Abstract: 1,2-Diphenylethanolamine derivatives of the formula: ##SPC1##Wherein R.sub.1 and R.sub.2 are each hydrogen, a halogen, nitro, hydroxy, an alkyl or methoxy; R.sub.3 is a group of the formula: ##SPC2##Wherein R.sub.4, R.sub.5 and R.sub.6 are each hydrogen, a halogen or methoxy and n is an integer of 0 to 3, or a pyridyl; and Z is hydroxy or an acyloxy; with proviso that when R.sub.1 and/or R.sub.2 are hydroxy, Z is hydroxy, and their pharmaceutically acceptable salts, which have excellent analgesic and anti-tussive activities, and a process for the preparation thereof.

Abstract: A reagent for determining lipase activity, which comprises as the active ingredient one of the S-acyl compounds of the formula: ##EQU1## WHEREIN N IS AN INTEGER OF 2 TO 4, INCLUSIVE; N' IS AN INTEGER OF 2 TO 4, INCLUSIVE OR OF 9 TO 13, INCLUSIVE; M IS AN INTEGER OF 3, 7 OR 11; M' IS AN INTEGER OF 4 OR 12; Y IS AN INTEGER OF 1 OR 2; X is sulfur atom or oxygen atom; Y is sulfur atom, oxygen atom or ethylene group; provided that when y is 1, m' is 4 and when y is 2, m' is 12, and a method for determining lipase activity by reacting the S-acyl compound with lipase in a buffer solution containing a chromogenic sulfhydryl reagent and then subjecting the resultant to a colorimetry.

Abstract: An enzyme being capable of lysing cells of dental caries-inducing microorganisms and a method for producing the same by cultivating a microorganism belonging to the genus Streptomyces, especially wild type strains of Streptomyces diastatochromogenes, Streptomyces farinosus, Streptomyces globisporus and Streptomyces griseus var. H-402, compositions for preventing and treating dental caries containing the said enzyme and methods for preventing and treating dental caries.

Abstract: New .omega.-(N-acylamino)alkylphosphoryl ethanolamines and their pharmaceutically acceptable acid addition salts have superior renin-inhibitory activities, antihypertensive activities and cholesterol-lowering activities. The .omega.-(N-acylamino)alkylphosphoryl ethanolamines are prepared by (1) reacting an .omega.-(N-acylamino) alkanol with a 2-(N-substituted amino)ethyl phosphate or its derivative, hydrolyzing the resulting product or splitting off the phosphoric acid-protective group of the resulting product thereby to form an .omega.-(N-acylamino) alkyl 2-(N-substituted amino) ethyl phosphate, and splitting off the amino-protective groups of the resulting phosphate, or (2) reacting an .omega.-(N-acylamino) alkanol with a phosphorus oxyhalide, reacting the resulting .omega.-(N-acylamino)alkyl dichlorophosphate with a 2-(N-substituted amino) ethanol, hydrolyzing the reaction product to form an .omega.

Abstract: Hexahydro-.gamma.-carboline derivatives of the formula: ##SPC1##Wherein R.sub.1 is methyl or ethyl, and R.sub.2 is hydrogen, methyl or ethyl, with proviso that when R.sub.1 is ethyl, R.sub.2 is hydrogen, and their pharmaceutically acceptable acid addition salts, which exhibit excellent psychotropic effect, and a process for the preparation thereof.

Abstract: Pyrimidine compositions or their non-toxic acid-addition salts are used for preventing and treating infectious diseases of fish caused by pathogenic microorganisms.

Abstract: This invention provides compounds of the following formula ##SPC1##Wherein R.sub.1 is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a hydroxyalkyl group having 2 to 4 carbon atoms, a benzyl group, a benzyl group subsituted by methoxy, a phenyl group, a propargyl group or an acyl group; R.sub.2 is hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkyl group having 2 to 4 carbon atoms substituted by hydroxy or halogen, a vinyl group, an allyl group, or a benzyl group R.sub.3 is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms;And salts thereof, and processes for preparing them. Some of the compounds have antibacterial activities.

Abstract: 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##SPC1##Wherein X is hydroxy, methoxy, methyl or trifluoromethyl; and R is an unsubstituted monocycloalkyl group having 6 to 8 carbon atoms or 2-methoxyphenyl; provided that when X is hydroxy, R is cyclohexyl, and when X is trifluoromethyl, R is 2-methoxyphenyl,And their pharmaceutically acceptable salts, which have excellent analgesic, anti-tussive and anti-inflammatory activities, without undesirable side effect such as narcotic activity, and a process for the preparation thereof.

Abstract: 3-Substituted-1,2-benzisoxazole derivative of the following formula: ##SPC1##Wherein R.sub.1 is hydrogen, hydroxy, nitro, alkyl, alkoxy, halogen or amino; R.sub.2 is hydroxyamino, amino, hydrazino, mono- or di- alkyl substituted amino, aralkylamino, acyloxyamino, morpholino, piperazine which is unsubstituted or substituted with alkyl, aralkyl or aryl at 4 position, or pyrrolidino, or R.sub.2 may combine with imino group and form together with the adjacent carbon atom a heterocyclic ring such as imidazoline or tetrahydropyrimidine; and n is an integer of 0 to 3, and its pharmaceutically acceptable acid addition salt, and preparation thereof. The present compounds show valuable pharmacological properties, such as anti-reserpine activity, central nervous depressing activity, anti-hypertensive activity and l-dopa potentiating activity.

Abstract: .omega.-[Bis(.omega.,.omega.-diphenylalkyl)amino]alkan-1-ol having the following formula: ##SPC1##And their pharmaceutically acceptable acid addition salts which are useful for preventing and treating cerebral vascural diseases caused by cerebral blood flow disorder, processes for preparing the compounds and pharmaceutical compositions containing the compound.