Abstract: The present invention is directed to a topical formulation comprising 1) a dispersed phase comprising: 5 to 15% w/w (percentage weight/weight) nicotinamide; 10 to 60% w/w of a partition coefficient enhancer (Pc enhancer), having a structure of the general formula: CnH2n+2O2 where n represents an integer from 3 to 6 inclusive; and ?10% water and 2) a continuous phase, wherein the formulation has a pH above 4.0. The present invention is also directed to a pharmaceutical composition comprising the topical formulation according to the invention, a pharmaceutical composition according to the invention for use in therapy, and the use of the topical formulation as a cosmetic agent.

Abstract: There is described a method for synchronizing a viewer-effect signal of a media content with a media signal of the media content. The method generally has: capturing an audio portion of the media signal from a surrounding environment using a microphone; obtaining a fingerprint from the captured audio portion of the media signal; from reference fingerprints associated with reference time positions of at least a reference media content, identifying a time position of the media content corresponding to the obtained fingerprint; obtaining the viewer-effect signal associated with the identified time position of the media content; and outputting the viewer-effect signal synchronized with the media signal using the identified time position of the media content for producing an effect to a viewer in synchronization with the media signal of the media content.

Abstract: The present invention relates to a novel use of trehalose. More particularly the present invention relates to a novel use of trehalose for promoting scalp health. Accordingly, the present invention provides use of trehalose as prebiotic for inhibiting ailment inducing microorganisms when applied on an external surface of a human body.

Abstract: A closure including an upper wall (25) defining an opening (36) and a cylindrical snap on pipe (30) depending from the upper wall. The pipe includes threads (34) designed to mate with external threads on a neck of the bottle. The threads on the pipe and threads on the neck of the bottle pass over each other when the closure is snapped onto the bottle during manufacture. The pipe includes a resistance recess (42) and a guidance recess (70). The resistance recess and the guidance recess accommodate a forcing element (50) on a shoulder (80) of the bottle and permit unscrewing of the closure. The walls (44, 46) of the resistance recess are preferably symmetrical.

Abstract: The present invention relates to a pantographic-type wiper system for cleaning a vehicle window that includes a drive attachment, a first arm, a second arm and a head configured to hold a wiper blade, where the first arm extends between the drive attachment and the head, where the second arm extends between a holding device attached to the drive attachment and the head, also characterized in that the wiper system includes a connecting body that links the first arm to the drive attachment and where the wiper system includes a pivot link (P) between the connecting body and the drive attachment and includes a rotational link (D) between the connecting body and the first arm; the wiper system also including at least a rotational device that allows motion around a first axis (A) that corresponds to a main elongation axis of the second arm between the head and the second arm or between the holding device and the second arm.

Abstract: A device and the associated method for detecting spoofing of GNSS signals are provided. The device includes an RF chain to acquire and down convert a signal comprising one or more GNSS signals transmitted by GNSS sources, each of the GNSS signals comprising a navigation message modulated by a spreading code associated to a related GNSS source, an analog to digital converter, to digitize the down converted signal, and a computer logic, to: calculate over a grid of spreading code phase delays and Doppler shifts, cross-correlation functions between the digitized signal and locally generated replicas of the signal, for one or more of the spreading codes, identify cross-correlation peaks, and analyze the cross-correlation peaks to detect spoofing situations.

Abstract: A solar power system for a metal shingled roof, including: a plurality of metal roofing shingles; and a plurality of solar module mounting assemblies, wherein each of the solar module mounting assemblies has upper and lower module cleats that support upper and lower solar module frames thereon such that the upper and lower module frames are both spaced apart in a direction parallel to the roof, and spaced apart in a direction perpendicular to the roof.

Abstract: Disclosed is a device for interaction between a laser beam and a hyperfine energy transition of a chemical species. The device further includes an electro-optic modulator with a single sideband with an input optical waveguide suitable for receiving a source laser beam and an output optical waveguide suitable for generating an output laser beam and an electronic system suitable for generating and applying, simultaneously, a first modulated electrical signal, sin(?1t)) to a first hyperfrequency pulse on a first high-frequency electrode of the electro-optic modulator and, respectively, another modulated electrical signal, cos(?1t)) to the first pulse on another high-frequency electrode of the electro-optic modulator, in such a way as to frequency-switch the output laser beam to a first optical frequency offset from the first pulse with respect to the initial optical frequency.

