Abstract: The present embodiments relate to nucleic acid probes for detecting PTEN, ZBTB20-LSAMP, and LSAMP mutations. The nucleic acid probes are particularly useful for detecting deletions in the PTEN and LSAMP genes as diagnostics for prostate cancer, especially aggressive forms of prostate cancer for which treatment is indicated. The probes are particularly useful for in situ hybridization to chromosomes present in tissue samples.

Abstract: A detectably labeled DNA FISH probe comprises detectably-labeled nucleic acid molecules from the 8p11.23 chromosomal region and from the 2q35 chromosomal region. The probe is a FISH probe capable of detecting a fusion between the FGFR1 and FN1 genes. A patient having a disease associated with a FN1-FGFR1 gene fusion may be treated by: detecting translocation of a portion of the FGFR1 gene to the FN1 gene using chromosomal FISH probes, and treating a patient with said translocation and gene fusion with 1) a drug which inhibits FGF 2) a drug which inhibits FGFR1, and/or a 3) drug which targets a signaling pathway associated with FGFR1.