Patents Assigned to Dabur Research Foundation
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Publication number: 20080207935Abstract: We disclose here processes for making Platinum complex of general formula (I) where in, the conformation of 1,2-diaminocyclohexane is cis, trans-l or trans-d isomer and R1 and R2 combinedly make dicarboxylic acid having formulae (II), (III) and (IV), here in, the two carboxylic acid groups are on the same or on vicinal carbon atoms, n is zero or an integer ranging from 1 to 5 and R3 is either hydrogen or a substituent with electron withdrawing or electron releasing effects exemplified by alkoxy, halo, and nitro groups by reacting a compound of formula M2PtX4 wherein X represents halogen atom such as Cl or Br or thiocyanate with (i) 1,2-diaminocyclohexane (ii) source of silver ion selected from a silver compound containing divalent anion in presence of a corresponding carboxylic acid of formula (II) or (III) or (IV) to get the compound of formula (I), purifying the said compound by treating with alkali metal iodide and isolating the title compound by any conventional methods.Type: ApplicationFiled: February 5, 2004Publication date: August 28, 2008Applicant: DABUR RESEARCH FOUNDATIONInventors: Golak Chandra Maikap, Bhagat Raj, Pradipta Kumar, Kannan Vivekanandan, Chandrakant Belwal
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Publication number: 20070093422Abstract: The present invention relates to a combination of peptides that may be used for treatment of cancer. The peptide combination competes for the binding of specific neuropeptides at the plasma membrane and thereby alters the levels of key intracellular molecules implicated in cell proliferation, resulting in a broad spectrum of anticancer activity. The invention also relates to pharmaceutical compositions containing a combination of such peptide analogs.Type: ApplicationFiled: December 21, 2006Publication date: April 26, 2007Applicant: DABUR RESEARCH FOUNDATIONInventors: Rama Mukherjee, Anand Burman, Anu Singh, Manu Jaggi, Sudhanand Prasad, Sarjana Dutt
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Patent number: 7179937Abstract: The invention relates to the use of derivatives of cyclopentenone for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of derivatives of cyclopentenone for the inhibition and/or prevention of cancer of the colon, pancreas, larynx, ovary, duodenum, kidney, oral cavity, prostate, lung, endothelial cells and leukemias.Type: GrantFiled: December 4, 2002Date of Patent: February 20, 2007Assignee: Dabur Research FoundationInventors: Mukund K. Gurjar, Radhika D. Wakharkar, Gautam R. Desiraju, Ashwini Nangia, Jhillu Singh Yadav, Anand C. Burman, Rama Mukherjee, Hanumant Bapu Rao Borate, Srivari Chandrasekhar, Manu Jaggi, Anuo T. Singh, Kamal Kapoor, Sanjay Sarkhel, K. V. V. M. Sairam
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Patent number: 7173006Abstract: The present invention relates to a combination of peptides that may be used for treatment of cancer. The peptide combination competes for the binding of specific neuropeptides at the plasma membrane and thereby alters the levels of key intracellular molecules implicated in cell proliferation, resulting in a broad spectrum of anticancer activity. The invention also relates to pharmaceutical compositions containing a combination of such peptide analogs.Type: GrantFiled: December 23, 2002Date of Patent: February 6, 2007Assignee: Dabur Research FoundationInventors: Rama Mukherjee, Anand C. Burman, Anu T. Singh, Manu Jaggi, Sudhanand Prasad, Sarjana Dutt
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Patent number: 7094755Abstract: The present invention encompasses novel analogs of vasoactive intestinal peptide (VIP), containing substitutions at appropriately selected amino acids. The invention particularly relates to the design and synthesis of novel biologically active VIP analogs containing ?, ?-dialkylated amino acids in a site-specific manner. Specifically, the invention relates to the synthesis of VIP peptide derivatives, which bind selectively to VIP receptors on target cells. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.Type: GrantFiled: September 25, 2002Date of Patent: August 22, 2006Assignee: Dabur Research FoundationInventors: Anand C. Burman, Sudhanand Prasad, Rama Mukherjee, Anu T. Singh, Archna Mathur, Neena Gupta
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Patent number: 7060678Abstract: Anticancer peptides which incorporate furanoid sugar amino acids and compositions made using these peptides are described. Methods for synthesis of the peptides and for preparing the furanoid sugar amino acids are disclosed. The peptides and compositions made using the peptides have pharmacological applications of these peptides especially in the treatment and prevention of cancer and tumors.Type: GrantFiled: August 8, 2003Date of Patent: June 13, 2006Assignee: Dabur Research FoundationInventors: Sudhanand Prasad, Tushar Kanti Chakraborty, Archna Mathur, Manu Jaggi, Ajit Chand Kunwar, Rama Mukherjee, Anand C. Burman