Abstract: The invention relates to an adapter for a wiper blade mounting, the adapter comprising a cover which can be releasably attached to a main bar of the mounting by a single rotational movement that allows form-closure engagement between the cover and the main bar. According to the invention, the cover comprises an angular indexing system for defining an axis of rotation of the cover, the angular indexing system cooperating with an opening in the main bar. The opening and the angular indexing system have an asymmetrical form in order to allow angular indexing of the cover relative to the main bar and, subsequently, mechanical coupling of the cover on the main bar. The invention is applicable to motor vehicles.

Abstract: The present disclosure provides processes for preparing a crystalline form of 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile and related intermediate compounds.

Abstract: HM30181 (shown below) can be used to improve absorption of cancer chemotherapy drugs, such as paclitaxel. Herein are described various polymorphisms of HM30181, in particular polymorphism C, as well as their physical properties and methods for their preparation and characterization.

Abstract: A seat backrest having a frame and a cover extending around at least part of the frame, the cover defining at least part of the outer surface of the backrest. The seat backrest includes an airbag module, having a housing receiving an airbag, that is attached to the frame in an attachment area. At least in the attachment area, the cover is in direct contact with the frame and extends between the frame and the housing of the airbag module. The housing is attached to the frame through the cover and extends entirely to the side of the outer surface of the backrest.

Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.

Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.

Abstract: Disclosed is an integrated pump assembly for a liquid dispensing device and a liquid dispensing device thereof. The pump assembly for the liquid dispensing device comprises a flow path board formed with a flow path therein to receive liquid from a liquid source and dispense a gas-liquid mixture, a gas-liquid mixing pump connected with the flow path board to receive the liquid therefrom and return the gas-liquid mixture thereto, and a main control board for controlling the operation of the gas-liquid mixing pump, wherein the flow path board comprises an upper board and a lower board fitted to each other with the flow path formed therebetween. The liquid dispensing device comprises a housing, said pump assembly configured to be accommodated in said housing and a power supply to supply power to said pump assembly.

Abstract: The invention relates to the treatment of genetic dilated cardiomyopathies using expressible modulators of the Wnt pathway or TGF-? pathway, preferably using gene transfer.

Abstract: The present invention is directed to a naturally derived surfactant system and an end use composition comprising the surfactant system. The naturally derived surfactant system comprises an anionic and nonionic surfactant comprising polyglycerol ester that is stable in an end use composition having a pH from 4.8 to 6.5. Such end use compositions are mild, have excellent lathering characteristics, and do not require glycinates, polyglycosides, betaines, sultaines and sulfates.

Abstract: A wiper blade (12) is disclosed having a support connector (18) for at least one wiper rubber (14), an adapter (20) that is able to take a front-end terminal part (10) of a drive arm of the wiper blade (12) which is mounted so as to be articulated with respect to the connector (18), about an articulation axis (A), between a working position and a maintenance position, and which has a locking member (32) for locking said terminal part (10) to the adapter (20), which is mounted so as to be movable between a locking position and a retracted position releasing said terminal part (10). The wiper blade (12) has a member (68, 38) for immobilizing the locking member (32) in the locking position when the adapter (20) is in the working position, and for releasing the locking member (32) when the adapter (20) is in the maintenance position.

Abstract: Apparatus and associated methods relate to an energy efficient and pollution reducing post top lamp. In an illustrative example, a replaceable light unit (RLU) includes a LED package distributed about a first axis of the RLU. The LED package, for example, may emit a light being redirected by a first optical element to generate a first optical distribution along a first optical axis in a first direction, the first optical axis being substantially parallel to the first axis. The first optical distribution may be, for example, reflected by a second optical element such that at least a portion of the light in the first optical distribution may be reflected into a second optical distribution. For example, at least fifty percent of the light in the second optical distribution may be greater than fifty degrees from the first optical axis. Various embodiments may advantageously conserve energy and/or reduce light pollution.