Abstract: The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention provides substituted imidazo[1,2-b]pyridazine compounds, substituted imidazo[1,5-b]pyridazine compounds, related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,2-b]pyridazine compounds described herein include substituted imidazo[1,2-b]pyridazine-3-carboxamide compounds and variants thereof.

Abstract: The present disclosure relates to computing blood pressure from images of the outer eye of an individual. Images of the outer eye of an individual obtained via a high magnification camera can be analyzed using computer vision to identify features associated with blood vessels in the outer eye, such as blood vessel size or diameter, blood vessel wall thickness, distance between vessels or vessel segments, area between vessels or vessel segments, and/or blood velocity through the vessels. These blood vessel features derived from images may be used to compute a blood pressure measure(s) for an individual through use of an artificial intelligence algorithm which relates the blood vessel features to blood pressure values.

Abstract: A system and a method for processing an image so as to perform instance segmentation. The system/method includes: a—inputting (S1) the image (IMG) to a first neural network configured to output an affinity graph (AF), and b—inputting (S2), to a second neural network, the affinity graph and a predefined seed-map (SM), so as to determine whether other pixels belong to a same instance, and set at a first value the value of the other pixels determined as belonging to the same instance.

Abstract: Generate an automorphism of the problem graph, determine an embedding of the automorphism to the hardware graph and modify the embedding of the problem graph into the hardware graph to correspond to the embedding of the automorphism to the hardware graph. Determine an upper-bound on the required chain strength. Calibrate and record properties of the component of a quantum processor with a digital processor, query the digital processor for a range of properties. Generate a bit mask and change the sign of the bias of individual qubits according to the bit mask before submitting a problem to a quantum processor, apply the same bit mask to the bit result. Generate a second set of parameters of a quantum processor from a first set of parameters via a genetic algorithm.

Abstract: A device for manufacturing a book on demand, including a cover printing or receiving station designed to respectively print or receive a cover, a body printing or receiving station designed to respectively print or receive a body, a binding station designed to join together the body and the cover, a conveyor designed and/or programmed to convey the cover and/or the body between the different stations, the device is designed to deposit glue in a gluing region on the verso of the cover inside the binding station before the cover and the body are joined together by gluing, forming a book.

Abstract: The invention provides a natural killer cell, NK-92, modified to express an Fc receptor on the surface of the cell, such as CD16 (Fc?RIII-A), or other Fc? or Fr receptors. The modified NK-92 cell can be further modified to concurrently express an associated accessory signaling protein, such as Fc?RI-?, TCR-?, or to concurrently express interleukin-2 (IL-2) or other cytokines. Additional methods are disclosed for various assays, assessments, and therapeutic treatments with the modified NK-92 cells.

Abstract: An ancillary laundry composition comprising 0.25 to 10 wt. % ester oil, free perfume and 0 to 4 wt. % anionic and/or cationic surfactant. A method of laundering clothes, wherein said composition is added in the wash or rinse stage. A method of preventing colour fade over (10) laundry cycles, wherein fabrics are treated with said composition during each consecutive laundry cycle. Use of said composition to provide an improved colour maintenance or reduced colour fade over consecutive laundry cycles, preferably (10), more preferably (5) laundry cycles.

Abstract: Disclosed is a composition for preventing and treating anti-inflammatory and autoimmune diseases and non-alcoholic fatty liver disease, wherein the composition for preventing and treating anti-inflammatory and autoimmune diseases and non-alcoholic fatty liver disease according to an embodiment of the present invention includes an extract of Centipeda minima extract including, as an active ingredient, at least one selected from the group consisting of Brebilin A, Arnicolide D, Arnicolide C, and Microhelenin C.

Abstract: An aqueous laundry liquid detergent comprising alkyl ether sulphate surfactant and alkyl ethoxylate surfactant, wherein either at least 10% wt. of the alkyl ether sulphate surfactant is C16 or C18 alkyl, or at least 10% wt. of the alkyl ethoxylate surfactant is C16 or C18 alkyl, from 0.01 to 3% wt. of the composition benzoate salt and wherein the composition has a pH of from 5.0 to 7.0.

Abstract: A cleansing composition includes 25% to 35% by weight of a surfactant, 1.5% to 5% by weight of a co-surfactant, 5% to 9% by weight of water; and 50% to 60% by weight of a fatty acid and soap mixture, wherein the fatty acid to soap ratio is 2.3:1 to 1.8:1. A method of making cleansing bars includes heating the cleansing composition to a temperature sufficient to provide a molten composition, cooling the molten composition to form flakes and/or chips, refining the flakes and/or chips to form billets, and stamping and/or cutting the billets to form the cleansing bars. Another method of making cleansing bars includes heating the cleansing composition to a temperature sufficient to provide a molten composition, pouring the molten composition into a mold, cooling the molten composition until the cleansing bars are formed, and removing the cleansing bars from the mold.

