Abstract: The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant having a reduced feedback inhibition by histidine and a strain expressing the same. The variant may maintain its activity even at a high histidine concentration, thus increasing histidine production.
Type:
Application
Filed:
April 26, 2021
Publication date:
February 29, 2024
Applicant:
DAESANG CORPORATION
Inventors:
Jong Yun HAN, Chel Min YANG, Yong Soo KIM, Young Il JO
Abstract: The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant having a reduced feedback inhibition by histidine and a strain expressing the same. The variant may maintain its activity even at a high histidine concentration, thus increasing histidine production.
Type:
Application
Filed:
April 26, 2021
Publication date:
February 22, 2024
Applicant:
DAESANG CORPORATION
Inventors:
Jong Yun HAN, Chel Min YANG, Yong Soo KIM, Young Il JO
Abstract: The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant having a reduced feedback inhibition by histidine and a strain expressing the same. The variant may maintain its activity even at a high histidine concentration, thus increasing histidine production.
Type:
Application
Filed:
April 26, 2021
Publication date:
February 22, 2024
Applicant:
DAESANG CORPORATION
Inventors:
Jong Yun HAN, Chel Min YANG, Yong Soo KIM, Young Il JO
Abstract: The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant having a reduced feedback inhibition by histidine and a strain expressing the same. The variant may maintain its activity even at a high histidine concentration, thus increasing histidine production.
Type:
Application
Filed:
April 26, 2021
Publication date:
February 22, 2024
Applicant:
DAESANG CORPORATION
Inventors:
Jong Yun HAN, Chel Min YANG, Yong Soo KIM, Young Il JO
Abstract: The present invention provides a novel allulose epimerase variant in which an amino acid residue present at a specific position of an amino acid sequence of wild-type D-allulose 3-epimerase derived from Flavonifractor plautii is substituted with another amino acid residue, and various uses thereof. The novel allulose epimerase variant according to the present invention has a higher conversion activity of fructose to allulose than that of the wild-type D-allulose 3-epimerase derived from Flavonifractor plautii or a D-allulose epimerase variant W29K/G216S/M234I, and has excellent thermal stability especially under high temperature conditions of 60° C. or higher, thereby preventing contamination during an industrial-scale enzymatic conversion reaction for the mass production of allulose, shortening the production time, and reducing the production costs.
Type:
Application
Filed:
November 22, 2021
Publication date:
February 15, 2024
Applicant:
DAESANG CORPORATION
Inventors:
Ji Ha LEE, Tae Gyun KIM, Baek Joong KIM, Da Han JUNG, Seung Woo CHO, Hak Jun KIM
Abstract: Disclosed is a mutant strain having improved aromatic amino acid production capability as a result of the inactivation or weakening of activity of asparaginase which is expressed by ansB gene.
Type:
Application
Filed:
October 19, 2023
Publication date:
February 8, 2024
Applicant:
DAESANG CORPORATION
Inventors:
Won Joo SHIN, Young II Jo, Sun Hee Lee, Hyun Young Kim, Yong Soo Kim, Cheol Min Yang
Abstract: The present disclosure relates to a Corynebacterium sp. mutant strain having increased L-arginine or L-citrulline productivity and a method of producing L-arginine or L-citrulline using the same. The Corynebacterium sp. mutant strain has enhanced activity of acetylglutamate kinase involved in the L-arginine biosynthesis pathway, and thus is capable of producing L-arginine or L-citrulline in an increased yield compared to a parent strain.
Type:
Application
Filed:
October 4, 2022
Publication date:
January 25, 2024
Applicant:
DAESANG CORPORATION
Inventors:
Mi RYU, Sun Jun Yoon, In Pyo Hong, Seok Hyun Park
Abstract: The present disclosure relates to a Corynebacterium sp. mutant strain having increased L-arginine or L-citrulline productivity and a method of producing L-arginine or L-citrulline using the same. The Corynebacterium sp. mutant strain has enhanced activity of acetylornithine aminotransferase involved in the L-arginine biosynthesis pathway, and thus is capable of producing L-arginine or L-citrulline productivity in an increased yield compared to a parent strain.
