Abstract: The invention involves functionalizing polymeric beads, such as DVB beads, to add an epoxide or aldehyde group. The resulting beads are useful in various applications.
Type:
Grant
Filed:
May 10, 2019
Date of Patent:
January 12, 2021
Assignee:
CYTOSORBENTS, INC.
Inventors:
Thomas Golobish, Tamaz Guliashvili, Vincent Capponi
Abstract: A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one crosslinking agent and at least one dispersing agent, and the polymer has a plurality of pores with diameters in the range from about 17 to about 40,000 Angstroms.
Type:
Grant
Filed:
May 22, 2012
Date of Patent:
March 28, 2017
Assignee:
Cytosorbent, Inc.
Inventors:
Wei-Tai Young, Robert L. Albright, Thomas D. Golobish, Vincent Capponi, Philip Chan
Abstract: Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce or have the potential for inducing abnormal production of pro-inflammatory or anti-inflammatory stimulators or mediators. The devices, systems, and methods serve to prevent, control, reduce, or alleviate the severity of the inflammatory response and disease states that are associated with abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators.
Type:
Grant
Filed:
December 2, 2010
Date of Patent:
January 8, 2013
Assignees:
Cytosorbents, Inc.
Inventors:
James A Brady, James F Winchester, Vadim Davankov, Maria Tsvurupa, Ludmila Pavlova, Frank M Norris, Peter J Quartararo, Jr., Jamie A Salsberg
Abstract: Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce or have the potential for inducing abnormal production of pro-inflammatory or anti-inflammatory stimulators or mediators. The devices, systems, and methods serve to prevent, control, reduce, or alleviate the severity of the inflammatory response and disease states that are associated with abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators.
Type:
Grant
Filed:
May 20, 2010
Date of Patent:
December 18, 2012
Assignees:
Cytosorbents, Inc.
Inventors:
James A Brady, James F Winchester, Vadim Davankov, Maria Tsyurupa, Ludmila Pavlova, Frank M Norris, Peter Quartararo, Jr., Jamie A Salsberg
Abstract: Devices, systems, and methods reduce levels of proinflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among proinflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce or have the potential for inducing abnormal production of proinflammatory or anti-inflammatory stimulators or mediators. The devices, systems, and methods serve to prevent, control, reduce, or alleviate the severity of the inflammatory response and disease states that are associated with abnormal levels of or unregulated or excessive interaction among proinflammatory or anti-inflammatory stimulators or mediators.
Type:
Grant
Filed:
September 9, 2010
Date of Patent:
December 11, 2012
Assignees:
Cytosorbents, Inc.
Inventors:
James A Brady, James F Winchester, Vadim Davankov, Maria Tsvurupa, Ludmila Pavlova, Frank M Norris, Peter J Quartararo, Jr., Jamie A Salsberg
Abstract: A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one polymer with a plurality of pores, and the polymer has at least one transport pore with a diameter from about 250 Angstroms to about 2000 Angstroms, and the polymer has a transport pore volume greater than about 1.8% to about 78% of a capacity pore of volume of the polymer.
Type:
Grant
Filed:
September 9, 2010
Date of Patent:
July 3, 2012
Assignee:
Cytosorbents, Inc.
Inventors:
Wei-Tai Young, Robert L. Albright, Thomas D. Golobish, Vincent Capponi, Philip Chan
Abstract: Size-selective hemocompatible porous polymeric adsorbents are provided with a pore structure capable of excluding molecules larger than 50,000 Daltons, but with a pore system that allows good ingress and egress of molecules smaller than 35,000 Daltons. The pore system in these porous polymeric adsorbents is controlled by the method of synthesis so that 98% of the total pore volume is located in pores smaller than 300 Angstroms (?) in diameter with a working pore size range within 100 to 300 ? in diameter. The porous polymeric adsorbents of this invention are very selective for extracting midsize proteins, such as cytokines and ?2-microglobulin, from blood and other physiologic fluids while keeping the components required for good health such as cells, platelets, albumin, hemoglobin, fibrinogen, and other serum proteins intact.
Type:
Grant
Filed:
November 20, 2006
Date of Patent:
January 25, 2011
Assignee:
Cytosorbents, Inc.
Inventors:
Wei-Tai Young, Robert L. Albright, Thomas D. Golobish
Abstract: Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce or have the potential for inducing abnormal production of pro-inflammatory or anti-inflammatory stimulators or mediators. The devices, systems, and methods serve to prevent, control, reduce, or alleviate the severity of the inflammatory response and disease states that are associated with abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators.
Type:
Grant
Filed:
December 18, 2007
Date of Patent:
December 7, 2010
Assignees:
Cytosorbents, Inc.
Inventors:
James A Brady, James F Winchester, Vadim Davankov, Maria Tsyurupa, Ludmila Pavlova, Frank M Norris, Peter J Quartararo, Jr., Jamie A Salsberg