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Patent number: 6989371Abstract: The present invention encompasses novel peptides that are antagonists to bombesin and bombesin like peptides and are useful in the treatment of cancer. The invention particularly relates to the design and synthesis of the novel peptides incorporating ?,?-amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.Type: GrantFiled: July 31, 2000Date of Patent: January 24, 2006Assignee: Dabur Research FoundationInventors: Anand C. Burman, Sudhanand Prasad, Rama Mukherjee, Manu Jaggi, Anu T. Singh, Archna Mathur
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Patent number: 6949513Abstract: A polypeptide of the formula (I), Pa-L-Pb-L-Pc-L-Pd.Type: GrantFiled: June 28, 2002Date of Patent: September 27, 2005Assignee: Dabur Research FoundationInventors: Sudhanand Prasad, Rama Mukherjee, Anand C. Burman, Archna Mathur, Rajan Sharma, Manu Jaggi
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Patent number: 6949557Abstract: The invention relates to the use of novel anthracene based compounds for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of hydroanthracene based compounds for the inhibition and/or prevention of cancer of the colon, pancreas, prostate, lung, larynx, ovary, breast, glioblastoma, oral cavity, endothelial cells and leukemias. The agents of the invention form a distinct class, distinct from the anthracene, anthrone or anthraquinone derivatives.Type: GrantFiled: April 29, 2003Date of Patent: September 27, 2005Assignee: Dabur Research FoundationInventors: Asish Kumar Banerjee, Venkatachalam Sesha Giri, Rama Mukherjee, Kamal K. Kapoor, Gautam Desiraju, Manu Jaggi, Anu T. Singh, Sankar Kumar Dutta, Kalapatapu V. V. M. Sairam
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Patent number: 6828304Abstract: This invention relates to novel antiproliferative and anti secrectory peptides that are inhibitory to vasoactive intestinal peptide receptor and are useful in the treatment of cancer. The invention particularly relates to the synthesis of lipid-peptide conjugates containing fatty acids of different sizes, which inhibits the binding of VIP to its receptors. The invention encompasses methods for generation of these peptides, composition containing these peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.Type: GrantFiled: July 31, 2000Date of Patent: December 7, 2004Assignee: Dabur Research FoundationInventors: Anand C. Burman, Sudhanand Prasad, Rama Mukherjee, Manu Jaggi, Anu T. Singh, Rajan Sharma
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Publication number: 20040220197Abstract: The invention relates to the use of novel anthracene based compounds for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of hydroanthracene based compounds for the inhibition and/or prevention of cancer of the colon, pancreas, prostate, lung, larynx, ovary, breast, glioblastoma, oral cavity, endothelial cells and leukemias. The agents of the invention form a distinct class, distinct from the anthracene, anthrone or anthraquinone derivatives.Type: ApplicationFiled: April 29, 2003Publication date: November 4, 2004Applicant: DABUR RESEARCH FOUNDATIONInventors: Asish Kumar Banerjee, Venkatachalam Sesha Giri, Rama Mukherjee, Kamal K. Kapoor, Gautam Desiraju, Manu Jaggi, Anu T. Singh, Sankar Kumar Dutta, Kalapatapu V.V.M. Sairam
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Publication number: 20040171560Abstract: A stabilized pharmaceutical composition of anticancer drug and a solvent like dehydrated alcohol is disclosed. A method is disclosed that includes the addition of a stabilizing agent Malic acid having a unique triple action property of being an antioxidant, a chelating agent and an acidifying agent. Compositions prepared using this pre-treated dehydrated alcohol enhance the stability of paclitaxel in alcohol. A method of removing ionic, metallic and oxidizing impurities from alcohol using ion exchange and clay treatment is also disclosed.Type: ApplicationFiled: December 19, 2003Publication date: September 2, 2004Applicant: DABUR RESEARCH FOUNDATIONInventors: Rama Mukherjee, Arnand C. Burman, Dhiraj Khattar, Mukesh Kumar
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Publication number: 20040121950Abstract: The present invention relates to a combination of peptides that may be used for treatment of cancer. The peptide combination competes for the binding of specific neuropeptides at the plasma membrane and thereby alters the levels of key intracellular molecules implicated in cell proliferation, resulting in a broad spectrum of anticancer activity. The invention also relates to pharmaceutical compositions containing a combination of such peptide analogs.Type: ApplicationFiled: December 23, 2002Publication date: June 24, 2004Applicant: DABUR RESEARCH FOUNDATIONInventors: Rama Mukherjee, Anand C. Burman, Anu T. Singh, Manu Jaggi, Sudhanand Prasad, Sarjana Dutt
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Publication number: 20040116394Abstract: This invention relates to an orally effective herbal extract-based composition having broad-spectrum anticancer activity, more specifically a method of treating, inhibiting and/or preventing malignant tumors of the colon, intestine, stomach, breast, melanoma, glioblastoma, lung, cervix, ovary, prostate, oral cavity, larynx, liver, pancreas, kidney, bladder, endothelial cells, leukemia and myeloma using a herbal extract of Zizyphus, rich in betulinic acid. An advantage of the extract is that the betulinic acid has low systemic toxicity. The extract inhibits Protein Kinase C activity of cancer cells and induces apoptosis.Type: ApplicationFiled: December 13, 2002Publication date: June 17, 2004Applicant: DABUR RESEARCH FOUNDATIONInventors: Rama Mukherjee, Dhiraj Khattar, Manu Jaggi, Anu T. Singh, Mukesh Kumar, Honey Bala