Abstract: The invention relates to the use of a ternary alloy having the formula SixTiyNiz, wherein x, y and z are natural numbers, for use in electrolysis and photoelectrolysis, in particular photo-oxidation of water. One aspect of the invention relates to a method for the manufacture of an electrode, the method comprising a step of heating a carrier comprising a surface having a layer of silicon on which a layer of TiO2 is disposed, the layer of TiO2 being covered with a layer of NiO; the heating step being carried out at a temperature above 1,000° C., and preferably between 1,150° C. and 1,250° C. The invention also relates to an electrode comprising a carrier, said electrode having either: an outer surface on which particles of a ternary alloy having the formula SixTiyNiz are positioned, wherein x, y and z are natural numbers, and wherein the particles form protrusions; or an outer surface consisting of a layer of said alloy, the layer comprising protrusions.

Abstract: The present invention relates to a novel process for the preparation of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4, 5, 6, 7-tetrahydropyrazolo[1,5-a] pyrimidine-3-carboxamide of formula-1 or its salts. The present invention also relates to novel process for the preparation of intermediate compound of Formula-7 and recovery of the intermediate compound of Formula-12, which is used in the preparation of compound of Formula-7. The compounds of formula-1 & formula-7 are represented by following structural formulae.

Abstract: Devices, systems and methods for a cloud-based meter management system are provided. The present disclosure includes a meter cloud server, a plurality of IEDs or meters, and one or more clients 608 (e.g., a web browser client), which are coupled together via a network (e.g., via various wireless and/or hardwired communication networks). The various components and modules of the present disclosure provide a plurality of functions to enable one or more users to manage a plurality of IEDs or meters via the at least one client device.

Abstract: The invention is a portable, climate controlled housing for sampling instrumentation having an outer housing and an insulted interior housing for receiving the sampling instrumentation, a sampling hose is connectable from the instrumentation to outside of the housing, a thermoelectric cooler device is provided within the outer housing to cool the interior of the outer housing, one or more exhaust fan are provided to remove air from inside the outer housing, a temperature probe is disposed within the interior insulated housing and a thermostat is operably connected to the exhaust fan, the cooler device and the temperature probe so that when the interior temperature of the insulated housing is detected to be outside a preferred range, the thermoelectric cooler device and the exhaust fan are operated until the interior temperature within the insulated housing is within a preferred range.

Abstract: An antiballistic armor-plating component, includes a ceramic body made of a material including, as percentages by volume, between 20% and 75% of boron carbide, between 5% an d 30% of a metallic silicon phase or of a metallic phase including silicon and between 20% and 70% of silicon carbide and wherein, as percentages by volume: more than 60% of the grains with an equivalent diameter greater than 60 micrometers are boron carbide grains, the boron carbide grains with an equivalent diameter greater than 30 micrometers represent more than 20%, the silicon carbide grains with an equivalent diameter greater than or equal to 10 micrometers represent more than 10%, the silicon carbide grains with an equivalent diameter less than 10 micrometers represent more than 10%.

Abstract: A second media rendering device in a network is synchronized with a first media rendering device in the network. At a first time s1, the second media rendering device sends a request for a current audio sample index from the first media rendering device. The first media rendering device receives the request for the current audio sample index from the second media rendering device. The first media rendering device sends a message including a first current audio sample index equal to a value for a first media rendering device internal sample index. At a second time s2 the second media rendering device receives the first current sample index value from the first media rendering device. The second media rendering device determines a transmission latency, and estimates an updated first media rendering device internal sample index value.

Abstract: Memory devices such as phase change memory (PCM) devices utilizing Ovonic Threshold Switching (OTS) selectors may be used to fill the gap between dynamic random-access memory (DRAM) and mass storage and may be incorporated in high-end microcontrollers. Since the programming efficiency and reading phase efficiency of such devices is directly linked to the leakage current of the OTS selector as well as sneak-path management, a sense amplifier disclosed herein generates an auto-reference that takes into account the leakage currents of unselected cells and includes a regulation loop to compensate for voltage drop due to read current sensing. This auto-referenced sense amplifier, built utilizing the principle of charge-sharing, may be designed on a 28 nm fully depleted silicon-on-insulator (FDSOI) technology, provides robust performance for a wide range of sneak-path currents and consequently for a large range of memory array sizes, and is therefore suitable for use in embedded memory in high-end microcontroller.

Abstract: In one embodiment, a generation facility for producing electricity includes one or more electricity generating elements for producing electricity from a renewable energy source. The generation facility also includes a controller conductively coupled to: (1) a first conductive path leading from the one or more electricity generating elements; (2) a second conductive path leading to a public utility network; and (3) a third conductive path leading to an energy storage system for storing electrical energy. The energy storage system is also conductively coupled to a fourth conductive path leading to the public utility network. The controller includes one or more processors coupled to a non-transitory computer readable storage media embodying software that is operable when executed by the processors to determine whether to send electricity generated by the one or more electricity generating elements to the energy storage system.