Patents Assigned to Cytovation AS
  • Oligopeptide compounds and uses thereof
    Patent number: 9353156
    Abstract: The present invention relates to novel agents, pharmaceutical compositions containing them, and their use in therapy, particularly anti-microbial and anti-cancer therapy. In particular, the present invention relates to novel peptide-based compounds based on SEQ ID NO: 40 which have surprisingly been shown to have inhibitory effects on the growth and/or viability of cells, particularly bacterial and cancer cells. Also provided are therapeutic and non-therapeutic methods which include the use of peptides of the invention.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: May 31, 2016
    Assignee: Cytovation AS
    Inventor: Lars Prestegarden
  • Oligopeptide compounds and uses thereof
    Patent number: 8754042
    Abstract: The present invention relates to novel agents, pharmaceutical compositions containing them, and their use in therapy, particularly anti-microbial and anti-cancer therapy. In particular, the present invention relates to novel peptide-based compounds based on SEQ ID NO:40 which have surprisingly been shown to have inhibitory effects on the growth and/or viability of cells, particularly bacterial and cancer cells. Also provided are therapeutic and non-therapeutic methods which comprise the use of peptides of the invention.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: June 17, 2014
    Assignee: Cytovation AS
    Inventor: Lars Prestegarden
  • Method of Generating and Isolating Tumour Cells
    Publication number: 20070269845
    Abstract: The invention provides a method of generating and isolating cells of a defined tumour phenotype being invasive and angiogenesis-independent (phenotype I), from a tumour sample, said method comprising the steps of culturing tumour cells of said tumour sample for up to nine days in order to establish multicellular spheroids, and implanting said multicellular spheroids thus obtained into an immunodeficient animal. It further provides methods for generating and isolating tumour cells of phenotype II (invasive and angiogenesis independent) which involves the generation of cells of phenotype I and serial passaging of the cells in animals. Furthermore, by modifying the amount of time the spheroids are cultured prior to implantation into an animal, cells of phenotype III (non-invasive, angiogenesis dependent) may be generated and isolated. The present invention further provides animal models of all phenotype tumours, isolated tumour cells of the defined phenotypes and uses thereof.
    Type: Application
    Filed: April 29, 2004
    Publication date: November 22, 2007
    Applicant: Cytovation AS
    Inventor: Rolf Bjerkvig