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Patent number: 6670345Abstract: The invention relates to the use of betulinic acid derivatives for the inhibition and or prevention of cancer growth. The invention also relates to novel betulinic acid derivatives useful for inhibition of tumor cancer cells and a process for the preparation of the derivatives. The invention also relates to anti-leukemic and anti-lymphoma activity of the betulinic acid derivatives, and the use of the derivatives for the treatment of prostate, lung, laryngeal, colon and ovarian cancer.Type: GrantFiled: November 2, 1999Date of Patent: December 30, 2003Assignee: Dabur Research FoundationInventors: Sunder Ramadoss, Manu Jaggi, Mohammad Jamshed Ahmad Siddiqui, Achla Behl Khanna
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Publication number: 20030229146Abstract: The invention relates to the use of derivatives of cyclopentenone for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds.Type: ApplicationFiled: December 4, 2002Publication date: December 11, 2003Applicant: DABUR RESEARCH FOUNDATIONInventors: Mukund K. Gurjar, Radhika D. Wakharkar, Gautam R. Desiraju, Ashwini Nangia, J. S. Yadav, Anand C. Burman, Rama Mukherjee, Hanumant Bapurao Borate, Srivari Chandrasekhar, Manu Jaggi, Anuo T. Singh, Kamal K. Kapoor, Sanjay Sarkhel, Kalapatapu V.V.M. Sairam
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Patent number: 6656970Abstract: The present invention provides compositions and methods for the solubilization of poorly soluble drugs such as triterpenes like betulinic acid and/its derivatives in pharmaceutically acceptable liquid vehicles that avoid use of potentially toxic solvents that are often used for the solubilization of poorly soluble drugs. In the compositions of this invention the drugs remain physically and chemically stable and can be administered intravascularly without undue toxicity from undissolved drug and/or from the solvent vehicles at a drug dose meant to be effective to exhibit clinically significant anticancer activity.Type: GrantFiled: March 8, 2001Date of Patent: December 2, 2003Assignee: Dabur Research FoundationInventors: Anand C. Burman, Rama Mukherjee, Honey Bala, Dhiraj Khattar
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Patent number: 6632832Abstract: The present invention provides for pharmaceutical compositions comprising carvedilol for treatment of cancer. More particularly the invention relates to the use of carvedilol for treatment of cancers of the colon, ovary, breast, prostate, pancreas, lung, melanoma, glioblastoma, oral cancer and leukemias. Although not bound to any theory, the anticancer activity of carvedilol appears to be attributed to the inhibition of Epidermal Growth Factor and Platelet derived growth factor dependent proliferation of cancer cells. Further, carvedilol exerts anticancer effect by inhibition of the Protein kinase C (PKC) activity and that of the cyclooxygenase 2 enzyme. The invention also relates to the anticancer activity of the optically pure isomers S(−) and R(+) of carvedilol and the use of carvedilol and its isomers in pharmaceutical compositions for the treatment of cancer.Type: GrantFiled: September 10, 2002Date of Patent: October 14, 2003Assignee: Dabur Research FoundationInventors: Anand C. Burman, Rama Mukherjee, Manu Jaggi, Anu T. Singh
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Patent number: 6613793Abstract: The invention relates to the use of imino acid conjugates of methylglyoxal for the inhibition and/or treatment of cancer. The invention relates more specifically to the use imino acid conjugates of methylglyoxal for inhibition and/or treatment of cancer of the Colon, Prostate, Larynx, Kidney, Pancreas, Lung, Breast, Intestine, Oral cavity, Ovary, Glioblastoma, and Leukemia. The invention also relates to compositions and methods of inhibiting cancer using imino acid conjugates of methylglyoxal.Type: GrantFiled: July 1, 2002Date of Patent: September 2, 2003Assignee: Dabur Research FoundationInventors: Anand C. Burman, Rama Mukherjee, Manu Jaggi, Anu T. Singh, Kamal K. Kapoor, Sudhanand Prasad, Manju Ray
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Publication number: 20030158110Abstract: The present invention encompasses novel analogs of vasoactive intestinal peptide (VIP), containing substitutions at appropriately selected amino acids. The invention particularly relates to the design and synthesis of novel biologically active VIP analogs containing &agr;, &agr;-dialkylated amino acids in a site-specific manner. Specifically, the invention relates to the synthesis of VIP peptide derivatives, which bind selectively to VIP receptors on target cells. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.Type: ApplicationFiled: September 25, 2002Publication date: August 21, 2003Applicant: DABUR RESEARCH FOUNDATIONInventors: Anand C. Burman, Sudhanand Prasad, Rama Mukherjee, Anu T. Singh, Archna Mathur, Neena Gupta