Abstract: An angiogenesis inhibitor effective in inhibiting angiogenesis which causes a disease is obtained by, for example, sterilely filtrating, disinfecting, and concentrating a product which is obtained as follows. That is, rice bran is extracted with hot water, the insoluble matter is filtrated, and the starch is decomposed by processing the filtrate with glucoamylase, thereby obtaining a water-soluble polysaccharide extract. Ammonium sulfate is added to a culture filtrate prepared by culturing Lentinula edodes of basidiomycetes, thereby obtaining an enzyme complex from the precipitate. This enzyme complex is added to the water-soluble polysaccharide extract, and the mixture is caused to react at a pH of 4.5 for 30 to 60 min and further react at a pH of 6.0 for 30 to 60 min, thereby biologically modifying the water-soluble polysaccharide extract and obtaining the product.

Abstract: A blood-viscosity reducing agent contains a protein derived from Bacillus subtilis natto and including, sequentially from an amino group terminal, a first structural amino acid sequence having alanine, threonine, aspartic acid, glycine, valine, glutamic acid, tryptophan, asparagine, valine, aspartic acid, glutamine, isoleucine, aspartic acid, alanine, proline, lysine, alanine, tryptophan, alanine, leucine, glycine, tyrosine aspartic, acid, glycine, threonine, glycine, threonine, valine, valine, alanine, serine, isoleucine, aspartic acid, threonine, glycine, valine, glutamic acid, tryptophan, asparagine, histidine, proline, alanine, leucine, lysine, glutamic acid, lysine, tyrosine, arginine, glycine, tyrosine, asparagine, proline, glutamic acid, asparagine, proline, asparagine, glutamic acid, proline, glutamic acid, asparagine, glutamic acid, methionine, asparagine, tryptophan, tyrosine, aspartic acid, alanine, valine, alanine, glycine, glutamic acid, alanine, serine, proline, tyrosine, aspartic acid, aspartic

Abstract: A blood-viscosity reducing agent contains a protein derived from Bacillus subtilis natto and including, sequentially from an amino group terminal, a first structural amino acid sequence having alanine, threonine, aspartic acid, glycine, valine, glutamic acid, tryptophan, asparagine, valine, aspartic acid, glutamine, isoleucine, aspartic acid, alanine, proline, lysine, alanine, tryptophan, alanine, leucine, glycine, tyrosine aspartic, acid, glycine, threonine, glycine, threonine, valine, valine, alanine, serine, isoleucine, aspartic acid, threonine, glycine, valine, glutamic acid, tryptophan, asparagine, histidine, proline, alanine, leucine, lysine, glutamic acid, lysine, tyrosine, arginine, glycine, tyrosine, asparagine, proline, glutamic acid, asparagine, proline, asparagine, glutamic acid, proline, glutamic acid, asparagine, glutamic acid, methionine, asparagine, tryptophan, tyrosine, aspartic acid, alanine, valine, alanine, glycine, glutamic acid, alanine, serine, proline, tyrosine, aspartic acid, aspartic

Abstract: In a method of producing an immunopotentiator, a plant tissue material is extracted with hot water, the insoluble material is filtered, and the filtrate thereof is treated with glucoamylase to decompose a starch, thereby obtaining a water-soluble polysaccharide. Ammonium sulfate is added in a culture filtrate obtained by culturing any one of Asp Oryzae of the Aspergillaceae and Lentinus edodes of the Basidiomycetes to obtain an enzyme complex from the precipitate. The water-soluble polysaccharide and the enzyme complex are added together to cause them to react at a pH of 4.5 for 30 to 60 minutes and then at a pH of 6.0 for 30 to 60 minutes, thereby biologically modifying the water-soluble polysaccharide.