Abstract: Connector assemblies and methods of replacing components in an extra-corporeal circuit (ECC) system are disclosed. A connector assembly for use in an ECC system includes a tubular body having an inner surface defining a lumen extending through the tubular body with the lumen extending along a longitudinal axis, a first connection interface in fluid communication with the lumen, a second connection interface in fluid communication with the lumen, and a plurality of closure mechanisms, each closure mechanism being configured to occlude the lumen.
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
Type:
Grant
Filed:
July 12, 2021
Date of Patent:
November 28, 2023
Assignee:
CytoSorbents Corporation
Inventors:
Tamaz Guliashvili, Thomas Golobish, Maryann Gruda, Pamela O'Sullivan, Andrew Scheirer, Vincent Capponi, Phillip Chan, Wei-Tai Young
Abstract: The invention concerns methods of treating blood, blood product, or physiologic fluid to provide at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; said method comprising contacting said blood, blood product or physiologic fluid with a sorbent, said sorbent being primarily in a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of at least one of (1) zwitterionic moieties and (2) oligo(ethylene glycol) moieties attached to the surface of said cross-linked polymeric material.
Type:
Grant
Filed:
March 31, 2014
Date of Patent:
September 12, 2023
Assignee:
CytoSorbents Corporation
Inventors:
Thomas D. Golobish, Vincent J. Capponi, David R. Clay
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
Type:
Grant
Filed:
June 8, 2021
Date of Patent:
August 15, 2023
Assignee:
CytoSorbents Corporation
Inventors:
Thomas Golobish, Maryann Gruda, Tamaz Guliashvili, Pamela O'Sullivan, Andrew Scheirer, Vi Dan, Wei-Tai Young, Vincent Capponi, Phillip Chan
Abstract: Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 ? to 40,000 ? with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50 ? to 40,000 ? with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.
Type:
Grant
Filed:
April 26, 2017
Date of Patent:
March 14, 2023
Assignee:
CytoSorbents Corporation
Inventors:
Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.
Type:
Grant
Filed:
March 22, 2018
Date of Patent:
December 21, 2021
Assignee:
CYTOSORBENTS CORPORATION
Inventors:
Wei-Tai Young, Tamaz Guliashvili, Andrew Scheirer, Josh Vichare, Timothy Kovacs, Maryann Gruda, Thomas Golobish, Vincent Capponi, Phillip Chan
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
Type:
Grant
Filed:
May 18, 2017
Date of Patent:
July 20, 2021
Assignee:
CYTOSORBENTS CORPORATION
Inventors:
Tamaz Guliashvili, Thomas Golobish, Maryann Gruda, Pamela O'Sullivan, Andrew Scheirer, Vincent Capponi, Phillip Chan, Wei-Tai Young
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
Type:
Grant
Filed:
June 3, 2016
Date of Patent:
July 13, 2021
Assignee:
CYTOSORBENTS CORPORATION
Inventors:
Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
Type:
Grant
Filed:
October 21, 2016
Date of Patent:
June 22, 2021
Assignee:
CytoSorbents Corporation
Inventors:
Thomas Golobish, Maryann Gruda, Tamaz Guliashvili, Pamela O'Sullivan, Andrew Scheirer, Vi Dan, Wei-Tai Young, Vincent Capponi, Phillip Chan
Abstract: The invention concerns methods of removing undesirable molecules from the blood or physiologic fluid; said method comprising contacting said blood or physiologic fluid with a sorbent, said sorbent comprising a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of ligands attached to the surface of said cross-linked polymeric material, comprising (i) zwitterionic moieties, (ii) oligo(ethylene glycol) moieties or (iii) mixtures thereof; said contacting comprising said sorbent sorbing a plurality of said undesirable molecules when said sorbent is administered within a patient's body.
Type:
Grant
Filed:
April 17, 2020
Date of Patent:
June 1, 2021
Assignee:
CYTOSORBENTS CORPORATION
Inventors:
Thomas D. Golobish, Vincent J. Capponi, David R. Clay
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
Type:
Grant
Filed:
June 26, 2018
Date of Patent:
April 6, 2021
Assignee:
CYTOSORBENTS CORPORATION
Inventors:
Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Abstract: The present invention concerns methods of administering a therapeutically effective dose of a sorbent for an inflammatory mediator to a patient where the inflammatory mediator is one or more of enzymes, cytokines, prostaglandins, eicosanoids, leukotrienes, kinins, complement, coagulation factors, endotoxins, enterotoxins, lipopolysaccharide, cell fragments, bile salts, fatty acids, phospholipids, interferon and immunomodulatory antibodies, biologics or drugs.
Type:
Grant
Filed:
May 29, 2019
Date of Patent:
March 16, 2021
Assignee:
CYTOSORBENTS CORPORATION
Inventors:
Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Abstract: Connector assemblies and methods of replacing components in an extra-corporeal circuit (ECC) system are disclosed. A connector assembly for use in an ECC system includes a tubular body having an inner surface defining a lumen extending through the tubular body with the lumen extending along a longitudinal axis, a first connection interface in fluid communication with the lumen, second connection interface in fluid communication with the lumen, and a plurality of closure mechanisms, each closure mechanism being configured to occlude the lumen.
Abstract: The invention concerns methods of treating stored blood and blood products maximizing shelf life and/or minimizing transfusion related complications such as nonĀ¬ hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood and blood products milieu through use of a sorbent.
Type:
Grant
Filed:
August 10, 2012
Date of Patent:
October 1, 2019
Assignee:
CytoSorbents Corporation
Inventors:
Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
Type:
Grant
Filed:
February 2, 2018
Date of Patent:
June 11, 2019
Assignee:
Cytosorbents Corporation
Inventors:
Humayra Begum Ali, Thomas D. Golobish, Vincent J. Capponi, Phillip P. Chan, Wei Tai Young, Andrew Robert Scheirer
Abstract: The invention concerns methods of treating blood, blood products or physiologic fluid to maximize shelf life and/or minimizing transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood, blood product or physiologic fluid milieu through use of a sorbent.
Type:
Grant
Filed:
January 5, 2012
Date of Patent:
September 4, 2018
Assignee:
CytoSorbents Corporation
Inventors:
Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
Type:
Grant
Filed:
June 28, 2017
Date of Patent:
July 31, 2018
Assignee:
CYTOSORBENTS CORPORATION
Inventors:
Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
Type:
Grant
Filed:
October 2, 2015
Date of Patent:
April 3, 2018
Assignee:
CytoSorbents Corporation
Inventors:
Humayra Begum Ali, Thomas D. Golobish, Vincent J. Capponi, Phillip P. Chan, Wei-Tai Young, Andrew Robert Scheirer
Abstract: The invention concerns polymer systems comprising at least one polymer with a plurality of pores where the polymer is initially functionalized on substantially all surfaces followed by a stepwise surface specific functionalization such that a different functional group resides on the external or internal pore surface of the bead. The invention also concerns use of such polymer systems in blood, blood product, or physiologic fluid purification.
Type:
Grant
Filed:
January 6, 2012
Date of Patent:
April 3, 2018
Assignee:
CytoSorbents Corporation
Inventors:
Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
Type:
Application
Filed:
October 2, 2015
Publication date:
August 3, 2017
Applicant:
Cytosorbents Corporation
Inventors:
Humayra Begum ALI, Thomas D. GOLOBISH, Vincent J. CAPPONI, Phillip P. CHAN, Wei-Tai YOUNG, Andrew Robert SCHEIRER