Patents Assigned to Dance Biopharm Inc.
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Patent number: 10569033Abstract: A dispenser for supplying a metered volume of a liquid medicament to an aerosolizing device. The dispenser may include a container having a proximal end and a distal end, wherein the container is configured to store a volume of liquid medicament. The dispenser may also include a dispensing mechanism coupled to the distal end of the container. The dispensing mechanism may have a distal end terminating in a tip through which the liquid medicament is dispensed. The dispensing mechanism operates to dispense a metered volume of the liquid medicament from the tip each time the dispensing mechanism is operated. The distal end of the dispensing mechanism includes an interface that interacts with a housing of an inhaler to limit an insertion depth of the tip into an opening the housing.Type: GrantFiled: April 16, 2014Date of Patent: February 25, 2020Assignee: Dance Biopharm Inc.Inventors: John S. Patton, Ryan S. Patton, Lisa Molloy, Jim Fink
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Patent number: 10525214Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.Type: GrantFiled: May 26, 2016Date of Patent: January 7, 2020Assignee: Dance Biopharm Inc.Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
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Patent number: 10471222Abstract: In one aspect, embodiments of the present invention provide an aerosolization device for ensuring proper delivery of an aerosolized medication to a user's respiratory system. The aerosolization device may include a conduit, an aerosol generator, a restrictor disposed within the conduit, and an indicator mechanism. The conduit may include a mouthpiece end by which a user may cause inspiratory flow through the conduit. The aerosol generator may include a vibratable mesh. The restrictor may define a plurality of apertures disposed along an outer periphery of the restrictor configured to provide an increase in pressure differential that varies with an inspiratory flow rate within the conduit and to provide a relatively laminar flow downstream of the restrictor compared to upstream of the restrictor. The indicator mechanism may indicate to a user a state of a parameter of the inspiratory flow relative to a predefined desired range.Type: GrantFiled: June 18, 2015Date of Patent: November 12, 2019Assignee: Dance Biopharm Inc.Inventors: Jim Fink, Lisa Molloy, Ronan MacLoughlin, Claire Lillis, Michael Casey, John Mullins, Kieran Hyland, Joe Grehan
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Patent number: 10307550Abstract: Liquid drug cartridges and an associated inhaler are used to deliver one more separate doses of an aerosolized liquid drug. A cartridge includes a container for storing the liquid drug, an end cap having an ejection opening, a filter element, and a piston that is repositionable relative to the container to selectively eject a volume of liquid drug from the ejection opening. The filter element filters the liquid drug prior to ejection from the ejection opening. The liquid drug cartridge can be coupled with an inhaler that includes an aerosol generator. The aerosol generator includes a vibratable membrane onto which the liquid drug is ejected. The liquid drug is aerosolized by the vibration of the membrane for inhalation by a user.Type: GrantFiled: June 5, 2015Date of Patent: June 4, 2019Assignee: Dance Biopharm Inc.Inventors: Benjamin Stedman, Jim Fink, Lisa Molloy, Matt Sander
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Publication number: 20190160153Abstract: Liquid formulations of insulin that contain physically and chemically stable insulin but do not contain preservatives or stabilizers are provided. The formulations also lack surfactants. The formulations are useful for various modes of delivery including pulmonary delivery.Type: ApplicationFiled: October 23, 2018Publication date: May 30, 2019Applicant: Dance BioPharm, Inc.Inventors: Blaine Bueche, Mei-Chang Kuo, John Patton, Matthew Sander
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Publication number: 20190054259Abstract: Liquid formulations of insulin that contain physically and chemically stable insulin but do not contain preservatives or stabilizers are provided. The formulations also lack surfactants. The formulations are useful for various modes of delivery including pulmonary delivery.Type: ApplicationFiled: October 23, 2018Publication date: February 21, 2019Applicant: Dance BioPharm, Inc.Inventors: Blaine Bueche, Mei-Chang Kuo, John Patton, Matthew Sander