Type:
Application
Filed:
October 4, 2022
Publication date:
January 25, 2024
Applicant:
DAESANG CORPORATION
Inventors:
Mi RYU, Sun Jun YOON, In Pyo HONG, Seok Hyun PARK
Abstract: The present invention relates to a Corynebacterium glutamicum mutant strain having increased L-citrulline productivity and a method of producing L-citrulline using the same. The Corynebacterium glutamicum mutant strain is capable of producing L-citrulline in high yield and high concentration because the activity of the transport protein that is expressed by the NCgl2816 gene therein has been weakened or inactivated.
Type:
Application
Filed:
March 23, 2021
Publication date:
October 19, 2023
Applicant:
DAESANG CORPORATION
Inventors:
Dong Seok LEE, Min Jin CHOI, Moon Jeong KIM, Seok Hyun PARK, Jae Chun HAN
Abstract: The present disclosure relates to a Corynebacterium glutamicum mutant strain having enhanced L-lysine productivity and a method of producing L-lysine using the same. The Corynebacterium glutamicum mutant strain may produce L-lysine in an improved yield by inhibiting the conversion of oxaloacetate to citrate due to decreased or inhibited expression of the gene encoding the citrate synthase.
Type:
Application
Filed:
April 20, 2021
Publication date:
October 5, 2023
Applicant:
DAESANG CORPORATION
Inventors:
Mi RYU, In Pyo HONG, Min Jin CHOI, Seok Hyun PARK, Jae Chun HAN
Abstract: Provided are a beverage composition comprising: chlorophyll-deficient Chlorella; a specific gum as a stabilizer; and an aqueous liquid medium and a process for preparing the same, wherein the beverage composition exhibits excellent dispersion stability without precipitation, and prevent the browning phenomenon occurring in a sterilization process.
Type:
Application
Filed:
August 25, 2021
Publication date:
October 5, 2023
Applicant:
DAESANG CORPORATION
Inventors:
Bo-Ra KIM, Ji-Eun HWANG, Jin-Young JEON
Abstract: A composition for preparing a protein-containing noodle containing a vegetable raw material and a method for preparing a protein-containing noodle using the same are disclosed. The composition for preparing a protein-containing noodle contains vegetable proteins, potato fibers, alginate, and starch. According to embodiments, low-calorie, high-protein-containing noodles with high protein content and excellent flavor may be prepared by using vegetable protein as the main raw material for noodles, and the mouthfeel and textural properties of the noodles may be greatly improved by using the vegetable proteins in combination with potato fibers, alginate, and starch. In addition, the raw material pretreatment and noodle making process are simplified, and thus, noodles may be prepared in a simple way and may be applied to mass production.
Type:
Application
Filed:
October 13, 2021
Publication date:
August 10, 2023
Applicant:
DAESANG CORPORATION
Inventors:
Yong Gun KIM, Myung Hee BYUN, Joong Hyun JIN, Doo Hyun AN, Yu Hwan KIM
Abstract: The present invention relates to a strain which has increased glutamine productivity due to being transformed with a vector containing a nucleotide sequence that encodes a glutamine synthetase consisting of the amino acid sequence of SEQ ID NO: 1.
Type:
Application
Filed:
March 24, 2021
Publication date:
July 13, 2023
Applicant:
DAESANG CORPORATION
Inventors:
In Pyo HONG, Bong Ki KIM, Min Jin CHOI, Seok Hyun PARK, Jae Chun HAN
Abstract: The present invention relates to a method of producing a flavor by a co-fermentation process using mixed fermentation of two or more different microorganisms producing different products. The method of producing a flavor may produce a natural flavor capable of improving the taste and aroma of food and the overall sensory properties of food through a fermentation broth containing amino acids, nucleic acids and/or organic acids, which is produced by mixed fermentation of different microorganisms producing different products, that is, different kinds of amino acids, nucleic acids and/or organic acids. This flavor may be used in various food fields.
