Abstract: The invention relates to a composite polymeric material suitable for biological and medical applications and to the method for preparation thereof. The composite material consists of 1-99 wt. % of hydrophilic polymer or copolymer based on methacrylic or acrylic esters, 1-99 wt. % of fibrillar collagen, and up to 2.5 wt. % of a crosslinking agent, based on both polymeric components. The composite material may further comprise biologically active compounds and other auxiliary materials, as fillers and/or plasticizers. The composite material is prepared by dispersing the fibrillar collagen in a solution or a highly swollen dispersion of the synthetic hydrophilic polymer or copolymer in a lytropic agent and the subsequent removal of the lyotropic agent, thus forming a matrix of the synthetic polymer or copolymer penetrated by fibrillar collagen or vice versa. The composite material may be applied on a solid support or reinforced with glass, plastics, cellulose, or metallic materials.
Type:
Grant
Filed:
November 18, 1983
Date of Patent:
January 7, 1986
Assignee:
Czechoslovenska akademie ved of Praha
Inventors:
Miroslav Stol, Miroslav Tolar, Milan Adam, Pavel Cefelin, Jaroslav Kalal
Abstract: The invention relates to a method for preparation of hydrophilic anion exchangers from gels based on crosslinked copolymers of hydroxyalkyl acrylates and methacrylates, oligo- and polyglycol monoacrylates and monomethacrylates, hydroxyalkylacrylamides or hydroxyalkylmethacrylamides with crosslinking comonomers containing 2 or more acrylcyl or methacryloyl groups in the molecule, as alkylene, oligo- and polyglycol diacrylates and dimethacrylates or divinylbenzene, which gels may have the homogeneous, heterogeneous or macroporous character.
Type:
Grant
Filed:
February 7, 1975
Date of Patent:
July 18, 1978
Assignee:
Czechoslovenska akademie ved
Inventors:
Petr Strop, Jiri Coupek, Otakar Mikes, Jiri Hradil
Abstract: Process for producing polymers comprising connecting polymeric molecules which contain chemically bound tertiary amino groups in the chain by oxidizing the macromolecules to be connected with air or an oxidizing agent such as compounds containing a peroxidic bond, for example, inorganic and organic peroxides, or organic anhydrides. It is possible to connect chains of identical or different types and in this way increase the molecular weight, produce block copolymers, cure films of varnishes and perform vulcanization and the like at ambient temperature.
Type:
Grant
Filed:
August 17, 1972
Date of Patent:
August 16, 1977
Assignee:
Czechoslovenska akademie ved
Inventors:
Frantisek Hrabak, Vlasta Hynkova, Jan Lokaj