Abstract: A system for characterizing a region of interest of a biological tissue that includes a sighting device that produces an image in reflection of an elementary surface of the biological tissue. The system further includes a microscopic analysis device that detects, in a detection pattern included in the elementary surface, a light beam emitted by the biological tissue in response to illumination of the biological tissue and generates microscopic analysis information, and to determine a tissue characterization parameter from the microscopic analysis information. The system further includes a processing module that localizes, relative to a surface image of the region of interest, each elementary surface image of various elementary surface images and produces a map element for the characterization parameter. The system further includes a display module that displays a tissue map.

Abstract: A system for characterizing a region of interest of a biological tissue that includes a sighting device that produces an image in reflection of an elementary surface of the biological tissue. The system further includes a microscopic analysis device that detects, in a detection pattern included in the elementary surface, a light beam emitted by the biological tissue in response to illumination of the biological tissue and generates microscopic analysis information, and to determine a tissue characterization parameter from the microscopic analysis information. The system further includes a processing module that localizes, relative to a surface image of the region of interest, each elementary surface image of various elementary surface images and produces a map element for the characterization parameter. The system further includes a display module that displays a tissue map.

Abstract: The present description relates to a device that includes: a microscope lens with an optical axis; a mounting that includes a distal portion, in which the microscope lens is arranged; a first end piece fixed in a removable manner, in a first operating mode for in vivo microscopic analysis of the skin, to the distal portion of the mounting; a second end piece fixed in a removable manner, in a second operating mode for ex vivo microscopic analysis of a sample, to the distal portion of the mounting; a sample carrier with a receiving surface; a support that cooperates with the second end piece in the second operating mode so as to receive the mounting so that the optical axis of the microscope lens is substantially aligned in a predetermined direction with respect to the receiving surface.

Abstract: The present description relates to a device that includes: a microscope lens with an optical axis; a mounting that includes a distal portion, in which the microscope lens is arranged; a first end piece fixed in a removable manner, in a first operating mode for in vivo microscopic analysis of the skin, to the distal portion of the mounting; a second end piece fixed in a removable manner, in a second operating mode for ex vivo microscopic analysis of a sample, to the distal portion of the mounting; a sample carrier with a receiving surface; a support that cooperates with the second end piece in the second operating mode so as to receive the mounting so that the optical axis of the microscope lens is substantially aligned in a predetermined direction with respect to the receiving surface.

Abstract: The present description relates to a system for microscopic analysis of a sample that includes a microscopic analysis path and a sighting path. The microscopic analysis path notably includes an illumination path that illuminates the sample through a microscope objective of given nominal numerical aperture in a given field of view and a detection path including the microscope objective, and that detects in the field of view and according to a detection pattern, a light beam emitted by the sample in response to the illumination of the sample. The sighting path includes the microscope objective, a device for full field illumination of the sample, a two-dimensional detector, one or more imaging elements forming, with the microscope objective, a full field imaging device that forms a surface reflection sighting image of the sample of a given effective field encompassing the field of view.

Abstract: The present description relates to a system for microscopic analysis of a sample that includes a microscopic analysis path and a sighting path. The microscopic analysis path notably includes an illumination path that illuminates the sample through a microscope objective of given nominal numerical aperture in a given field of view and a detection path including the microscope objective, and that detects in the field of view and according to a detection pattern, a light beam emitted by the sample in response to the illumination of the sample. The sighting path includes the microscope objective, a device for full field illumination of the sample, a two-dimensional detector, one or more imaging elements forming, with the microscope objective, a full field imaging device that forms a surface reflection sighting image of the sample of a given effective field encompassing the field of view.

Abstract: The present description relates to a device for line-scanning optical coherence tomographic microscopy. The device comprises an interferometric microscope comprising a reference arm, an object arm configured to receive an object, a beam splitter coupling said object arm and reference arm to a light source and to a sensor, and a first microscope objective arranged on said object arm. It further comprises a one-dimensional confocal spatial filtering device configured to interact with said light source in order to illuminate said object along a focal line located in an object space of the first microscope objective, and a device for unidirectional scanning of said focal line, which device is arranged on said object arm upstream of said first microscope objective and is configured to scan the focal line in a lateral direction (y) substantially perpendicular to an optical axis (z) of said first microscope objective.

Abstract: The present description relates to a device for line-scanning optical coherence tomographic microscopy. The device comprises an interferometric microscope comprising a reference arm, an object arm configured to receive an object, a beam splitter coupling said object arm and reference arm to a light source and to a sensor, and a first microscope objective arranged on said object arm. It further comprises a one-dimensional confocal spatial filtering device configured to interact with said light source in order to illuminate said object along a focal line located in an object space of the first microscope objective, and a device for unidirectional scanning of said focal line, which device is arranged on said object arm upstream of said first microscope objective and is configured to scan the focal line in a lateral direction (y) substantially perpendicular to an optical axis (z) of said first microscope objective.

Abstract: A dynamic focusing system (DFS) for an optical device for observing an object. The dynamic focusing system (DFS) has an objective housing (OBH) including a circumferential housing part (CIH) and a light-transmitting window (LTW); a chamber (ICH) filled with an immersion medium having a refractive index substantially equal to the refractive index of the object to be observed; a movable immersed objective (MIO) configured to move along at least one direction so as to vary the focusing depth and being at least partially immersed in the immersion medium. The immersion medium is confined in the chamber (ICH) by a deformable sealing member (DSM) attached to the movable immersed objective (MIO) and to the objective housing (OBH). The deformable sealing member (DSM) is configured to ensure that the volume of the chamber (ICH) remains substantially constant upon displacement of the movable immersed objective (MIO) relative to the objective housing (OBH).

Abstract: A dynamic focusing system (DFS) for an optical device for observing an object. The dynamic focusing system (DFS) has an objective housing (OBH) including a circumferential housing part (CIH) and a light-transmitting window (LTW); a chamber (ICH) filled with an immersion medium having a refractive index substantially equal to the refractive index of the object to be observed; a movable immersed objective (MIO) configured to move along at least one direction so as to vary the focusing depth and being at least partially immersed in the immersion medium. The immersion medium is confined in the chamber (ICH) by a deformable sealing member (DSM) attached to the movable immersed objective (MIO) and to the objective housing (OBH). The deformable sealing member (DSM) is configured to ensure that the volume of the chamber (ICH) remains substantially constant upon displacement of the movable immersed objective (MIO) relative to the objective housing (OBH).