Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
Type:
Grant
Filed:
March 26, 2004
Date of Patent:
December 2, 2008
Assignee:
Danisco A/S, Genencor Division
Inventors:
Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
Abstract: Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
Type:
Grant
Filed:
March 19, 2004
Date of Patent:
November 18, 2008
Assignee:
Danisco A/S, Genencor Division
Inventors:
Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe
Abstract: The present invention provides a novel cellulase nucleic acid sequence, designated mHKcel, and the corresponding mHKcel amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding mHKcel, recombinant mHKcel proteins and methods for producing the same.
Type:
Grant
Filed:
April 28, 2004
Date of Patent:
November 11, 2008
Assignee:
Danisco A/S, Genencor Division
Inventors:
Brian E. Jones, William D. Grant, Shaun Heaphy, Susan Grant, Helen Rees
Abstract: The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.
Type:
Grant
Filed:
May 10, 2004
Date of Patent:
September 2, 2008
Assignee:
Danisco A/S, Genencor Division
Inventors:
Timothy C. Dodge, Manoj Kumar, M. Harunur Rashid, Fernando Valle
Abstract: The present invention provides a novel ?-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL7, recombinant BGL7 proteins and methods for producing the same.
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