Abstract: A mass spectrometer with a wide dynamic range, having:—a source (2) of ion beams,—an analyzer (4) for the ion beams generated by said source (2),—a detector (6) for the ions separated by said analyzer (4),—a treatment stage (8) for the analogue signal A generated by said detector, to obtain two separate signals A1=mA and A2=nA, where m>n, characterised by comprising:—an analogue/digital converter (10) for converting both said analogue signals A1 and A2 into two numerical values D1 and D2,—a controller (12) which receives both the numerical values D1 and D2 as input, and provides as output a single value equal to D1 if D1 is less than the end-of-scale value of the converter (10), or a value equal to (m/n)D2 if D1 is equal to the end-of-scale value of the converter.

Abstract: A device for generating micro- and nanoflow mobile phase gradients for high performance liquid chromatography includes a generator of micro- and nanoflows of at least two mobile phases in different percentage compositions; an n-position gradient distributor having inlet and outlet ports and n couples of ports for a like number of capillary loops, each selectively connectable at one end with the inlet port and at its other end to the outlet port, which in turn is connectable to an analytical circuit that includes a chromatographic column and a detector; a micro- and nanoflow meter connected to the analytical circuit; a flow deviator having an inlet connected to the outlet of the gradient distributor, one outlet connected to a discharge and another outlet connected to the micro- and nanoflow meter, and a control unit that includes means of control of the generator of micro- and nanoflows such to create the different mobile phase mixture compositions, means for controlling the gradient distributor, means for con

Abstract: A device for generating micro- and nanoflow mobile phase gradients for high performance liquid chromatography includes a generator of micro- and nanoflows of at least two mobile phases in different percentage compositions; an n-position gradient distributor having inlet and outlet ports and n couples of ports for a like number of capillary loops, each selectively connectable at one end with the inlet port and at its other end to the outlet port, which in turn is connectable to an analytical circuit that includes a chromatographic column and a detector; a micro- and nanoflow meter connected to the analytical circuit; a flow deviator having an inlet connected to the outlet of the gradient distributor, one outlet connected to a discharge and another outlet connected to the micro- and nanoflow meter, and a control unit that includes means of control of the generator of micro- and nanoflows such to create the different mobile phase mixture compositions, means for controlling the gradient distributor, means for con

Abstract: A method for directly injecting a liquid sample into a capillary chromatography column, by which a liquid sample that includes the substance to be analyzed and the relative solvent is withdrawn from a vial with an automatic sampler having a syringe with a needle, and is then introduced into an insert, with which the injector of the chromatograph is provided, such that the terminal portion of the chromatography column is coaxially inserted into the needle to cause migration by capillarity of a part of the sample from the needle to the column. Excess sample overflowing from the needle at the moment in which the end of said column is inserted thereinto is received in a cavity, and the residence time of the end of the column within the needle is controlled.

Abstract: A flow regulator device for an analytical circuit, characterised by comprising: a fluid restriction (R) of defined characteristics related to the field of application of the analytical circuit, a direct-pressure regulator (2) positioned upstream of said restriction (R), a back pressure regulator (4) positioned downstream of said restriction (R).