Abstract: This invention provides analogs of L-Glu-L-Trp and methods of using them for immunomodulation and treatment of pathological neovascular conditions. The analogs include the substitution of a carbon atom for a nitrogen atom in the indole ring of tryptophan.
Type:
Application
Filed:
May 14, 2002
Publication date:
September 19, 2002
Applicant:
Cytran Incorporated
Inventors:
Lawrence R. Green, Nickolay V. Sinackevich
Abstract: Methods are provided for the therapy of immunodeficient, immunodepressed or hyperactive immune states and for the treatment of opportunistic infections in such states comprising administering to a subject a pharmaceutically acceptable composition comprising as an active ingredient the dipeptide L-Ile-L-Trp, linear and cyclic monomers and polymers thereof, and/or pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
March 31, 1995
Date of Patent:
August 4, 1998
Assignee:
Cytran, Incorporated
Inventors:
Vladimir Khatskelevich Khavinson, Sergy Vladimirovich Sery, Vyacheslav Grigorievich Morozov