Abstract: An instrument for vaginal inspection or exploration consists of separate speculum and depressor components, each molded from plastic material. The handles of the components are adapted to be releasably interfitted in a dovetail manner to form a unitary handle, with the handles being longitudinally slidable relative to each other to adjust the separation between the speculum and depressor blades. The dovetail arrangement includes toothed locking flanges on the depressor handle which releasably cooperate with teeth on the sides of the speculum handle. By depressing a transverse web portion or button, the flanges are flexed apart to allow longitudinal adjustment between the handles, using one hand only. The depressor handle includes an intermediate member connected to the depressor blade. This intermediate member is of an arcuate, laterally offset configuration so as to provide unobstructed access to the space between the blades in the longitudinal direction of the blades.