Abstract: Disclosed is a method of predicting a prognosis of a patient with adenocarcinoma using image features. The method of predicting a prognosis according to an embodiment of the present invention includes receiving an image including a lesion region of a patient, preprocessing the received image, segmenting the lesion region in the preprocessed image and calculating at least one of biomarkers indicating an intensity value and a texture information value within the segmented lesion region, and outputting a prognosis prediction value of the patient on the basis of the calculated at least one biomarker.