Type:
Application
Filed:
July 14, 2022
Publication date:
July 13, 2023
Applicant:
DAESANG CORPORATION
Inventors:
Hyun Ho KIM, Sun Hee LEE, Dong Hyun KIM, Hyun Sook KIM, Seok Hyun PARK, Joon Hyun PARK
Abstract: The present invention relates to a Corynebacterium glutamicum mutant strain having increased L-glutamic acid productivity, a method for constructing the same, and a method of producing L-glutamic acid using the same. The Corynebacterium glutamicum mutant strain is a strain into which a mechanosensitive ion channel gene derived from a Corynebacterium sp. strain has been introduced, and thus it can produce L-glutamic acid in an improved yield due to enhancement of glutamic acid release. Therefore, when the mutant strain is used, it is possible to more effectively produce L-glutamic acid.
Type:
Application
Filed:
August 26, 2020
Publication date:
May 4, 2023
Applicant:
DAESANG CORPORATION
Inventors:
Young Ju LEE, Bong Ki KIM, Min Jin CHOI, Seok Hyun PARK, Jae Chun HAN
Abstract: The present invention provides: a novel allulose epimerase variant in which an amino acid residue present at a specific position of an amino acid sequence of a wild-type D-allulose 3-epimerase derived from Flavonifractor plautii is substituted with another amino acid residue; and various uses of the novel allulose epimerase variant. The novel allulose epimerase variant according to the present invention has a higher conversion rate of fructose to allulose compared to that of the wild-type D-allulose 3-epimerase derived from Flavonifractor plautii, and has excellent thermal stability especially under high temperature conditions of 60° C. or higher, and thus can prevent contamination during an industrial-scale enzymatic conversion reaction for the mass production of allulose, shorten production time, and reduce production costs.
Type:
Grant
Filed:
April 27, 2021
Date of Patent:
April 25, 2023
Assignee:
DAESANG CORPORATION
Inventors:
Hyung Seop Youn, Eun Seok Choi, Ji Ha Lee, Suok Su Kim, Seung Woo Cho, Tae Yong Kim, Hak Jun Kim
Abstract: The present invention provides: a novel allulose epimerase variant in which an amino acid residue present at a specific position of an amino acid sequence of a wild-type D-allulose 3-epimerase derived from Flavonifractor plautii is substituted with another amino acid residue; and various uses of the novel allulose epimerase variant. The novel allulose epimerase variant according to the present invention has a higher conversion rate of fructose to allulose compared to that of the wild-type D-allulose 3-epimerase derived from Flavonifractor plautii, and has excellent thermal stability especially under high temperature conditions of 60° C. or higher, and thus can prevent contamination during an industrial-scale enzymatic conversion reaction for the mass production of allulose, shorten production time, and reduce production costs.
Type:
Application
Filed:
April 27, 2021
Publication date:
February 23, 2023
Applicant:
DAESANG CORPORATION
Inventors:
Hyung Seop YOUN, Eun Seok CHOI, Ji Ha LEE, Suok Su KIM, Seung Woo CHO, Tae Yong KIM, Hak Jun KIM
Abstract: Provided is a mutant strain having improved aromatic amino acid production capability as a result of inactivation or weakening of activity of glutaminase which is expressed by glutaminase B (glsB) gene.
Type:
Application
Filed:
June 26, 2020
Publication date:
February 16, 2023
Applicant:
DAESANG CORPORATION
Inventors:
Won Joo SHIN, Young Il JO, Sun Hee LEE, Hyun Young KIM, Yong Soo KIM, Cheol Min YANG
Abstract: Disclosed is a mutant strain having improved aromatic amino acid production capability due to inactivation or weakening of activity of an FMN/FAD exporter protein which is expressed by yeeO gene.
Type:
Application
Filed:
June 26, 2020
Publication date:
December 29, 2022
Applicant:
DAESANG CORPORATION
Inventors:
Won Joo SHIN, Young Il JO, Sun Hee LEE, Hyun Young KIM, Yong Soo KIM, Cheol Min YANG
Abstract: Disclosed is a mutant strain having improved aromatic amino acid production capability as a result of the inactivation or weakening of activity of asparaginase which is expressed by ansB gene.
Type:
Application
Filed:
June 26, 2020
Publication date:
November 24, 2022
Applicant:
DAESANG CORPORATION
Inventors:
Won Joo SHIN, Young Il JO, Sun Hee LEE, Hyun Young KIM, Yong Soo KIM, Cheol Min YANG