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Patent number: 10076613Abstract: One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The formulation includes a major amount of water and a minor amount of insulin. Further, the formulation is preservative free, without meta-cresol, cresol or phenol, to permit the formulation to be aerosolized using a vibrating aperture plate without substantial foaming of the insulin formulation.Type: GrantFiled: October 8, 2015Date of Patent: September 18, 2018Assignee: Dance Biopharm Inc.Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
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Publication number: 20180021530Abstract: In one aspect, embodiments of the present invention provide an aerosolization device for ensuring proper delivery of an aerosolized medication to a user's respiratory system. The aerosolization device may include a conduit, an aerosol generator, a restrictor disposed within the conduit, and an indicator mechanism. The conduit may include a mouthpiece end by which a user may cause inspiratory flow through the conduit. The aerosol generator may include a vibratable mesh. The restrictor may define a plurality of apertures disposed along an outer periphery of the restrictor configured to provide an increase in pressure differential that varies with an inspiratory flow rate within the conduit and to provide a relatively laminar flow downstream of the restrictor compared to upstream of the restrictor. The indicator mechanism may indicate to a user a state of a parameter of the inspiratory flow relative to a predefined desired range.Type: ApplicationFiled: August 7, 2017Publication date: January 25, 2018Applicant: Dance Biopharm Inc.Inventors: Jim Fink, Lisa Molloy, Ronan McLaughlin, Claire Elizabeth Lillis, Michael Joseph Casey, John Matthew Mullins, Kieran James Hyland, Joseph Martin Grehan
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Patent number: 9545488Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.Type: GrantFiled: January 27, 2015Date of Patent: January 17, 2017Assignee: Dance Biopharm Inc.Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
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Publication number: 20160243199Abstract: Liquid formulations of insulin that contain physically and chemically stable insulin but do not contain preservatives or stabilizers are provided. The formulations also lack surfactants. The formulations are useful for various modes of delivery including pulmonary delivery.Type: ApplicationFiled: December 21, 2015Publication date: August 25, 2016Applicant: Dance BioPharm, Inc.Inventors: Blaine Bueche, Mei-Chang Kuo, John Patton, Matthew Sander
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Publication number: 20160158471Abstract: An insulin dispenser receives blood glucose readings wirelessly from a blood glucose monitor, and calculates an insulin dose based on the historical response of the particular patient to prior insulin doses. The insulin dispenser preferably nebulizes an insulin-containing fluid for inhalation by the patient.Type: ApplicationFiled: December 3, 2015Publication date: June 9, 2016Applicant: Dance Biopharm, Inc.Inventors: Jim Fink, Michael Shawver, Lisa Molloy, Ben Stedman
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Publication number: 20160129088Abstract: One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The formulation comprises a major amount of water and a minor amount of insulin. Further, the formulation is preservative free, without meta-cresol, cresol or phenol, to permit the formulation to be aerosolized using a vibrating aperture plate without substantial foaming of the insulin formulation.Type: ApplicationFiled: October 8, 2015Publication date: May 12, 2016Applicant: Dance Biopharm Inc.Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
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Patent number: 9180261Abstract: One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The formulation includes a major amount of water and a minor amount of insulin. Further, the formulation is preservative free, without meta-cresol, cresol or phenol, to permit the formulation to be aerosolized using a vibrating aperture plate without substantial foaming of the insulin formulation.Type: GrantFiled: January 11, 2011Date of Patent: November 10, 2015Assignee: Dance Biopharm Inc.Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
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Patent number: 9004061Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.Type: GrantFiled: September 27, 2013Date of Patent: April 14, 2015Assignee: Dance Biopharm, Inc.Inventors: John S. Patton, Ryan S. Patton, Mei-chang Kuo, Yehuda Ivri
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Patent number: 8950394Abstract: An aerosolization system includes a squeezable container having a resilient container body. The container is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.Type: GrantFiled: January 11, 2011Date of Patent: February 10, 2015Assignee: Dance Biopharm Inc.Inventors: John S. Patton, Ryan S. Patton, Mei-Chang Kuo, Yehuda Ivri