such a monomer.Type: GrantFiled: February 3, 1997Date of Patent: December 29, 1998Assignee: Cytonix CorporationInventor: James F. Brown