Patents Assigned to Cytran, Inc.
  • Pharmaceutical dipeptide compositions and methods of use thereof: immunostimulants
    Patent number: 6777195
    Abstract: Methods of treatment of subjects for decreasing cell mediated autoimmunity or humoral autoimmunity by administering an R′-Glu-Trp-R″ pharmaceutical preparation useful in subjects having autoimmune diseases.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: August 17, 2004
    Assignee: Cytran, Inc.
    Inventors: Andrei L. Kozhemyakin, Nickolai V. Sinackevich, Sergey V. Seryi, Alexei M. Rakhilov, Vyacheslav G. Morozov, Vladimir Kh. Khavinson
  • Pharmaceutical dipeptide compositions and methods of use thereof: immunostimulants
    Publication number: 20020177226
    Abstract: Methods of treatment of subjects for decreasing cell mediated autoimmunity or humoral autoimmunity by administering an R′-Glu-Trp-R″ pharmaceutical preparation useful in subjects having autoimmune diseases.
    Type: Application
    Filed: February 14, 2002
    Publication date: November 28, 2002
    Applicant: Cytran, Inc.
    Inventors: Andrei L. Kozhemyakin, Nickolai V. Sinackevich, Sergey V. Seryi, Alexei M. Rakhilov, Vyacheslav G. Morozov, Vladimir Khavinson, Lawrence R. Green
  • Method of treating complications in immunodepressed states resulting from HIV infection
    Patent number: 6368788
    Abstract: Methods of treatment of subjects for decreasing cell mediated autoimmunity or humoral autoimmunity by administering an R′-Glu-Trp-R″ pharmaceutical preparation useful in subjects having autoimmune diseases.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: April 9, 2002
    Assignee: Cytran, Inc.
    Inventors: Andrei L. Kozhemyakin, Nickolai V. Sinackevich, Sergey V. Seryi, Alexei M. Rakhilov, Vyacheslav G. Morozov, Vladimir Kh. Khavinson
  • Pharmaceutical dipeptide compositions and methods of use thereof
    Patent number: 6139862
    Abstract: Methods are provided for the therapy of immunodeficient, immunodepressed or hyperactive immune states and for the prevention and treatment of opportunistic infections in such states comprising administering to a subject a pharmaceutically acceptable composition comprising as an active ingredient the dipeptide L-Ile-L-Trp, linear and cyclic monomers and polymers thereof, and/or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: April 8, 1998
    Date of Patent: October 31, 2000
    Assignee: Cytran, Inc.
    Inventors: Vladimir Khatskelevich Khavinson, Sergy Vladimirovich Sery, Vyacheslav Grigorievich Morozov
  • Pharmaceutical preparation for the therapy of immune deficiency conditions
    Patent number: 6136788
    Abstract: This invention is directed to water soluble salts of L-Glu-L-Trp.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: October 24, 2000
    Assignee: Cytran, Inc.
    Inventors: Vyacheslav Grigorievich Morozov, Vladimir Khatskelevich Khavinson
  • Immunomodulating peptides and methods of use
    Patent number: 6100380
    Abstract: This invention provides peptides of the formula R'-Glx-Glx-Lys-R" in which Glx is Glu or Gln. In particular, this invention provides the peptides Thr-Ala-Glu-Glu-Lys and Thr-Pro-Glu-Glu-Lys. This invention also provides pharmaceutical compositions comprising these peptides. The peptides of this invention are useful for immunomodulation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 8, 2000
    Assignee: Cytran, Inc.
    Inventors: Lawrence R. Green, Nickolai V. Sinakevich, Vadim T. Ivanov, Inessa I. Mikhalyova, Boris V. Vaskovsky, Alexander N. Mikhaltsov, Vyacheslav G. Morozov, Vladimir K. Khavinson
  • Pharmaceutical angiostatic dipeptide compositions and methods of use thereof
    Patent number: 6096713
    Abstract: Disclosed are methods of inhibiting neovascularization in a subject by administering to the subject a pharmaceutical preparation of R'-Glu-Trp-R".
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: August 1, 2000
    Assignee: Cytran, Inc.
    Inventors: Lawrence R. Green, John W. Blasecki
  • Immunomodulating peptides and methods of use
    Patent number: 6066622
    Abstract: This invention provides methods of modulating the immune system by administering peptides of the formula R'-Glx-Glx-Lys-R" (SEQ ID NO:1) in which Glx is Glu or Gln. In particular, this invention provides the use of peptides Thr-Ala-Glu-Glu-Lys (SEQ ID NO:34) and Thr-Pro-Glu-Glu-Lys (SEQ ID NO:33).
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: May 23, 2000
    Assignee: Cytran, Inc.
    Inventors: Lawrence R. Green, Nicolay V. Sinackevich, Vadim T. Ivanov, Inessa I. Mikhalyova, Boris V. Vaskovsky, Alexander N. Mikhaltsov, Vladimir K. Khavinson, Vyacheslav G. Morozov
  • Analogs of L-Glu-L-Trp having pharmacological activity
    Patent number: 6060452
    Abstract: This invention provides analogs of L-Glu-L-Trp and methods of using them for immunomodulation and treatment of pathological neovascular conditions. The analogs include the substitution of a carbon atom for a nitrogen atom in the indole ring of tryptophan.
    Type: Grant
    Filed: April 3, 1998
    Date of Patent: May 9, 2000
    Assignee: Cytran, Inc.
    Inventors: Lawrence R. Green, Nickolay V. Sinackevich
  • Peptides having potassium channel opener activity
    Patent number: 5972894
    Abstract: This invention concerns methods for prophylactic and therapeutic treatment of diseases responsive to the opening of potassium channels, peptides having potassium channel opener activities, and pharmaceutical compositions and kits comprising such peptides.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: October 26, 1999
    Assignee: Cytran, Inc.
    Inventors: Nickolai V. Sinackevich, Alexi M. Rakhilov, Sergei V. Maslennikov, Lawrence R. Green
  • Pharmaceutical angiostatic dipeptide compositions and method of use thereof
    Patent number: 5902790
    Abstract: Disclosed are methods of inhibiting neovascularization in a subject by administering to the subject a pharmaceutical preparation of R'-Glu-Trp-R".
    Type: Grant
    Filed: March 13, 1996
    Date of Patent: May 11, 1999
    Assignee: Cytran, Inc.
    Inventors: Lawrence R. Green, John W. Blasecki
  • Pharmaceutical dipeptide compositions and methods of use thereof: immunodepressants
    Patent number: 5811399
    Abstract: Methods of treatment of subjects for decreasing cell mediated autoimmunity or humoral autoimmunity by administering an R'-Glu-Trp-R" pharmaceutical preparation useful in subjects having autoimmune diseases.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: September 22, 1998
    Assignee: Cytran, Inc.
    Inventors: Vladimir Kh. Khavinson, Vyacheslav G. Morozov
  • Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity
    Patent number: 5770576
    Abstract: Methods of treatment of subjects with systemic toxicity by administering an R'-Glu-Trp-R" pharmaceutical preparation.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: June 23, 1998
    Assignee: Cytran, Inc.
    Inventors: Vyacheslav G. Morozov, Vladimir Kh. Khavinson