Abstract: Pharmaceutical compositions and methods of inhibiting the enzyme elastase and increasing the biological half-life and/or potency in terms of inhibitory activity of the enzyme elastase of peptide compounds is achieved by use of a polymer of the formula P--(L--R).sub.q wherein P is a polymer containing at least one unit of the formula (A.sub.n B.sub.n) wherein A.sub.n B.sub.n is substantially nonbiodegradable, and has an average molecular weight of about 1,000 to 5,000 daltons, L is a covalent bond or a linker group and R is a peptide.
Type:
Grant
Filed:
March 25, 1992
Date of Patent:
November 10, 1992
Assignees:
Board of Trustees of the University of Kentucky, Czechoslovak Academy of Sciences
Inventors:
George A. Digenis, Bushra J. Agha, William R. Banks, Frantisek Rypacke